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Graphene neurasthenia Yao medicine patch and preparation method thereof

A neurasthenia and graphene technology, applied in pharmaceutical formulations, nervous system diseases, drug combinations, etc., can solve the problems of easy formation of addiction and drug resistance, long period of psychological treatment, and insignificant effects, and achieve water absorption. Strong, fast-acting, low-cost effects

Inactive Publication Date: 2018-09-21
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in the treatment of neurasthenia, western medicine generally focuses on psychotherapy and taking western medicines. The psychotherapy cycle is long and the effect is not obvious; Suleazepam, Jiannao Mixture, etc.; these drugs have defects in safety and dependence, relatively large side effects, and easy to form addiction and drug resistance
There are many medicines in traditional Chinese medicine that have certain curative effects on neurasthenia, but there are also some problems, such as difficulty in choosing medicines, etc.

Method used

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  • Graphene neurasthenia Yao medicine patch and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0024] The preparation of embodiment 1 graphene neurasthenia medicine patch

[0025] Follow the steps below:

[0026] (1) Extraction of medicinal materials: get 20 parts of Speranthema japonicus, 20 parts of Chinese yam, 15 parts of peppermint, 10 parts of Albizia juniperus, 10 parts of turmeric, 4 parts of Cortex Phellodendri in parts by weight, pulverize, mix, sieve, and the Chinese medicine powder of gained is pressed Mix 1:20 with distilled water, stir evenly, add phosphate buffer according to 1:20 ratio of traditional Chinese medicine powder and phosphate buffer, buffer pH=7.5, add 300U / g cellulase, 250U / g pectinase, 50℃ Stir and react at a temperature of 50r / min for 4h, after the reaction is completed, centrifuge at a speed of 5000r / min for 40min, collect the supernatant, concentrate, and dry to obtain the enzymatic hydrolyzed extract of Yao medicine with a yield of 65%;

[0027] (2) Preparation of graphene-based drug-loaded gel: disperse 200mg of graphene powder in 1L ...

Embodiment 2

[0029] The preparation of embodiment 2 graphene neurasthenia drug patch

[0030] Follow the steps below:

[0031] (1) Extraction of medicinal materials: get 18 parts by weight of Sperantosporum, 17 parts of Chinese yam, 13 parts of Peppermint, 7 parts of Juan Juan, 7 parts of Curcuma, 2 parts of Phellodendron Phellodendri, pulverize, mix, sieve, the Chinese medicine powder of gained presses Mix with distilled water at 1:10, stir evenly, add phosphate buffer according to the ratio of traditional Chinese medicine powder and phosphate buffer at 1:10, buffer pH=6.5, add 100U / g cellulase, 150U / g pectinase, 50℃ The temperature was stirred at 100r / min for 3h, the reaction was completed, centrifuged at 2000r / min for 20min, the supernatant was collected, concentrated, and dried to obtain the enzymatic hydrolyzed extract of Yao medicine with a yield of 93%;

[0032] (2) Preparation of graphene-based drug-loaded gel: disperse 200mg of graphene powder in 1L of Yaoyao enzymolysis extract ...

Embodiment 3

[0034] The preparation of embodiment 3 graphene neurasthenia drug patch

[0035] Follow the steps below:

[0036] (1) Extraction of medicinal materials: get 15 parts by weight of Sperantosporum, 15 parts of Chinese yam, 10 parts of Peppermint, 5 parts of Albizia Julibrissin, 5 parts of Curcuma, 2 parts of Phellodendron Phellodendri, pulverize, mix, sieve, the Chinese medicine powder of gained presses Mix 1:5 with distilled water, stir evenly, add phosphate buffer according to 1:5 of traditional Chinese medicine powder and phosphate buffer, buffer pH=5.5, add 80U / g cellulase, 100U / g pectinase, 50℃ Stir and react at a temperature of 80r / min for 2h, after the reaction is completed, centrifuge at a speed of 1500r / min for 10min, collect the supernatant, concentrate, and dry to obtain the enzymatic hydrolysis extract of Yao Yao, with a yield of 71%;

[0037] (2) Preparation of graphene-based drug-loaded gel: disperse 200mg of graphene powder in 1L of Yaoyao enzymolysis extract aque...

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Abstract

The invention provides a graphene neurasthenia Yao medicine patch and a preparation method thereof. The preparation method includes steps: (1) taking herba speranskiae tuberculatae, rhizoma dioscoreae, herba menthae, flos albiziae, radix curcumae and cortex phellodendri, grinding, mixing, screening, adding distilled water and phosphate buffer, well stirring, adding cellulase and pectinase, stirring, centrifuging, collecting supernatant, concentrating and drying to obtain Yao medicine enzymolysis extract; (2) dispersing graphene powder into Yao medicine enzymolysis extract aqueous solution, ultrasonically treating, stirring, dropwise adding gelatin solution, stirring and standing to obtain graphene-gelatin medicine-carrying hydrogel; (3) well stirring a product obtained in the step (2), pouring into a mould, solidifying and setting to obtain the graphene neurasthenia Yao medicine patch. By combination of a Yao medicine neurasthenia treating composition and a graphene material, hydrogelis prepared and applied to the patch to give the full play to efficacies of the Yao medicine composition, convenience in adsorption is achieved, and great treatment effects are realized.

Description

technical field [0001] The invention relates to the technical field of medicines for treating neurasthenia, in particular to a graphene neurasthenia drug patch and a preparation method thereof. Background technique [0002] Neurasthenia is mainly the symptoms of mental and physical weakness, easily excitable and mentally fatigued; it is mainly manifested as a disorder of high-level neural activity in the brain, which is characterized by a lack of mental and physical strength, fatigue, and low work efficiency. Organic disease exists. It is often accompanied by dizziness, headache, vertigo, tinnitus, palpitations, back pain, irritability, difficulty falling asleep, dreaminess and easy waking, insomnia and forgetfulness, premature ejaculation and impotence, and may be accompanied by mild depression or anxiety. [0003] With the rapid development of society and the continuous acceleration of people's life rhythm, people's life, study, and work pressure are increasing. Many youn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/06A61K47/04A61K47/42A61P25/00
CPCA61K9/0014A61K9/06A61K36/185A61K36/47A61K36/48A61K36/534A61K36/756A61K36/8945A61K36/9066A61K47/02A61K47/42A61K2236/19A61P25/00A61K2300/00
Inventor 唐农赵立春
Owner GUANGXI UNIV OF CHINESE MEDICINE
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