The invention discloses body-building and health-care medicinal liquor. A preparation method of the body-building and health-care medicinal liquor comprises the following steps of respectively crushing raw materials of cynomorium songaricum, drgon's bone, cistanche, fleece-flower root, Chinese yam, milkvetch root, morinda officinalis, epimeddium, Chinese eaglewood, semen astragali complanati, sharpleaf galangal fruit, curculigo orchioides, malaytea scurfpea fruit, red raspberry, cortex acanthopanacis, clove, himalayan teasel root, cherokee rose fruit, actinolite, cassia bark, cortex eucommiae, coral skeleton, tuber onion seeds, Chinese magnoliavine, Chinese glossy privet, dried longan pulp, wolfberry, prepared radix aconiti lateralis preparata, semen cuscutae, gecko, sea horse and corn cervi pantotrichum, uniformly mixing the crushed raw materials, adding an appropriate amount of honey into the mixture, uniformly stirring, steaming, and immersing the steamed mixture in liquor. The body-building and health-care medicinal liquor has good effects of tonifying kidney and controlling nocturnal emission, invigorating yang, tonifying qi, tonifying yin, resisting fatigue and improving immunity.