7 results about "Fasting insulin" patented technology

The present application relates to the technical field of reversing insulin resistance, and particularly relates to a composition with components for reversing insulin resistance and a preparation method thereof, the composition comprising quercetin, procyanidin, malic acid, magnesium carbonate, zinc lactate and grains, and through synergistic effects of the components, the composition can reduce fasting blood glucose, fasting insulin and insulin resistance index, and improve insulin sensitivity index, and overcomes the problems in the prior art that the components of the traditional Chinese medicine composition are complex, the effective components for reversing insulin resistance and the synergistic mechanism are not clear, and the content of the effective components in the same medicine is not consistent due to the influence of the growth environment, resulting in unpredictable treatment effect.

The present disclosure relates to a use of Lacticaseibacillus rhamnosus FMBL L23004 CNN in the preparation of a medicament for preventing or treating diabetes mellitus. The Lacticaseibacillus rhamnosus FMBL L23004 CNN was deposited with the China Center for Type Culture Collection (CCTCC) on 26 Jun. 2023 under the accession number CCTCC NO: M 20231099. The Lacticaseibacillus rhamnosus FMBL L23004 CNN strain has the effect of inhibiting the activity of α-glucosidase, α-amylase, and dipeptidyl peptidase IV. Administration of the strain can significantly lower oral glucose tolerance and insulin tolerance in Type 2 Diabetes Mellitus (T2DM) mice, reduce abnormal postprandial blood glucose fluctuations, decrease fasting blood glucose levels, lower fasting insulin levels, reduce blood lipid levels, and alleviate insulin resistance. The strain significantly improves the composition of the gut microbiome, increases the abundance and diversity of beneficial gut bacteria, and reduces the relative abundance of pathogenic bacteria.

This invention discloses the application of verbascoside in the preparation of drugs for treating obesity and related metabolic disorders, relating to the field of biopharmaceuticals. The drug upregulates the expression of phosphorylated AMP-activated protein kinase α and carnitine palmitoyltransferase-1α, while downregulating the expression of sterol regulatory element-binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase. This application is the first systematic study of the comprehensive intervention effect of verbascoside on diet-induced obesity and related metabolic disorders. In an in vivo obese mouse model, it was demonstrated that verbascoside can significantly inhibit excessive weight gain induced by a high-fat diet, reduce fasting blood glucose and fasting insulin levels, improve dyslipidemia indicators including triglycerides, total cholesterol, non-esterified fatty acids, and low-density lipoprotein cholesterol, enhance insulin sensitivity, and alleviate macrovesicular steatosis and hepatocellular damage.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine preparation for treating metabolic syndrome, which is prepared from the following raw material medicines in parts by weight: 10-20 parts of lotus leaf, 5-15 parts of hawthorn, 5-15 parts of salvia miltiorrhiza, 10-20 parts of cassia seed, 5-15 parts of chrysanthemum, 20-40 parts of corn stigma, 5-15 parts of mulberry leaf, 10-20 parts of poria cocos, 5-15 parts of rhizoma alismatis, 5-15 parts of burdock root, 15-25 parts of fried radish seed and 20-40 parts of raw malt. According to the traditional Chinese medicine composition, heat clearing, diuresis promoting, digestion promoting and stagnation removing are adopted as methods, and the effects of heat clearing, diuresis promoting, digestion promoting and stagnation removing and blood circulation promoting and blood stasis removing are achieved through combination of all the medicine materials for the damp-heat accumulation type metabolic syndrome. Clinical research shows that the total effective rate of the traditional Chinese medicine composition is 75.93% when the traditional Chinese medicine composition is combined with conventional western medicines to treat the metabolic syndrome and is remarkably superior to that of a pure western medicine control group (53.70%); the blood pressure, the body mass index, the waist-hip ratio, the fasting blood glucose, the fasting insulin, the insulin resistance index and the blood fat level of a patient can be remarkably reduced, the high-density lipoprotein cholesterol can be increased, and obvious adverse effects are avoided. The traditional Chinese medicine composition is precise and appropriate in formula, exact in curative effect and high in safety, and has a good clinical application prospect.

This invention provides a compound composition for regulating glucose and lipid metabolism in diabetes and its application, belonging to the fields of medicine, food, and health products. The composition comprises an enzymatically hydrolyzed extract of Polygonatum sibiricum, a compound extract of traditional Chinese medicine including Astragalus membranaceus, ginseng, mulberry leaf, cinnamon, white kidney bean, and bitter melon, probiotics including Lactobacillus rhamnosus and Bifidobacterium bifidum B11, hydrolyzed collagen peptides, and tagatose, scientifically formulated according to the principles of traditional Chinese medicine. This composition can comprehensively regulate the multidimensional pathological characteristics of diabetes, such as glucose and lipid metabolism disorders, chronic inflammation, and weight loss, exerting a synergistic effect. Its hypoglycemic, lipid-regulating, anti-inflammatory, and weight-recovery-promoting effects are significantly better than the sum of the individual effects of each component. It can also significantly improve serum free fatty acid, fasting insulin, and inflammatory factor levels, providing a new approach for developing safe and effective adjunctive treatment products for diabetes.

The invention relates to the technical field of pregnant woman delivery time prediction, in particular to a pregnant woman delivery time prediction system based on big data analysis, and the system carries out the weighted fusion of the ratio of the abdominal circumference of a fetus to the femur length, a fetus weight estimation value and a fetus weight increase rate to obtain a fetus metabolic load index; calculating to obtain an insulin resistance index change rate according to the fasting insulin level and the fasting blood glucose level; calculating the blood glucose fluctuation amplitude of the continuous blood glucose monitoring data of the maternal body, and calculating the area abnormal increment under the blood glucose curve; analyzing the blood glucose fluctuation amplitude, the insulin resistance index change rate and the abnormal increment of the area under the blood glucose curve to obtain a maternal metabolic stress index; and when a dynamic imbalance critical value obtained by carrying out load-stress imbalance analysis on the fetal metabolic load index and the maternal metabolic stress index exceeds a preset dynamic imbalance critical threshold value, generating predicted delivery time and outputting early warning information. And the accuracy of predicting the delivery time of the pregnant woman with the gestational diabetes mellitus is effectively improved.

The invention provides a compound composition for regulating glycolipid metabolism of diabetes and application of the compound composition, and belongs to the technical field of medicines, foods or health-care products. The composition is prepared from a rhizoma polygonati enzymolysis extract, a traditional Chinese medicine compound extract comprising astragalus membranaceus, ginseng, mulberry leaves, cinnamon, white kidney beans and bitter gourds, probiotics comprising rhamnolactobacilli and bifidobacterium bifidum B11, hydrolyzed collagen peptide and tagatose through scientific compatibility according to the principle of monarch, minister, assistant and guide in traditional Chinese medicine. The composition can realize comprehensive regulation of multi-dimensional pathological characteristics such as glucose and lipid metabolism disorder, chronic inflammation and weight loss of diabetes mellitus, exerts a synergistic effect, and has the effects of reducing blood glucose, regulating lipid, resisting inflammation and promoting weight recovery obviously superior to the superposition of independent effects of the components; the levels of free fatty acid, fasting insulin and inflammatory factors in serum can be remarkably improved, and a new scheme is provided for developing safe and effective diabetes adjuvant therapy products.