13 results about "Breast Hyperplasia" patented technology

This invention relates to the application of ALKBH5 as a target in the preparation of drugs for inhibiting the progression of TNBC, and to the drugs themselves. This application discovers mRNA m 6 The alpha-modifying demethylase ALKBH5 is specifically highly expressed in triple-negative breast cancer (TNC). Using spontaneous TNC models and xenograft tumor models, knockout or knockdown of ALKBH5 significantly inhibited breast hyperplasia and the development of TNC, and promoted tumor differentiation. Simultaneously, the specific inhibitor EN300-14040 of ALKBH5 significantly inhibited the growth of TNC organoids, promoted TNC cell differentiation, and enhanced the sensitivity of TNC organoids to the endocrine drug 4OH-T, exhibiting a synergistic inhibitory effect with 4OH-T. Therefore, ALKBH5 represents a potential novel therapeutic target for TNC, and ALKBH5 inhibitors are a potential new type of drug for the treatment of TNC.

The invention discloses a traditional Chinese medicine formula for treating hyperplasia of mammary glands and breast cancer and a preparation method thereof. The formula comprises radix paeoniae rubra, pseudo-ginseng, radix aucklandiae, swim bladder, angelica sinensis, blister beetle, rhizoma atractylodis macrocephalae and scorpion which are compatible according to a specific proportion. The preparation method comprises the following steps: adding water to soak the five medicinal materials such as red paeony root (1 hour in summer and 2 hours in winter), adding the swim bladder, decocting until the liquid medicine is sticky, grinding the baked cantharides and scorpion into powder, and mixing. Based on theories such as the holism concept of traditional Chinese medicine, multiple modules take effect synergistically, microcirculation can be improved, immunity can be enhanced, cancer cell apoptosis can be induced, the total effective rate for hyperplasia of mammary glands is 96.7%, and the total effective rate for I-II stage breast cancer reaches 86.7%. The traditional Chinese medicine is flexible to take, high in safety and suitable for long-term treatment.

This invention relates to a novel use of propargylcysteine ​​in the preparation of anti-mastopathy drugs. The invention discovers that S-propargylcysteine ​​can improve E2 / P imbalance by regulating HPO axis function and inhibiting abnormal activation of the GnRH-sex hormone axis; it also reduces the inflammatory microenvironment by inhibiting the release of inflammatory factors; ultimately, it downregulates ER / PR-mediated proliferation signals and inhibits PCNA expression locally in the breast. Through multi-target regulation of neuroendocrine, inflammatory responses, and proliferation-related signaling pathways, it effectively alleviates breast hyperplasia and its associated chronic stress-induced depressive-like behaviors, thus exerting anti-mastopathy and therapeutic effects on breast hyperplasia complicated with depression.

Hippophae rhamnoides seed oil and simmondsia chinensis seed oil are used as substrates, traditional Chinese medicine ingredients such as fructus forsythiae and radix salviae miltiorrhizae are compounded, and an ultramicro homogenization process is performed. The essence oil is suitable for people with hyperplasia of mammary glands and nodules, has the effects of promoting blood circulation to remove meridian obstruction and relieving swelling and pain, has the permeability of 98% within 15 minutes, and is non-irritant.

The invention discloses nucleus eliminating granules which are prepared by the following steps: adding water into 12 medicinal materials, namely selfheal, oyster, kelp, beautiful sweetgum fruit, fructus aurantii, cowherb seed, salvia miltiorrhiza, curcuma zedoary, ligusticum wallichii, white paeony root, corydalis tuber and radix bupleuri, heating, extracting, filtering, concentrating and drying to obtain medicinal powder; and sieving, adding auxiliary materials, adding a wetting agent, preparing a soft material, granulating, and drying to obtain the kernel eliminating granules. The invention further discloses a preparation method of the nucleus eliminating particles, a thin-layer chromatography identification and content determination method and application of the nucleus eliminating particles. According to the invention, the nucleus-eliminating mixture is developed into the nucleus-eliminating particles, the forming rate, the dissolution rate, the moisture absorption rate, the fluidity and the like of the nucleus-eliminating particles all meet the requirements of Chinese Pharmacopoeia, and the stability experiment result shows that the product stability is good; the curative effect of the nucleus eliminating granules on breast pain, breast nodules, hyperplasia of mammary glands and breast diseases can be achieved; doctors realize accurate medication under treatment based on syndrome differentiation, and the flexibility of adjusting prescriptions along with symptoms is guaranteed; on the other hand, more convenient carrying and taking experience can be provided for the patient.

The present invention provides an extraction method and application of Atractylodes macrocephala polysaccharide, which belongs to the technical field of traditional Chinese medicine. The present invention uses Atractylodes macrocephala as raw material, adopts ultrasonic synergistic subcritical water extraction and graded alcohol precipitation to extract Atractylodes macrocephala polysaccharide AMP-50, and purifies and separates AMP-50-I to III through DEAE-650M cellulose ion exchange resin. The extraction method of the present invention is not only easy to operate, time-saving and efficient, but also can improve the extraction rate and purity of Atractylodes macrocephala polysaccharide. Among them, the AMP-50 extraction rate can reach 12.13%, the sugar content is 84.31%, and the relative molecular weight is 7768 to 24628Da. And the Atractylodes macrocephala polysaccharide extracted by the present invention has the effect of effectively improving breast damage and breast hyperplasia.

