210results about How to "High medical value" patented technology

The invention provides a method of producing worm grass lotus seeds by virtue of solid state fermentation of lotus seeds. The method comprises the following steps: on the basis of utilizing the steamed lotus seeds as a worm grass solid state fermentation culture medium, inoculating 3-8ml worm grass liquid strain to per 100 g of the lotus seeds; culturing for 10-30 days at the temperature of 5-30 DEG C and the humidity of 60-90% in dark, namely obtaining worm grass lotus seeds on which hyphae are overgrown; and culturing the worm grass lotus seeds on which the hyphae are overgrown at the temperature of 5-30 DEG C and the humidity of 80-95% for 10-30 days with the illumination of 8-15 hours per day, thus obtaining the worm grass lotus seeds on which worm grass sporocarps are grown. The invention provides a new worm grass source and a new lotus seed health food. According to the invention, the medical effect of worm grass and the nutrition of the lotus seeds are organically combined, so that the product has various nutrient components, is especially rich in active components such as cordycepin, a cordycepic acid, a worm grass polyose and the like and has high edible and medical values; and the worm grass lotus seed fungus preparation process is simple and can easily realize large-scale production, popularization and implementation.

The invention discloses a green mud crab antibacterial peptide Sphistin and application thereof, relates to the technical field of genetic engineering of crustaceans, and provides the green mud crab antibacterial peptide Sphistin and the application thereof. A molecular formula of the green mud crab antibacterial peptide Sphistin is C170H293N61O46S1 and molecular weight of the green mud crab antibacterial peptide Sphistin is 3,959.61 Dalton. The antibacterial peptide Sphistin consists of 38 amino acids, is derived from a part of sequences at end N of green mud crab histone 2A protein and is apolypeptide with an antibacterial function. By adopting the conventional solid-phase chemical synthesis method, the green mud crab antibacterial peptide Sphistin with purity of over 95 percent can beobtained. The green mud crab antibacterial peptide Sphistin has an obvious antibacterial effect on various gram negative bacteria and gram positive bacteria, has a broad antibacterial spectrum and high sterilization rate, shows extremely high medical value and is excellently applied to preparing antibacterial agents.

The invention provides a biodegradable cardia support. The biodegradable cardia support comprises a biodegradable support framework which is formed by weave of biodegradable high polymer material filaments, and a layer of controlled-release drug layer is coated on the surface of the biodegradable support framework. The support framework and drug carriers are made of high polymer biodegradable materials and can fully and automatically degradate after time window treatment is finished, and therefore the trouble of taking out the support is avoided. In addition, the controlled-release drug layer can release anti-inflammatory drugs stably through drug controlled-release technology, and therefore fibroblast hyperplasia caused by esophagus repair reaction can be effectively restrained, subsequent scar tissue hyperplasia and thickening can be reduced, and tissue hyperplasia on the surface of the support after the support is implanted is restrained. Thus, the time window of support implantation treatment can be prolonged, supporting force of the support on tube walls can be increased, and long-dated reappearance can be reduced.

The invention discloses a device and a method for preparation of liquid smoke and co-production of activated carbon by pyrolysis of Chinese hawthorn seeds. The device comprises a feed hopper, a drying chamber, a pyrolyzing furnace, an activating furnace, a gas condensation system, a gas cabinet, a combustor, an activated carbon cooling discharge system and a tail gas treatment device. According to the device, co-production of activated carbon can be realized while the liquid smoke is prepared, comprehensive utilization of the resources is realized, the phenomenon that attention is only paid to production of single product while the economic value of byproducts is neglected is avoided, pollution to the environment is avoided while energy is saved, heat required for the processes of drying, pyrolysis, carbonization, activation and the like of the Chinese hawthorn seeds is supplied by combustible gas of non-condensable gas, activating reaction gas and the like obtained by pyrolysis of the Chinese hawthorn seeds, self-sufficiency of the heat can be realized; according to the system, heat exchange is realized by low temperature air used for combustion of the combustor, vapor required for activation and high temperature activated carbon, each takes what it needs, at the same time, high temperature flue gas is exhausted after passing by the high temperature section and the low temperature section sequentially, gradient utilization of different layers of energy is realized, and the energy utilization efficiency is high.

The present invention relates to a conductive ceramic production technique. Its technical scheme is characterized by that in existent ceramic production process a non-metal conductive material with a certain ratio is added, mixed and made into the ceramic blank plate, the said ceramic blank plate is roasted at high temperature so as to obtain the invented product. After having been roasted at high-temperature on the surface of conductive ceramic blank plate a layer of insulating protective layer is formed, only its intermediate layer is conductive. When it is used, the correspondent two sides of said conductive ceramic plate or correspondent positions of its back surface are grooved and deepened to intermediate conductive layer, then a group or several groups of positive and negative electrodes are embedded so as to make the electrodes be contacted with conductive layer, then the exterior of the electrodes can be insulated, so that said invented conductive ceramic plate can be obtained. It can be extensive used in the fields of heating, roasting, infrared physical therapy and health protection, etc.

