40 results about "Glucose fluctuations" patented technology

The invention discloses a use of lactobacillus plantarum ST-III in preparation of an alpha-glucosidase inhibitor or the preparation of a fermented bean product with alpha-glucosidase inhibition activity. The invention further discloses fermented soymilk or fermented beans with the alpha-glucosidase inhibition activity, which can be obtained by inoculating the lactobacillus plantarum ST-III into sterile soymilk or cooked soymilk and fermenting at the temperature of 25-40 DEG C. Water is added into the fermented beans for homogenizing, the pH value is regulated to 6.5-7.5, the boiling is performed for 10-60 minutes, cooling is performed, then solid-liquid separation is performed, and a liquid phase is taken so as to get a water-soluble extract of the fermented soymilk. The lactobacillus plantarum ST-III has high alpha-glucosidase inhibition activity and can be used in glucose-reducing foods, health care products or medicaments. As the oral glucose-reducing foods, the health care products or the medicaments, the high postprandial blood glucose of patients with diabetes can be reduced and the postprandial blood glucose fluctuation can be regulated.

The invention relates to health food capable of lowering decomposition and absorption speeds of starch in bodies and a preparation method thereof. The preparation method is characterized by comprising the steps of adding vegetable powder to normal starch or a starch composition with different digestion rates and preparing starch particles through inclusion for granulation and drying. The health food has the characteristics that as the vegetable powder is added to the starch and serves as a skeleton, not only is the health food abundant in nutrients, but also slow release skeleton powder or particles can be formed, so that decomposition and absorption of the starch is slowed down and the blood glucose can not rise sharply and is in a steady state after people eats the health food; therefore, the postprandial blood glucose is lowered, the probability of various complications caused by blood glucose fluctuation after eating is lowered, and the quality of life of patients with diabetes mellitus is improved.

The invention relates to a technology for reducing in-vivo decomposition and absorption speeds of starch. The technology is characterized by comprising the following steps: crushing starch food raw materials into fine powder or directly utilizing the starch; adding a plant extract and preparing into a soft material by suitable amount of water; then putting the soft material into a double-screw extruder, and extruding into grains by a mould; drying for future use; or after drying the soft material, crushing the soft material into fine powder for future use. The technology has the innovations that the plant extract with an alpha-glucosaccharase inhibition effect is added into the starch so that the deposition and the absorption of the starch slow down; after the starch is eaten, the blood glucose is not suddenly raised and is at a balanced state, so that the postprandial blood glucose is reduced, various complications caused by blood glucose fluctuation after the starch is eaten are reduced and the living quality of diabetics is improved.

The invention discloses an egg-yolk crisp and a production method thereof. The egg-yolk crisp comprises the following raw materials by weight: 30-40% of fresh scatter-feed duck eggs; 5-10% of fructose-glucose syrup; 5-10% of dietary fiber, 18-25% of special flour, millet powder and hulless oat powder; 1-2% of pig leaf lard and peanut oil; and 1-2% of seaweed polysaccharide. The invention has properties of no saccharification and no blood glucose fluctuation, wherein the content of sucrose is zero, and the content of glucose and fructose is zero. The sweetness is low, which is only 45-50% of other corresponding products. The egg-yolk crisp has pure sweet taste, good sweet taste, and no biter taste. Because fat content is low and the oil fat is neutralized with grain fibers, the egg-yolk crisp is delicious but not greasy, and the fat content is 50%-70% of the corresponding traditional products.

The invention discloses continuous blood glucose monitoring equipment comprising a blood glucose classification function fault detection module. According to the equipment, a blood glucose PCA monitoring chart is established to perform fault detection on a continuous blood glucose monitoring instrument so that accurate blood glucose signals can be provided. Due to the influences (such as changes of diets and the emotion of a patient) of external source input, the blood glucose fluctuation condition of the patient can change, and correspondingly the SPE value of the blood glucose signals can change obviously; besides, obvious nonlinearity exists between the blood glucose signals, and thus it is impossible to establish a unified and effective control limit for detecting whether a blood glucose meter has a fault or not. In the equipment, the blood glucose signals are divided into multiple classes, and it is ensured that signals in each class are locally linearized and the blood glucose fluctuation conditions in each class are similar, so that it is ensured that fault detection of the blood glucose meter can be better performed in each class, more accurate and credible data are provided for subsequent blood glucose prediction, control and the like, and the equipment has great significance.

