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Traditional Chinese medicine composition for treating blood stasis type coronary heart disease angina pectoris, and preparation method thereof

A technology of coronary heart disease angina pectoris and composition, which is applied in the field of traditional Chinese medicine composition and its preparation for treating blood stasis type coronary heart disease angina pectoris, and can solve the problems of low content of active ingredients, backward technology, and weak pertinence, etc.

Inactive Publication Date: 2020-04-14
吉林修正药业新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above extraction method is a relatively traditional traditional Chinese medicine preparation method, the technology is relatively backward, the content of active ingredients is low, the onset of effect is slow, the dosage is large, the compliance is poor, the pertinence is not strong, and the indications are not clear enough. Refined Guanxin Tablets take 6- 8 tablets, 3 times a day

Method used

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  • Traditional Chinese medicine composition for treating blood stasis type coronary heart disease angina pectoris, and preparation method thereof
  • Traditional Chinese medicine composition for treating blood stasis type coronary heart disease angina pectoris, and preparation method thereof
  • Traditional Chinese medicine composition for treating blood stasis type coronary heart disease angina pectoris, and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Embodiment 1 Chinese medicine composition I

[0102] 1. A preparation method for treating blood stasis type coronary heart disease angina pectoris Chinese medicine extract A is:

[0103] Take 5 parts of Jiangxiang, 10 parts of Chuanxiong, and 5 parts of safflower, crush them into fine powder, pass through a 40-mesh sieve, add 10 times the amount of water, soak for 0.5 hours, and extract the volatile oil by steam distillation for 5 hours, collect the volatile oil, set aside, and extract with water The liquid was filtered, and the filtrate was concentrated under reduced pressure, dried, and pulverized to obtain powder a.

[0104] Dissolve the volatile oils of Jiangxiang, Ligusticum Chuanxiong, and Safflower in equal volumes of ethanol for later use; weigh β-cyclodextrin with 8 times the amount of volatile oils to make a saturated aqueous solution at 35°C, add volatile oils while stirring, and heat at 35°C Stir continuously under heat preservation for 4 hours, refrigerate...

Embodiment 2

[0116] Embodiment 2 Chinese medicine composition II

[0117] 1. A preparation method for treating blood stasis type coronary heart disease angina pectoris Chinese medicine extract A:

[0118]Take 5 parts of Jiangxiang, 10 parts of Chuanxiong, and 5 parts of safflower, grind them into fine powder, pass through a 40-mesh sieve, add 12 times the amount of water, soak for 2 hours, and extract the volatile oil by steam distillation for 8 hours, collect the volatile oil, set aside, and extract with water The liquid was filtered, and the filtrate was concentrated under reduced pressure, dried, and pulverized to obtain powder a.

[0119] Dissolve the volatile oils of Jiangxiang, Ligusticum Chuanxiong and Safflower in an equal volume of ethanol for later use; weigh β-cyclodextrin with 8 times the amount of volatile oil to make a saturated aqueous solution at 50°C, add volatile oil while stirring, and heat at 50°C Stir continuously under heat preservation for 4 hours, refrigerate for 2...

Embodiment 3

[0131] Embodiment 3 Chinese medicine composition III

[0132] 1. A preparation method for treating blood stasis type coronary heart disease angina pectoris Chinese medicine extract A:

[0133] Take 5 parts of Jiangxiang, 10 parts of Chuanxiong, and 5 parts of safflower, crush them into fine powder, pass through a 40-mesh sieve, add 11 times the amount of water, soak for 1 hour, and extract the volatile oil by steam distillation for 6 hours, collect the volatile oil, set aside, and extract with water The liquid was filtered, and the filtrate was concentrated under reduced pressure, dried, and pulverized to obtain powder a.

[0134] Dissolve the volatile oils of Jiangxiang, Ligusticum Chuanxiong, and Safflower in equal volumes of ethanol for later use; weigh β-cyclodextrin with 8 times the amount of volatile oils to make a saturated aqueous solution at 45°C, add volatile oils while stirring, and heat at 40°C Stir continuously under heat preservation for 4 hours, refrigerate for...

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Abstract

The invention relates to the technical field of medicine extraction, particularly to a traditional Chinese medicine composition for treating blood stasis type coronary heart disease angina pectoris, and a preparation method thereof. According to the invention, by carrying out extraction, refining and pharmacodynamic screening on the effective parts in five medicinal materials of salvia miltiorrhiza, radix paeoniae rubra, ligusticum wallichii, safflower carthamus and lignum dalbergiae odoriferae in a prescription, the original dosage form is modified into the traditional Chinese medicine composition consisting of extracted effective components; the pharmacodynamic experiment results prove that the traditional Chinese medicine composition prepared by the invention is remarkable in medicine effect, high in bioavailability and stable and reliable in quality; and the traditional Chinese medicine composition can be prepared into different dosage forms according to the requirements of patients, and is convenient to carry and easy to take.

Description

technical field [0001] The invention relates to the technical field of medicine extraction, in particular to a traditional Chinese medicine composition for treating angina pectoris of blood stasis type coronary heart disease and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the prevalence of various diseases that seriously threaten human life is increasing year by year, among which the incidence of cardiovascular disease is showing a clear upward trend. According to the statistics of heart disease and epidemiology released by the American Heart Association in 2017 Data show that 31% of deaths worldwide are caused by cardiovascular diseases, among which coronary heart disease and angina pectoris are one of the important causes of disability and death of patients with cardiovascular diseases, which seriously threaten human health. There are many kinds of medicines in China, but most of them are chemically synthes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K47/69A61P9/10
CPCA61K36/236A61K36/286A61K36/48A61K36/537A61K36/65A61K36/71A61K2236/331A61K2236/333A61K2236/37A61K2236/53A61K2236/55A61K47/6951A61P9/10A61K2300/00
Inventor 李双石菊徐建赵伯友王鑫孙巍张颖杨喆茗
Owner 吉林修正药业新药开发有限公司
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