The invention discloses a multi-nutrient health-care functional sesame cake and a preparing method thereof. The sesame cake comprises a wrapper, stuffing and crispy flour, wherein the wrapper comprises, by weight, 20-30 parts of flour, 2-3 parts of refined sesame oil, 5-10 parts of peanut oil, 2-3 parts of maltose, 1.5-2 parts of selenium enrichment pollen pini, 1-2 parts of hawthorn seed powder, 1-2 parts of trichosanthes kirilowii Maxim powder and an appropriate amount of water, the crispy flour comprises, by weight, 10-15 parts of flour, 2-3 parts of aloe powder, 2-3 parts of barley leaf powder, 1.5-2.5 parts of grape seed powder and 5-10 parts of peanut oil, and the stuffing comprises, by weight, 20-30 parts of fermented flour, 10-15 parts of sesame oil, 5-10 parts of bee milk, 4-8 parts of sesame crumb, 3-5 parts of pinenut kernel, 1-2 parts of hazelnut kernel, 1-2 parts of semen boitae, 2-3 parts of betavulgarisvar.cicla, 1-3 parts of purslane, 1-2 parts of gynura bicolor and 2-3 parts of boxthorn leaf. The sesame cake has the effects of clearing away heat and toxic materials, digesting, tonifying the spleen, moistening the lung, regulating the vital energy, facilitating diuresis, relaxing the bowel, preventing phlegm from forming and stopping coughing and the like. The toxin expelling, senescence deferring, blood circulation promoting, blood fat and blood glucose reducing, immunity boosting, tumor and cancer preventing and other functions can be achieved by often eating the sesame cake, and the sesame cake is suitable for being eaten by various crowds.