The invention discloses a generalized predictive control closed-loop insulin infusion system based on an adaptive reference curve strategy. The system comprises a blood glucose detection module, a controller, a program module and an insulin pump, the blood glucose detection module is used for acquiring the blood glucose of a user, and an output end of the blood glucose detection module is connected with an input end of the controller through signals. The insulin pump is used for infusing insulin into the user, and an input end of the insulin pump is connected with an output end of the controller through signals. The program module is executed by the controller, acquires the blood glucose of the user through the blood glucose detection module and adjusts the infusion rate of the insulin pump according to a CARIMA (controlled autoregressive integral moving average) model, a minimum variance control algorithm and the adaptive reference curve strategy. According to the generalized predictive control closed-loop insulin infusion system based on the adaptive reference curve strategy, adaptive reference curves can be generated according to blood glucose fluctuation of different patients,so that the infusion rate of the insulin pump can be flexibly controlled.

The invention discloses a meal-replacement fruit-vegetable nutrition bar and a preparation method thereof. The fruit-vegetable nutrition bar contains the following raw materials: konjaku flour, highland barley powder, whey protein powder, fruit-vegetable dices, nut dices, coconut oil, maltitol and mycose. A production process comprises the steps of uniformly mixing dry materials, melting maltitol,uniformly mixing and stirring the materials, kneading dough, and carrying out mold injection, formation, baking, cooling and packaging, so as to obtain a finished product. The meal-replacement fruit-vegetable nutrition bar can be used for replacing normal diet, is capable of supplying required nutrients, low in fat and calorie and balanced in nutrition and does not easily cause food retention andfleshing up. By replacing traditional sugar and syrup with maltitol, the glucose fluctuation is not caused when the flavor is met; by adding the highland barley powder, the nutrition of staple food is guaranteed; by adding the konjaku flour, dietary fibers can be supplied, the satiety can be increased, and low fat and calorie are realized; by adding the fruit-vegetable dices and the like, the nutrition is enriched, and the taste is improved.

The invention discloses a preparation method of green tea and mint-flavored peanuts. The preparation method comprises the following steps: heating and boiling peanuts in a jacketed pan; heating and boiling green tea to obtain filter liquor A; soaking the peanuts with the filter liquor A, and stir-frying until the peanuts are cooked by 30%-45%; heating and boiling mint to obtain filter liquor B, soaking the peanuts with the filter liquor B, and stir-frying until the peanuts are cooked by 50%-60%; heating and boiling bitter tea, peppers, medlar, ligusticum wallichii, lysimachia sikokiana, lysimachia foenum-graecum, zanthoxylum bungeanum, cloves, allspice, thyme, dried orange peels, fennel, cassia twigs and bay leaves, adding the peanuts, soaking, and stir-frying until the peanuts are cooked by 70%-80%; adding salt, cooking wine, taumatin, trehalose, stevioside and monosodium glutamate into water, stirring for heating, adding the peanuts, soaking and drying. The peanuts prepared according to the method are unique in flavor, fresh and cool in mouth feel, fragrant, crisp and delicious; decayed tooth and glucose fluctuation are hardly caused after the peanuts are eaten.

