The invention provides a graphene neurasthenia Yao medicine patch and a preparation method thereof. The preparation method includes steps: (1) taking herba speranskiae tuberculatae, rhizoma dioscoreae, herba menthae, flos albiziae, radix curcumae and cortex phellodendri, grinding, mixing, screening, adding distilled water and phosphate buffer, well stirring, adding cellulase and pectinase, stirring, centrifuging, collecting supernatant, concentrating and drying to obtain Yao medicine enzymolysis extract; (2) dispersing graphene powder into Yao medicine enzymolysis extract aqueous solution, ultrasonically treating, stirring, dropwise adding gelatin solution, stirring and standing to obtain graphene-gelatin medicine-carrying hydrogel; (3) well stirring a product obtained in the step (2), pouring into a mould, solidifying and setting to obtain the graphene neurasthenia Yao medicine patch. By combination of a Yao medicine neurasthenia treating composition and a graphene material, hydrogelis prepared and applied to the patch to give the full play to efficacies of the Yao medicine composition, convenience in adsorption is achieved, and great treatment effects are realized.