The invention discloses Chinese medicinal compound potentilla chinensis powder or a particle preparation for conditioning and treating an emaciation-thirst disease. A formula consists of 39 Chinese medicinal materials including potentilla chinensis, Chinese wolfberry root-bark, mulberry leaf, American ginseng, cynomorium coccineum, prepared rehmannia rhizome, rehmannia root, dwarf lilyturf root, sweet potato, tartary buckwheat, fiveleaf gynostemma herb, ginkgo, bitter orange, dark plum fruit, fructus corni, whole worm, liquoric root, tree peony root-bark, Chinese angelica root, figwort, fragrant solomonseal rhizome, sealwort, kudzuvine root, astragalus, Chinese yam, bombys batryticatus, Chinese atractylodes, hiraute shiny bugleweed herb, red-rooted salvia root, pearl powder, bamboo shavings, mulberry fruit, buerger pipewort flower, tribulus terrestris, rehmannia root, Mongolian snakegourd root, safflower, calculus bovis (or artificial calculus bovis), notoginseng root, and a packing material. The Chinese medicinal compound potentilla chinensis powder or particle preparation has the advantages and effects of plenty Chinese medicinal resources, easiness for preparing and processing a medicament, convenience for taking, strong targeting force, good curative effect, no toxic or side effect, application to prevention, conditioning and treatment of diseases such as the emaciation-thirst disease, or early light complicating diseases, high blood sugar content, high urea sugar content and the like caused by type II diabetes by internal taking, high clinical symptomatic treatment total effective rate, and the like.