The invention discloses a preparation method for an alpha-glucosidase inhibitor as well as a product and a usage thereof. The preparation method comprises the following steps: centrifugalizing fermented soy bean milk and taking supernatant, extracting the obtained supernatant by using ethyl acetate, depressurizing and evaporating the obtained ethyl acetate-phase to be dry, adding ethyl acetate to prepare an alpha-glucosidase inhibitor crude extraction liquid, separating and eluting the obtained crude extraction liquid by using a silica gel column, testing inhibition of the obtained eluant to alpha-glucosidase, combining and collecting the eluants of component peak according to inhibition effects and freeze-drying to obtain the alpha-glucosidase inhibitor. The invention provides an active ingredient which is separated from a soy bean fermentation product and has obvious inhibition effect to alpha-glucosidase, and offers new ideas for industrial preparation and usage of soy bean fermentation-originated alpha-glucosidase inhibitor. According to the invention, the obtained alpha-glucosidase inhibitor can be directly used in production of products for controlling absorption of carbohydrate in intestinal tract, so as to achieve the purpose of blood glucose fluctuation control.

The invention discloses a diabetes functional beverage gamma balance liquid, belongs to the technical field of food adjunctive therapy, and specifically relates to a functional ecology beverage with significant effects of control of blood glucose and improvement of diabetic complications. The present invention provides a beverage with characteristics of nourishing and relieving by the food, effective control of blood glucose fluctuation, and improvement of symptom complex. According to the present invention, the beverage of the present invention can match the drug treatment, such that the useamount of the drug can be gradually reduced, the side effect can be reduced, the body immunity can be improved, and the symptom complex of the diabetes can be improved; 3000 ml of the diabetes functional beverage of the present invention is prepared by the following components, wherein the components comprise: 200-300 mg of gamma-amino butyric acid (food-grade powder), 3-5 g of ginseng, 5-10 g ofobtuseleaf senna seed, 3-5 g of ganoderma lucidum, 5-10 g of mulberry, 3-5 g of corn stigma, 10-15 g of black bean and the balance of water.

The invention belongs to the technical field of medical health, and particularly relates to a blood glucose prediction method and system and application thereof. An existing blood glucose prediction algorithm has high accuracy in the stable blood glucose change stage, but the blood glucose prediction accuracy is obviously reduced in the large blood glucose fluctuation stage (such as postprandial). The invention provides a blood glucose prediction method. The method comprises the following steps: acquiring blood glucose data, carrying out preliminary prediction on a blood glucose value, fusing preliminary prediction results, and displaying a prediction result. The method can be better suitable for blood glucose prediction of different people, and the accuracy is higher.

The invention relates to the technical field of healthcare food, in particular relates to a traditional Chinese medicine composition with a hyperglycemia lowering effect, a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from gynura procumbens and barley seedling. The gynura procumbens and the barley seedling are combined so that the hyperglycemia lowering effect is improved, the hyperglycemia lowering effect is obviously better than the singly used effect of the gynura procumbens or the barley seedling. The prepared traditional Chinese medicine composition is processed into biscuits, the condition that a diabetic has no good table food on the present market is solved, the disadvantages that other product is unsatisfied in effect, high in product cost and bad in taste are solved; and the clinical effect of the product achieves the satisfactory effect through perennial scientific research and clinical experiment, the blood glucose fluctuation can be effectively controlled, the blood glucose is stably lowered, and the effective rate achieves 96%.

The invention provides an evaluation method and evaluation device blood for glucose fluctuation. The method comprises the steps that continuous blood glucose monitoring data, collected at a preset frequency, of multiple monitoring periods are characterized in the form of a matrix, the number of rows of the matrix corresponds to the number of the monitoring periods, the number of columns of the matrix corresponds to the number of the continuous blood glucose monitoring data collected in one monitoring period, and all elements in the matrix are the values of the collected continuous blood glucose monitoring data; gradient calculation is conducted on the matrix so as to obtain a transverse gradient and a longitudinal gradient, wherein the transverse gradient represents the fluctuation situation of the continuous blood glucose monitoring data in all the monitoring periods, and the longitudinal gradient represents the fluctuation situation of the continuous blood glucose monitoring data among all the monitoring periods; a gradient variation value is calculated based on the transverse gradient and the longitudinal gradient, and then the fluctuation amplitude and the fluctuation frequencyof blood glucose are evaluated through the gradient variation value. With the method and the device, the fluctuation amplitude and the fluctuation frequency of blood glucose can be evaluated at the same time through the gradient variation value, and hypoglycemia can be effectively predicted.

