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Application of pharmaceutical composition to preparation of medicines for treating type 2 diabetes mellitus

A type 2 diabetes and drug technology, applied in the field of pharmaceutical composition in the preparation of drugs for the treatment of type 2 diabetes, can solve the problems of no type 2 diabetes, reduce insulin resistance, regulate glucose and lipid metabolism, and simplify medication Effect

Inactive Publication Date: 2018-10-09
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the combination of Coptis chinensis and Evodia rutaecarpa for the treatment of type 2 diabetes

Method used

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  • Application of pharmaceutical composition to preparation of medicines for treating type 2 diabetes mellitus
  • Application of pharmaceutical composition to preparation of medicines for treating type 2 diabetes mellitus
  • Application of pharmaceutical composition to preparation of medicines for treating type 2 diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0025] Take 2 parts of Coptis chinensis and 1 part of Evodia rutaecarpa. Weigh each herbal flavor according to the amount, mix with sufficient amount of water, and decoct with low heat for more than 30 minutes. After collecting the decoction, decoct with water for 2 more times, and combine each decoction to obtain the decoction.

Embodiment 2

[0026] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0027] Get the decoction prepared in Example 1, after concentrating, add appropriate amount of starch and dextrin and mix evenly before granulating.

Embodiment 3

[0028] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0029] Take 2 parts of Coptis chinensis and 1 part of Evodia rutaecarpa. Weigh each herbal flavor according to the amount, mix with sufficient amount of water, and decoct with low heat for more than 30 minutes. After collecting the decoction, decoct with water for 2 times, combine each decoction, dry, add appropriate amount of dextrin and soluble starch to granulate, and press into tablets to obtain tablets.

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Abstract

The invention provides application of a pharmaceutical composition to preparation of medicines for treating type 2 diabetes mellitus, and the pharmaceutical composition is prepared from the followingraw materials by a weight ratio: 2-10 parts of rhizoma coptidis and 1-10 parts of fructus evodiae. The composition provided by the invention can effectively improve the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and OGTT2h plasma glucose (OGTT2hPG) in patients with the type 2 diabetes mellitus, and does not have an adverse effect; therefore, a new choice is provided for clinical medication.

Description

technical field [0001] The invention relates to the application of a pharmaceutical composition in the preparation of medicine for treating type 2 diabetes. Background technique [0002] Diabetes mellitus is a chronic metabolic disorder with high morbidity and multiple etiologies. It is clinically divided into type 1 and type 2, with type 2 patients being the majority. Type 2 diabetes is characterized by peripheral insulin resistance. At the molecular level, it is manifested by the loss of signal transduction after insulin binds to insulin receptors, causing persistent hyperglycemia, resulting in increased oxidative stress, and various chronic complications. [0003] Since the etiology and pathogenesis of diabetes are not yet fully understood, there is still a lack of effective etiological treatments. Various types of anti-type 2 diabetes chemical drugs have been used in clinical treatment in the market, mainly including sulfonylureas, biguanides, glucosidase inhibitors, in...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P3/10A61P5/50
CPCA61K36/718A61K36/754A61K2300/00
Inventor 扈晓宇李艳歌
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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