The invention provides a preparation for effectively treating a fatty liver. The preparation is prepared from the following traditional Chinese medicine materials: artemisia capillaries, pollen typhae, tea tree root, cynanchum wilfordii, rhizoma corydalis, pinellia ternate, fructus akebiae, pueraria flower, bamboo shavings, seaweed, indigo naturalis, rice bean flower, trogopterus dung, verbena, green gram flower, setose thistle, zedoary, kelp, amomum cardamomum, garden burnet, pericarpium citri reticulatae viride, fructus liquidambaris, persimmon frost, lemon, mother chrysanthemum, ruddle, sophora flower and fiveleaf akebia fruit. The preparation for effectively treating the fatty liver, which is free of toxic and side effects, safe to medicate, and significant in treatment effect, and can be taken for a long period of time is provided by the invention. The preparation has the treatment principles of activating blood and removing blood stasis, tonifying the spleen and nourishing the liver, clearing damp, nourishing yin and promoting the secretion of saliva, can be used for treating both symptoms and root causes, and achieves the effects of being smooth in blood operation, sufficient in body fluid, invigorating the spleen and the liver, and sufficient in blood supply of a brain, a series of clinical symptoms caused by the fatty liver are treated, lesion of the fatty liver is retarded, and the quality of working and life of people is improved.