The invention discloses a preparation method and application for a burdock polysaccharide pyrolysate. The preparation method comprises the following steps: adding burdock polysaccharide and water into a reactor, and carrying out pyrolysis at a pyrolysis temperature of 100 to 260 DEG C for 1 to 8 hours so as to obtain a mixed solution; centrifuging the mixed solution for 1 to 5 minutes, taking a supernatant and carrying out concentrating, then carrying out dialysis with a dialysis bag so as to obtain a retention solution, and drying the retention solution so as to obtain the burdock polysaccharide pyrolysate. The preparation method provided by the invention solves the problems of nonuniform structure, low purity, low activity and unstable activity of conventional burdock polysaccharide; the preparation process has less steps and easy operation and is likely to realize large-scale industrial production; the burdock polysaccharide pyrolysate obtained by using the preparation method provided by the invention can significantly inhibit the activity of alpha-glucosidase, significantly reduces the content of blood glucose in mammalian serum, does not generate adverse effects like hepatotoxicity, nephrotoxicity and frequent blood glucose fluctuation, has good curative effects, is non-toxic, and can be applied to hypoglycemic drugs for the needs of clinic treatment of diabetes.

The invention discloses an early detection management system and an early detection management method for a diabetic complication risk. The early detection management method comprises the steps of: step 1, performing blood glucose detection at first; step 2, performing dynamic blood glucose detection; step 3, performing iontophoresis blood glucose detection; step 4, and analyzing blood samples. The early detection management system and the early detection management method for the diabetic complication risk reduce the blood glucose fluctuations and reduce the occurrence rate of the diabetic complication risk through adopting the blood sample analysis and common blood glucose detection means which are combined and supplemented with each other, thereby truly realizing the effect that the diabetic complications can be controlled and prevented.

The invention provides fine dried noodles suitable for people with hyperglycemia to eat and a preparation method of the fine dried noodles. The fine dried noodles comprise the following raw materialsin arts by weight: 20-40 parts of intact wheat powder, 0-45 parts of wheat flour, 10-15 parts of special potato full-powder, 10-20 parts of vital gluten and 1-3 parts of purified konjak micro-powder.The invention further provides the preparation method of the fine dried noodles. The preparation method comprises the steps of weighing, mixing, dough kneading, fermenting, composite rolling, dough cutting and drying. The fine dried noodles have the advantages that a purpose of delaying increasing of postprandial blood sugar is achieved, risks of various complications due to glucose fluctuation ofa diabetic due to food taking are reduced, the living quality of the diabetic is improved, and nutritional requirements of the diabetic are met; and the noodles prepared by the preparation method taste good, and are suitable for being produced on a large scale.

The invention discloses a generalized predictive control insulin infusion amount calculating method based on an adaptive reference curve strategy. The method includes utilizing real-time monitored human blood glucose data to predict future blood glucose change by using a CARIMA model, and then adopting the minimum variance to control and track the adaptive reference curve and calculate the infusion rate of an insulin pump in real time. The infusion is performed to reduce the blood glucose fluctuation of the human body and control the blood glucose in a predetermined target interval. Compared with the existing generalized predictive control algorithm, the adaptive reference curve strategy adopted can generate the reference curve suitable for different patients according to the blood glucosefluctuations of the patients to achieve control of the infusion rate of the insulin pump.

The invention discloses functional compound starch and a preparation method of the functional compound starch. The functional compound starch comprises starch and dimethyldiguanide. The preparation method comprises the following steps: adding dimethyldiguanide into starch; fully mixing and standing, so that the functional compound starch is obtained. Denaturation of starch is avoided by simply compounding the dimethyldiguanide and the starch, so that resistant starch content is thereby effectively improved. The functional compound starch of the invention can be used for preparing various foods made of flour, such as biscuit, moon cake, bread, noodles, steamed bun and the like. As a kind of functional food rich in resistant starch, the food product is capable of effectively reducing glucose release, slowing blood glucose fluctuation and enhancing satiety; thus, the food product is an ideal option for the people on diet and has certain market prospective.

The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.