Quality control method of traditional Chinese medicine composition with phlegm eliminating and cough relieving effects

A technology for eliminating phlegm and relieving cough and composition, which is applied in the field of traditional Chinese medicine, and can solve the problems of undiscovered reports on the quality control methods of traditional Chinese medicine compositions, and achieve the effects of being beneficial to product quality control, quick onset of action, and convenient transportation and carrying

Inactive Publication Date: 2020-08-07
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dropping pill of the present invention has not been reported before the completion of the present invention, and before the completion of the p

Method used

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  • Quality control method of traditional Chinese medicine composition with phlegm eliminating and cough relieving effects
  • Quality control method of traditional Chinese medicine composition with phlegm eliminating and cough relieving effects
  • Quality control method of traditional Chinese medicine composition with phlegm eliminating and cough relieving effects

Examples

Experimental program
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Effect test

example 1

[0063] The preparation method of example one composition of the present invention

[0064]

[0065] For the above six flavors, take purple rhododendron, kansui, and genkwa, use 8 times the amount of 65% ethanol to reflux extract twice, each time for 2 hours, filter, combine the filtrate, recover ethanol, concentrate to a relative density of 1.30~ when measured at 60 ° C 1.35 thick paste, dried and crushed to obtain ethanol extract, set aside; take Codonopsis pilosula, Pinellia chinensis, and alum, decoct twice with 8 times the amount of water for 2 hours each time, filter, combine filtrates, and concentrate to 60°C When measuring the thick paste with a relative density of 1.30-1.35, dry, pulverize, and obtain a water extract for later use; add the fine powder of the above-mentioned extract into a hot-melted 2-fold amount of polyethylene glycol 6000 matrix, stir and mix evenly, and transfer Put it on the dripping pill device, keep it sealed at 80-90°C, drop it into the cond...

example 2

[0066] The thin layer identification method of example two compositions of the present invention

[0067] a. Take 6g of this product, grind it finely, add 40ml of ethanol, heat and reflux for 1 hour, filter, evaporate the filtrate to dryness, add 25ml of water to the residue to dissolve, shake and extract 3 times with ethyl acetate, 25ml each time, combine ethyl acetate solution, add water to wash 2 times, 25ml each time, discard the water solution, evaporate the ethyl acetate solution to dryness, add 1ml of methanol to the residue to dissolve, and use it as the test solution; take 1g of Daphne genkwa as a reference drug, and prepare the reference drug solution in the same way ; Take 4 μl of each of the above two solutions, spot them on the same silica gel G thin-layer plate, use chloroform-ethyl acetate-formic acid = 20:5:1 as the developer, develop, take out, dry in the air, and spray with 5 % aluminum chloride ethanol solution, blown with hot air until the spots are clear...

example 3

[0071] The assay method of example three compositions of the present invention

[0072] Quercetin was determined according to high-performance liquid chromatography (Chinese Pharmacopoeia 2015 Edition Sibu General Rules 0512).

[0073] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; methanol-0.4% phosphoric acid solution = 49:51 is used as mobile phase; detection wavelength is 370nm; the number of theoretical plates should be calculated according to the peak of quercetin No less than 4000.

[0074] Preparation of reference substance solution Take an appropriate amount of quercetin reference substance, weigh it accurately, add methanol to make a solution containing 15 μg per 1 ml, and obtain it.

[0075]Preparation of the test solution Take this product, grind it finely, take about 1.0g, accurately weigh it, put it in a stoppered Erlenmeyer flask, add 25ml of 80% methanol precisely, seal it tightly, weigh it, heat ...

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Abstract

The invention relates to a preparation method and a quality control method of a traditional Chinese medicine composition with phlegm eliminating and cough relieving effects. According to the formula,the composition consists of six raw materials of codonopsis pilosula, rhizoma typhonii flagelliformis, flos genkwa, euphorbia kansui, rhododendron mariae and alumen; according to the invention, different routes are adopted for extraction to prepare dripping pills, wherein through reasonable compatibility and optimal preparation, the effects of the dripping pills supplement each other, the effectsof tonifying the spleen, drying dampness, eliminating phlegm and stopping coughing are achieved, and the dripping pills are mainly used for chronic bronchitis and symptoms such as excessive phlegm, coughing and asthma caused by bronchitis combined with emphysema and pulmonary heart disease. The preparation process disclosed by the invention overcomes the defects of the traditional Chinese medicineprocess, and the prepared dropping pill is stable in quality, easy to store, quick to take effect, enhanced in curative effect, small in dosage and convenient to transport and carry.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a preparation method of a traditional Chinese medicine composition with functions of eliminating phlegm and relieving cough and a quality control method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Bronchitis can be divided into acute and chronic, and it is the most common respiratory disease in clinical practice. According to its clinical manifestations, traditional Chinese medicine usually attributes it to the categories of "cough", "phlegm retention" and "dyspnea syndrome". Among them, chronic bronchitis is often caused by damage to the spleen and lungs due to repeated cold and cold drinks, which last for a long time. "Life Method Secrets" says: "Cough means there is no phlegm but there is sound, and the lung qi is injured and unclear. Cough due to lung qi, which is caused by spleen...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/20A61P11/10A61P11/14A61P11/00A61P9/00A61P11/06G01N30/95G01N30/94G01N30/91G01N30/02G01N30/06G01N30/34G01N30/74G01N30/36A61K33/06
CPCA61K9/2031A61K33/06A61K36/344A61K36/45A61K36/47A61K36/83A61K36/8888A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P9/00A61P11/00A61P11/06A61P11/10A61P11/14G01N30/02G01N30/06G01N30/34G01N30/36G01N30/74G01N30/91G01N30/94G01N30/95A61K2300/00
Inventor 赫玉芳丁云录谢晓燕
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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