The invention relates to a nutritious tonifying dumpling and steamed dumpling stuffing characterized by that, the stuffing is prepared from natural wild vegetables and nourishing meat material or egg material, wherein the natural wild vegetables include shepherd's-purse, purslane, wild amaranth or wild leek, the meat material includes pork, black-bone chicken or donkey's meat, the egg material includes red-core duck's egg or black-bone chicken's egg or quail's egg.

The invention discloses a synthesis method of cyclic pentapeptide. According to the synthesis method, the 'solid-liquid combined production' strategy is adopted, a proper condensation agent is used for a condensation reaction, linear pentapeptides are prepared respectively through a proper process, the cyclization site is located between N-methyl-leucine and leucine, and the efficiency of linear peptide preparation is effectively improved.The proper condensation agent is used for the condensation reaction, racemization in amido bond formation can be effectively reduced, therefore, the purity of a target product can be effectively improved, reaching 99% or above, the requirements of biological activity tests and clinical application can be fully met, and the synthesis method of cyclic pentapeptide has high medical value. The cyclization agent PyBOP is used for a cyclization reaction, the cyclization yield can be effectively increased and reach up to 84.2%.The synthesis method does not require complex purification by column chromatography, redundant amino acids can be simply washed away, the synthesis process is simple, the cost of raw materials is low, reaction conditions are mild, the purity is high, industrialization is easy, and the synthesis method has broad market prospects.

The invention belongs to the fields of drugs and chemical industry, and discloses a quinazoline derivative and a preparation method thereof and an application of the quinazoline derivative used as an anticancer drug. The structural formula of the quinazoline derivative is shown in the specifications, wherein R1 is NH(CH2)mNR5 or NH(CH2)m-Ar; R2 is NHCO(CH2)n NR5, NHCO(CH2)n-Ar, NHCO(CH2)nNH(CH2)nNR5 or NHCO(CH2)nNH(CH2)n-Ar; R3 is F, Cl, Br, I, H, CH3, SO2CH3 or OCH3; R4 is H, NHCO(CH2)nNR5, NHCO(CH2)n-Ar, NHCO(CH2)nNH(CH2)nNR5 or NHCO(CH2)nNH(CH2)n-Ar; -Ar represents various aromatic rings comprising various aromatic heterocyclic rings; m is equal to 2, 3 or 4; n is equal to 1, 2, 3, 4 or 5; and R5 represents alkyl of C1-6, cycloalkyl of C3-6, piperidyl, morpholinyl, piperazinyl or quinoxalinyl. The invention simultaneously discloses the preparation method of the quinazoline derivative and the application of the quinazoline derivative used as the anticancer drug. The experiment proves that the quinazoline derivative of the invention has strong inhibiting effect on telomere DNA expression, has obvious inhibiting effect on various kinds of cancer cell strains, has low toxicity to normal cells, and has wide application prospects in preparation of anticancer drugs.

The invention discloses a 4-substituted-2-arylvinyl quinoline derivative, and a preparation method and an application thereof. A structural formula of the derivative is shown as the formula (I). The formula (I) is shown in the description. In the formula (I), R represents hydrogen, cyclic amino fatty amino, aromatic amino or substituted aromatic amino; and Ar represents substituted carbazole-3-yl, substituted phenyl, phenyl, indole-3-yl or 7-diethylin-2-oxo-1-benzopyran-3-yl. The invention also discloses the preparation method and application of the 4-substituted-2-arylvinyl quinoline derivative. The derivative provided by the invention has the advantages of A[beta] aggregation resistance, activity for resisting oxidation, activity for resisting butylcholinesterase, and metal complexation capacity, and has wide application space in preparing drugs for resisting Alzheimer's diseases.

The invention discloses application of histatin 1 (Hst1) polypeptide in preparation of composite materials for promoting repair of large-area skin defects. The Hst1 polypeptide is found to have the characteristics of promoting cell adhesion and vascularization and inhibiting inflammatory response. The Hst1 polypeptide can be loaded on a variety of biological materials, and can be prepared into dressing, injection, ointment, powder, hydrogel, membranes, sponges, fiber scaffold materials and the like, which can effectively promote the healing of the large-area skin defects, by being compounded with bioactive composite materials, wherein large-area skin defects include traumas, burns, skin ulcer caused by tumor resection or diabetes, and the like. The Hst1 polypeptide provided by the invention is human-derived polypeptide, and has good biocompatibility and biosafety. When being used for the preparation of the composite materials for promoting the repair of the large-area skin defects, theHst1 polypeptide has an important medical value and a good industrialization prospect.