The invention discloses a liquid medicine for conditioning breast diseases. The liquid medicine comprises the following raw materials by weight: 12-22 g of garden burnet; 15 to 25 g of prunella vulgaris; 17 to 27g of seaweed; and 14-24g of fructus liquidambaris. The raw materials of the medicine liquid for conditioning breast diseases are medicinal and edible or traditional Chinese medicinal materials, so that the medicine liquid is small in side effect and suitable for long-term conditioning; the traditional Chinese medicine composition has a direct treatment effect on hyperplasia of mammary glands and breast distending pain before menstruation, and can be used as a mild auxiliary conditioning means for more serious mammary gland diseases.

1. Name of the product in this design: Packaging Box (Far Infrared Therapy Patch - Breast Hyperplasia). 2. Purpose of this design: outer packaging box for the product. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses an external black plaster for treating soft tissue pain and osteoarticular diseases as well as a preparation method and application of the external black plaster. The black plaster is prepared from fineleaf schizonepeta herb, divaricate saposhnikovia root, garden balsam stem, dahurian angelica root, safflower, medicinal cyathula root, red peony root, Chinese angelica, dried orange peel, frankincense, myrrh, common duckweed herb, dried river shrimp, minium and sesame oil according to a specific ratio. The preparation method comprises the steps of material frying, oil refining, pellet feeding, fire toxin removing, spreading and the like. Based on the theory of treating different diseases at the same time in traditional Chinese medicine, aiming at the core pathogenesis of qi stagnation, blood stasis and meridian obstruction, the traditional Chinese medicine composition is scientific in formula and has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, dispelling wind and eliminating dampness and clearing and activating the channels and collaterals. Clinical application proves that the plaster has remarkable curative effects on soft tissue pain such as mastitis and hyperplasia of mammary glands and osteoarticular diseases such as lumbar disc herniation, arthritis and cervical spondylosis, is safe and convenient to use and has important clinical application value.

A pharmaceutical formulation for treating breast hyperplasia and a preparation method therefor. The pharmaceutical formulation comprises a drug-loaded microneedle layer, a backing layer connected to the drug-loaded microneedle layer, and a medical blank adhesive patch adhered to the backing layer. The drug-loaded microneedle layer is prepared from the following raw materials: a traditional Chinese medicine compound clear paste, a microneedle matrix and purified water. The traditional Chinese medicine compound clear paste is prepared from the following raw materials: radix bupleuri chinensis, curcumae radix, rhizoma cyperi, radix paeoniae alba, frankincense, rhizoma pinelliae, bulbus fritillariae thunbergii, spica prunellae, camphor essential oil, turpentine and a 70% ethanol solution. The backing layer is prepared from the following raw materials: a backing layer matrix and purified water.

The utility model provides a massage nursing device for hyperplasia of mammary glands. The massage nursing device comprises a handle, a massage mechanism, a driving mechanism, two oppositely-arranged connecting rods and an adjusting mechanism. Wherein the interior of the handle is of a hollow structure; the massage mechanism is arranged at the top of the handle; the driving mechanism is arranged in the massage mechanism and is used for driving the massage mechanism to vibrate and rotate; one ends of the two oppositely-arranged connecting rods are arranged at the top of the handle in a sliding mode, and the other ends of the two oppositely-arranged connecting rods are rotationally connected with the massage mechanism; the adjusting mechanism is arranged on the handle and used for adjusting the distance between the two oppositely-arranged connecting rods, and therefore the distance between the massage mechanisms is adjusted. By arranging the adjusting mechanism, the distance between the massage mechanisms can be adjusted according to the requirements of the user, so that the massage comfort of the user during use is improved.

The invention discloses a traditional Chinese medicine composition for treating female hyperplasia of mammary glands. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 50-70 parts of radix curcumae, 20-40 parts of pericarpium citri reticulatae viride, 20-40 parts of pericarpium citri reticulatae viride, 100-140 parts of fructus trichosanthis, 20-40 parts of ginger worms, 50-70 parts of radix paeoniae rubra, 50-70 parts of radix paeoniae alba and 50-70 parts of radix angelicae sinensis. All the raw materials are reasonable in compatibility and can effectively relieve inflammatory reaction and pain caused by hyperplasia of mammary glands through the synergistic effect, and meanwhile adjustment and recovery of a body immune system can be promoted. The traditional Chinese medicine preparation is a pure traditional Chinese medicine preparation and has little harm to the body and few side effects.

The invention relates to a traditional Chinese medicine ointment with the effects of warming and dredging, relieving pain, reducing swelling and removing stasis and a preparation method of the traditional Chinese medicine ointment, and the traditional Chinese medicine ointment is used for treating cold nodules and pain diseases of rheumatoid arthritis, hyperplasia of mammary glands and knee osteoarthritis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine compound has the effects of warming and removing dampness, promoting blood circulation to remove blood stasis, activating meridians to stop pain, softening hardness to dissipate stagnation and the like, and clinical research shows that the traditional Chinese medicine compound has a remarkable curative effect in the aspect of treating rheumatoid arthritis, hyperplasia of mammary glands and knee osteoarthritis and is good in safety. The invention also provides the medical application of the traditional Chinese medicine composition in treating the diseases, and a new technical scheme is provided for modernization of traditional Chinese medicines and development of compound preparations.