Traditional Chinese medicine composition for treating simple obesity, and preparation method and application thereof

A simple obesity and composition technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of overall improvement of the body's metabolic function, unsustainable curative effect, and rebound

Inactive Publication Date: 2013-07-31
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing problems of traditional Chinese medicine in this field are: failure to theoretically clarify the TCM category of obesity; one-sided emphasis on the application and role of a single treatment method in weight loss, and failure to fundamentally regulate the whole body and improve the body's health. Metabolic function; although the l

Method used

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  • Traditional Chinese medicine composition for treating simple obesity, and preparation method and application thereof
  • Traditional Chinese medicine composition for treating simple obesity, and preparation method and application thereof
  • Traditional Chinese medicine composition for treating simple obesity, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 50g of Atractylodes macrocephala, 100g of broiled turtle shell, 100g of Inula inula, 100g of curcuma, and 100g of Polygonum cuspidatum. Broken soft-shelled tortoiseshell, add 1L water and fry for 30 minutes, then add other medicinal materials; add 4.5L water to decoct and extract for 1 hour, add 3.6L water to decoct and extract for 30 minutes, combine the two decoction extracts, Filter and concentrate to a relative density of 1.40 at 20°C; centrifuge at a speed of 3000r / min; spray dry at 60°C to obtain a dry extract.

Embodiment 2

[0037] Weigh 300g of Atractylodes macrocephala, 300g of broiled turtle shell, 200g of Inula inula, 200g of curcuma, and 200g of Polygonum cuspidatum. Crack the turtle shell and add 3L water to decoct for 30 minutes, then add other medicinal materials; add 12L water to decoct and extract for 1 hour, add 9.6L water to decoct and extract for 30 minutes in the second decoction, combine the two decoction extracts, and filter , concentrated to a relative density of 1.4 at 20°C; centrifuged at a speed of 3000r / min; spray-dried at 50°C to obtain a dry extract.

Embodiment 3

[0039] Weigh 300g of Atractylodes macrocephala, 300g of broiled turtle shell, 150g of Inula inula, 150g of curcuma, and 150g of Polygonum cuspidatum. Broken soft-shelled turtle shells, add 3L water and fry for 30 minutes, then add other medicinal materials; add 10.5L water to decoct for 1 hour, add 8.4L water to decoct and extract for 30 minutes, combine the two decoction extracts, Filter and concentrate to a relative density of 1.40 at 20°C; centrifuge at a speed of 3000r / min; spray dry at 60°C to obtain a dry extract.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating simple obesity, and a preparation method and an application thereof. The traditional Chinese medicine composition is prepared by using 5-30 parts by mass of white atractylodes rhizome, 10-30 parts by mass of fried turtle shell, 10-20 parts by mass of inula flowers, 10-20 parts by mass of curcuma zedoary and 10-20 parts by mass of giant knotweed rhizome as raw materials. Specifically, the preparation method comprises the following steps of weighing all medicines according to the above proportions; smashing the fried turtle shell; adding water 10 times by volume that of the fried turtle shell; decocting for 30 minutes; adding traditional Chinese medicinal materials; adding water and decocting for two times, wherein the volume of added water in each time is 8-10 times that of a total mass of the medicines; and the time for each decoction is 0.5-1 hour; merging extract solutions obtained by the two times of decoction; filtering, concentrating, and drying to obtain a dry extract. Animal experiments show that the composition can significantly reduce body weight, liver weight and fat weight of high-fat obese rats, significantly reduce the contents of liver cholesterol and liver triglyceride in the high-fat obese rats, regulate lipid metabolism and improve liver functions. The medicine effects are related to the fact that the composition can increase bile flow, regulate and increase bile acid subfractions that can promote bile secretion and the lipid metabolism.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating simple obesity, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Obesity and its closely related hyperlipidemia, diabetes, cardiovascular disease and cancer have become global medical and social problems. WHO defines obesity as a serious chronic metabolic disease. Among them, simple obesity accounts for more than 90%. Western medicine currently treats obesity mainly with appetite suppressants, drugs that affect digestion and absorption, and hormone drugs that accelerate metabolism. However, severe side effects such as steatosis and subcutaneous fat mound, liver function damage, dependence and rebound are common. At present, the traditional Chinese medicine understanding of obesity is mostly based on the ancients' elaboration on the aspects of "ointment", "fat man" and "meat ma...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P3/04A61K35/56A61K35/586
Inventor 杨柏灿方瑜李风华李德刚高敏李晓芸林宇东沙妙倩孙苏圆
Owner SHANGHAI UNIV OF T C M
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