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Diaphragma juglandis phenol extract and application thereof in preparation of medicine for preventing abnormal glucose and lipid metabolism

A technology of walnut heartwood and glucose and lipid metabolism, which is applied in the fields of application, metabolic diseases, drug combination, etc., can solve the problems that have not been effectively developed and utilized, and achieve the effect of preventing abnormal activity of glucose and lipid metabolism and reducing the degree of damage

Pending Publication Date: 2022-04-19
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the rapid growth of walnut cultivation area and output, a large amount of distracting wood has been produced, but it has not been effectively developed and utilized

Method used

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  • Diaphragma juglandis phenol extract and application thereof in preparation of medicine for preventing abnormal glucose and lipid metabolism
  • Diaphragma juglandis phenol extract and application thereof in preparation of medicine for preventing abnormal glucose and lipid metabolism
  • Diaphragma juglandis phenol extract and application thereof in preparation of medicine for preventing abnormal glucose and lipid metabolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Select complete fresh walnuts, wash them, peel them, remove the nuclei, take the heartwood, dry them, crush them, and pass through a 60-mesh sieve to get the walnut heartwood powder. Weigh the split wood powder, add edible ethanol with a volume fraction of 55% according to the ratio of solid to liquid 1:30, reflux and extract at 80°C for 80 minutes, filter, extract twice, combine the filtrate, and let stand. Put the upper supernatant of the filtrate in a centrifuge, centrifuge at a speed of 25,000r / min for 5min, take the centrifuged supernatant, concentrate it under reduced pressure until it has no alcohol smell, and vacuum freeze-dry the concentrated solution to obtain the extract of walnut cardigols powder; using NaNO 2 -Al(NO 3 ) 3 The flavonoid content in the obtained phenolic extract was determined by colorimetry to be 64.5%.

Embodiment 2

[0027] Select complete fresh walnuts, wash them, peel them, remove the nuclei, take the heartwood, dry them, crush them, and pass through a 60-mesh sieve to get the walnut heartwood powder. Weigh the fenugreek powder, add edible ethanol with a volume fraction of 50% according to the ratio of solid to liquid 1:40, reflux and extract at 80°C for 100 minutes, filter, extract twice, combine the filtrate, and let stand. Put the upper supernatant of the filtrate in a centrifuge, centrifuge at a speed of 30,000r / min for 10min, take the centrifuged supernatant, concentrate it under reduced pressure until it has no alcohol smell, and vacuum freeze-dry the concentrated solution to obtain the extract of walnut cardigol powder; using NaNO 2 -Al(NO 3 ) 3 The flavonoid content in the obtained phenolic extract was determined by colorimetry to be 65.32%.

Embodiment 3

[0029] Select complete fresh walnuts, wash them, peel them, remove the nuclei, take the heartwood, dry them, crush them, and pass through a 60-mesh sieve to get the walnut heartwood powder. Weigh the split wood powder, add edible ethanol with a volume fraction of 60% according to the ratio of solid to liquid 1:35, reflux and extract at 80°C for 60 minutes, filter, extract twice, combine the filtrate, and let stand. Put the upper supernatant of the filtrate in a centrifuge, centrifuge at a speed of 265,000r / min for 9min, take the centrifuged supernatant, concentrate it under reduced pressure until it has no alcohol smell, and vacuum freeze-dry the concentrated solution to obtain the extract of walnut cardigols powder; using NaNO 2 -Al(NO 3 ) 3 The flavonoid content in the obtained phenolic extract was determined by colorimetry to be 66.1%.

[0030] The research on the preventive effect of the obtained walnut carrageenol extract on abnormal glucose and lipid metabolism shows...

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Abstract

The invention discloses a walnut diaphragma juglandis phenolic extract, which is characterized in that the content of flavone in the phenolic extract is 64.5-66.1%, the walnut diaphragma juglandis phenolic extract has the effect of preventing abnormal glucose and lipid metabolism, and the phenolic extract is obtained by pretreatment, extraction, separation, concentration, drying and determination. The walnut diaphragma juglandis phenol low-dose extract and the walnut diaphragma juglandis phenol high-dose extract can remarkably inhibit impairment of oral glucose tolerance of a model animal with abnormal glucose and lipid metabolism, remarkably reduce the damage degree of OGTT, remarkably inhibit increase of AUC, glycated serum protein GSP, fasting blood glucose FBG, fasting insulin FINS, insulin resistance index HOMA-IR and insulin sensitivity index ISI, and can be used for preparing the medicine for treating the abnormal glucose and lipid metabolism. The rise of serum total triglyceride TG, total cholesterol TC and low-density lipoprotein cholesterol LDL-C level and the reduction of the low-density lipoprotein cholesterol HDL-C level of a model animal with abnormal glucose and lipid metabolism are obviously inhibited. The walnut diaphragma juglandis phenol extract is high in flavone content and can be used as a food or feed additive and a human or animal medicine raw material.

Description

technical field [0001] The invention belongs to the technical field of utilization of biological resources, and in particular relates to a walnut cardigol extract and its application in products for preventing abnormal glucose and lipid metabolism. Background technique [0002] distraction wood ( Diaphragma Juglandis Fructus), also known as walnut septum, walnut coat, nutcracker, walnut septum, is a member of the Juglandaceae ( Juglandaceae ) Plant Juglans ( Juglans regia L. ) of the wooden diaphragm. Chinese medicinal properties: It tastes bitter and astringent, flat in nature, and non-toxic; it enters the spleen and kidney meridians; Control nocturnal emission and slippery diarrhea, gonorrhea, hematuria, drowning, metrorrhagia, leucorrhea, and diarrhea. Modern biological research shows that distracted wood mainly contains alkaloids, volatile oils, phenolic compounds, tannins, oils, amino acids, saponins, sugars, organic acids, polypeptides or proteins, etc. Lipid a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P3/10A61P3/06A23L33/105A23K10/30A23K20/111
CPCA61K36/52A61P3/10A61P3/06A23L33/105A23K10/30A23K20/111A23V2002/00A23V2200/328A23V2200/3262A23V2250/2132
Inventor 赵声兰张凤陈丹赵庆宇婧张希林玉萍马雅鸽
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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