The invention provides nutritive formula powder suitable for increasing muscles of old people and a preparation method of the nutritive formula powder. The nutritive formula powder comprises the efficacy components of nonfat dry milk powder, protein powder, calcium beta-hydroxy-beta-methyl-butyrate, sunflower oil powder, glucose syrup powder, fine white granulated sugar / cane sugar, fructo-oligosaccharide, galactooligosaccharide, a grape seed extract, a cucumber seed extract, a vitamin premix, a trace element premix, and a mineral premix. The nutritive formula powder is obtained in a mixing manner, particularly the calcium beta-hydroxy-beta-methyl-butyrate is added, and the components are in synergism, so that nutrient requirements of the old people can be met, concentration of amino acidsnecessary for blood is increased, the synthesis of muscle protein is stimulated, the net synthesis level of the protein of the old people is increased, the nutrient requirements of crowds with sarcopenia are met, and the nutritive formula powder can treat or prevent sarcopenia.