The invention relates to a specific medicament for treating empyrosis and a preparation method thereof. The medicament comprises the following components in part by mass: 1 to 3 parts of shortleaf kyllinga herb, 1 to 3 parts of Chinese ilex leaf, 1 to 3 parts of herba pteridis multifidae, 1 to 3 parts of coriaria sinica maxim, 1 to 3 parts of hairy nanocnide, 1 to 3 parts of golden thread, 1 to 3 parts of cortex phellodendri, 1 to 3 parts of baical skullcap root, 1 to 3 parts of garden burnet root, 1 to 3 parts of rhubarb, 1 to 3 parts of gypsum rubrum, 1 to 3 parts of frankincense, 1 to 3 parts of common selfheal fruit-spike and 1 to 3 parts of borneol, and the medicament also comprises sesame oil. The preparation method of the medicament comprises the following steps of: A, selecting 1 part of the high-quality shortleaf kyllinga herb, 1 part of the Chinese ilex leaf, 1 part of the herba pteridis multifidae, 1 part of the coriaria sinica maxim, 1 part of the hairy nanocnide, 1 part of the golden thread, 1 part of the cortex phellodendri, 1 part of the baical skullcap root, 1 part of the garden burnet root, 1 part of the rhubarb, 1 part of the gypsum rubrum, 1 part of the frankincense, 1 part of the common selfheal fruit-spike and 1 part of the borneol, and grinding the components into powder respectively; and B, putting the ground powder into a container, and stirring uniformly for sealing. A using method of the medicament comprises that the pasty finished medicament is applied to lesion sites for 1 to 2 hours each time, and the lesion sites are cleaned after 168 to 720 hours. The medicament, by using common Chinese medicinal herbs as raw materials, has the characteristics of quick analgesia, strong infection resistance, capability of inhibiting the exosmosis of body fluid effectively, no malformed sarcoma and cicatrices after curing, short treatment period, no toxic or side effect, low cost and the like, and can treat the empyrosis diseases completely.