The invention discloses a special compound feed for industrial aquaculture of penaeus monodon. The special compound feed comprises the following components in percentage by weight: 20%-25% of fish meal, 5%-8% of dephenolized cottonseed protein, 6%-10% of artemia powder, 6%-6.7% of degreased silkworm chrysalis meal, 6%-12% of scallop skirt powder, 3%-6% of enzymolysis fish soluble pulp powder, 1%-3% of dried porcine soluble powder, 2%-5% of superfine enteromorpha powder, 3%-6% of schizochytrium limacinum powder, 3%-6% of nannochloropsis oculata powder, 2%-5% of marine red yeast dry powder and the balance of water, 2%-3% of shrimp shell powder, 1%-3% of kelp powder, 7%-10% of flour, 3%-5% of peas, 1.5%-3% of lysolecithin, 1%-1.6% of fish oil, 0.2%-0.4% of taurine, 2%-3.5% of monocalcium phosphate, 0.8075%-1% of vitamin premix and 1.0925%-1.4% of mineral premix. The special compound feed for industrial aquaculture of the penaeus monodon is high in nutritional value, easy to digest, good in curing degree and high in stability, the growth performance, the anti-stress capability, the oxidation resistance and the body color of the penaeus monodon are remarkably improved, and nitrogen and phosphorus emission is reduced.