The invention discloses a medicine combination treating nasal furuncle. The medicine combination comprises the traditional Chinese medicine components including ampelopsis humulifolia bunge, loess, lespedeza formosa, chondrilla juncea, tarenna mollissima, a disinfectant, hainan ervatamia roots, jujube leaves, auricularia auricular, hedyotis uncinella, ludisia discolor, japalura polygonata, leycesteria taiwanensis, momordica roots, sophora alopecuroide, roegneria kamoji, straw, arrowhead leaves and achnatherum inebrians. The medicine combination further includes the following western medicine components comprising hyaluronidase, melittin, eupatilin, aromatic essential oil, L-arginine, phosphatidylcholine, sericin protein, hericium erinaceus polysaccharide, 0.02-0.025 part of release control agents and 0.015-0.05 part of water-soluble hydrophilic polymers. According to the medicine combination, various kinds of Chinese herbal medicine and western medicine components are selected, all the components are good in matching, and the medicine combination has no toxic and side effect, has no adverse effect of hormone, can dissipate heat and relieve pain and remove toxicity to for detumescence, has antisepsis and anti-inflammation functions, and can nourish yin and moisturize the lungs, promote blood circulation and remove dampness and enhance immunity of human bodies. As proved clinically, the medicine combination has a good treatment effect and is quick in effect and convenient to use.