8 results about "Breast Hyperplasia" patented technology

This invention relates to the application of ALKBH5 as a target in the preparation of drugs for inhibiting the progression of TNBC, and to the drugs themselves. This application discovers mRNA m 6 The alpha-modifying demethylase ALKBH5 is specifically highly expressed in triple-negative breast cancer (TNC). Using spontaneous TNC models and xenograft tumor models, knockout or knockdown of ALKBH5 significantly inhibited breast hyperplasia and the development of TNC, and promoted tumor differentiation. Simultaneously, the specific inhibitor EN300-14040 of ALKBH5 significantly inhibited the growth of TNC organoids, promoted TNC cell differentiation, and enhanced the sensitivity of TNC organoids to the endocrine drug 4OH-T, exhibiting a synergistic inhibitory effect with 4OH-T. Therefore, ALKBH5 represents a potential novel therapeutic target for TNC, and ALKBH5 inhibitors are a potential new type of drug for the treatment of TNC.

This invention relates to a novel use of propargylcysteine ​​in the preparation of anti-mastopathy drugs. The invention discovers that S-propargylcysteine ​​can improve E2 / P imbalance by regulating HPO axis function and inhibiting abnormal activation of the GnRH-sex hormone axis; it also reduces the inflammatory microenvironment by inhibiting the release of inflammatory factors; ultimately, it downregulates ER / PR-mediated proliferation signals and inhibits PCNA expression locally in the breast. Through multi-target regulation of neuroendocrine, inflammatory responses, and proliferation-related signaling pathways, it effectively alleviates breast hyperplasia and its associated chronic stress-induced depressive-like behaviors, thus exerting anti-mastopathy and therapeutic effects on breast hyperplasia complicated with depression.

The invention discloses a liquid medicine for conditioning breast diseases. The liquid medicine comprises the following raw materials by weight: 12-22 g of garden burnet; 15 to 25 g of prunella vulgaris; 17 to 27g of seaweed; and 14-24g of fructus liquidambaris. The raw materials of the medicine liquid for conditioning breast diseases are medicinal and edible or traditional Chinese medicinal materials, so that the medicine liquid is small in side effect and suitable for long-term conditioning; the traditional Chinese medicine composition has a direct treatment effect on hyperplasia of mammary glands and breast distending pain before menstruation, and can be used as a mild auxiliary conditioning means for more serious mammary gland diseases.

1. Name of the product in this design: Packaging Box (Far Infrared Therapy Patch - Breast Hyperplasia). 2. Purpose of this design: outer packaging box for the product. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses an external black plaster for treating soft tissue pain and osteoarticular diseases as well as a preparation method and application of the external black plaster. The black plaster is prepared from fineleaf schizonepeta herb, divaricate saposhnikovia root, garden balsam stem, dahurian angelica root, safflower, medicinal cyathula root, red peony root, Chinese angelica, dried orange peel, frankincense, myrrh, common duckweed herb, dried river shrimp, minium and sesame oil according to a specific ratio. The preparation method comprises the steps of material frying, oil refining, pellet feeding, fire toxin removing, spreading and the like. Based on the theory of treating different diseases at the same time in traditional Chinese medicine, aiming at the core pathogenesis of qi stagnation, blood stasis and meridian obstruction, the traditional Chinese medicine composition is scientific in formula and has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, dispelling wind and eliminating dampness and clearing and activating the channels and collaterals. Clinical application proves that the plaster has remarkable curative effects on soft tissue pain such as mastitis and hyperplasia of mammary glands and osteoarticular diseases such as lumbar disc herniation, arthritis and cervical spondylosis, is safe and convenient to use and has important clinical application value.

A pharmaceutical formulation for treating breast hyperplasia and a preparation method therefor. The pharmaceutical formulation comprises a drug-loaded microneedle layer, a backing layer connected to the drug-loaded microneedle layer, and a medical blank adhesive patch adhered to the backing layer. The drug-loaded microneedle layer is prepared from the following raw materials: a traditional Chinese medicine compound clear paste, a microneedle matrix and purified water. The traditional Chinese medicine compound clear paste is prepared from the following raw materials: radix bupleuri chinensis, curcumae radix, rhizoma cyperi, radix paeoniae alba, frankincense, rhizoma pinelliae, bulbus fritillariae thunbergii, spica prunellae, camphor essential oil, turpentine and a 70% ethanol solution. The backing layer is prepared from the following raw materials: a backing layer matrix and purified water.

The invention discloses a traditional Chinese medicine composition for treating female hyperplasia of mammary glands. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 50-70 parts of radix curcumae, 20-40 parts of pericarpium citri reticulatae viride, 20-40 parts of pericarpium citri reticulatae viride, 100-140 parts of fructus trichosanthis, 20-40 parts of ginger worms, 50-70 parts of radix paeoniae rubra, 50-70 parts of radix paeoniae alba and 50-70 parts of radix angelicae sinensis. All the raw materials are reasonable in compatibility and can effectively relieve inflammatory reaction and pain caused by hyperplasia of mammary glands through the synergistic effect, and meanwhile adjustment and recovery of a body immune system can be promoted. The traditional Chinese medicine preparation is a pure traditional Chinese medicine preparation and has little harm to the body and few side effects.

The invention relates to a traditional Chinese medicine ointment with the effects of warming and dredging, relieving pain, reducing swelling and removing stasis and a preparation method of the traditional Chinese medicine ointment, and the traditional Chinese medicine ointment is used for treating cold nodules and pain diseases of rheumatoid arthritis, hyperplasia of mammary glands and knee osteoarthritis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine compound has the effects of warming and removing dampness, promoting blood circulation to remove blood stasis, activating meridians to stop pain, softening hardness to dissipate stagnation and the like, and clinical research shows that the traditional Chinese medicine compound has a remarkable curative effect in the aspect of treating rheumatoid arthritis, hyperplasia of mammary glands and knee osteoarthritis and is good in safety. The invention also provides the medical application of the traditional Chinese medicine composition in treating the diseases, and a new technical scheme is provided for modernization of traditional Chinese medicines and development of compound preparations.