The invention provides an ecological breeding net cage for cocultivation of sea cucumbers and sea urchins and relates to a mariculture net cage technology. The net cage consists of a net cage frame and a net, wherein the net cage frame comprises a buoyance riser, an upper transverse connecting pipe, a lower transverse connecting pipe, a second lower transverse connecting pipe, a bottom anchor, an air pipe and a net cage self-balancing lifting up-and-down mechanism; the net comprises a top net, a bottom net and a side net; sea cucumber growing attachment bases are arranged on the bottom net; a middle supporting net is arranged in the net cage; sea urchin growing attachment bases are arranged on the middle supporting net; each sea urchin growing attachment base is a plate which is rectangular according to overhead view; through holes are formed on the plate; and an inclined flow baffle vertical plate is arranged at one end of the plate. The ecological breeding net cage for cocultivation of the sea cucumbers and the sea urchins has the benefits that the bottom net is used for breeding the sea cucumbers, the middle supporting net is used for breeding the sea urchins, the two marine products are bred in the same net cage, the sea urchins eat pelagic organisms such as algae and the like in water, and the excrement of the sea urchins provides part of food for the sea cucumbers, so that a food chain is formed, the biological organic matter resources in seawater are utilized completely, feed is saved, and the breeding cost is saved; the marine products with high nutritional value, economic value and medical value are obtained; and the breeding benefit of the net cage is greatly increased.

The invention belongs to the field of organic chemical synthesis, and discloses cyclic pentapeptide with a novel structure, as well as a synthetic method and application thereof. The cyclic pentapeptide with the novel structure is cyclo-(N-Me-D-Phe-D-Leu-N-Me-D-Leu-D-Leu-L-Leu), the molecular formula is C35H57N5O5, and the structural formula is shown in the description. The cyclic pentapeptide adopts D-Leu, L-Leu, D-Phe and D-Leu benzyl ester tosilate as raw materials, a tripeptide midbody and a dipeptide midbody are respectively prepared through a proper technology, and a cyclization locus is selected at the amido linkage position adjacent to D and L configurations, so that the cyclization efficiency is effectively increased. The cyclic pentapeptide has the advantages of simple synthetic process, low raw material cost, mild reaction conditions, high purity and easy industrial production, and can fully meet the requirements of medical experiments and clinical application.

The invention discloses a sweet-scented osmanthus cake and a preparation method thereof. The sweet-scented osmanthus cake comprises 75-80 parts of glutinous rice flour, 50-60 parts of water, 8-10 parts of dried sweet-scented osmanthus, 8-12 parts of white granulated sugar, 2-4 parts of honey and 5 parts of black rice flour, and is prepared by uniformly mixing the raw materials and cooking by insulating water through a mould. According to the sweet-scented osmanthus cake, an application range of the sweet-scented osmanthus is enlarged to the making of solid foods, and thus the variety of the cakes is increased, and the special medicinal value of the cake is given; the trophism, the functionality and the diversity of the foods are enriched.

The invention relates to the technical field of medical diagnosis mathematical modeling, and particularly relates to a gas explosion lung injury diagnosis system, a serum marker screening method and alung injury action mechanism research method. According to the invention, a serum metabonomics analysis model is constructed based on LC-MS to obtain a PLS-DA model; and nine specific biomarkers withthe effect of causing gas explosion lung injury are obtained by screening through a metabonomics research method, so that the diagnosis and treatment efficiency of coal mine full-gas explosion injurycrowds is effectively improved, important clinical value and social significance are achieved, and the popularization and application are facilitated. The identification and high-throughput analysisof the action mechanism of the gas explosion lung injury are achieved through a standard substance of BioNovoGene company and the HMDB, massbank, Metlin and KEGG databases, the gas explosion lung injury action mechanism is comprehensively analyzed and evaluated on the overall level, and guidance and predictive research are provided for clarification of metabonomics and the action mechanism of thecoal mine gas explosion lung injury.

The invention discloses a talus prosthesis including a subtalar articular surface and a talonavicular articular surface. The subtalar articular surface and / or the talonavicular articular surface are of porous structures. The talus prosthesis has biological functions, facilitates quick fusion and growth of the prosthesis and a calcaneus and a scaphoid, and thus has great medical value.

A stereoscopic cultivation and breeding method for complementary symbiosis of ganoderma lucidum and wood frogs is characterized by comprising the steps that a good, pure-natural and pollution-free area section is selected, it is ensured that the area section is free of residues, soil is not too alkaline and the area section is a loose sandy soil land section, deep land scarification is performed for 40 centimeters in the first year, leveling is performed, and a ganoderma lucidum and wood frog greenhouse is constructed after six months of sun exposure.Too large area is not allowed, the area of the greenhouse is 200 square meters, the length of the greenhouse is 25 meters, the width of the greenhouse is 8 meters, the height of the greenhouse is 1.9 meters, the area is suitable for a growing environment for the complementary symbiosis of the ganoderma lucidum and the wood frogs, the greenhouse is suitable for conidial powder recovery, the area of the greenhouse is suitable for the wood frogs due to the fact that wood frogs breathe through the skins, the ganoderma lucidum breathes freely, the wood frogs uptake oxygen, the complementary symbiosis is achieved, and the greenhouse is disinfected and sterilized with quick lime water after the greenhouse construction is completed; ganoderma lucidum mycelium in the step 2 is ganoderma lucidum.

The invention relates to a completely degradable covered stent and a covered stent system. The completely degradable covered stent is formed by fusing a degradable bare stent and a covering film, boththe degradable bare stent and the covering film are made of a degradable material, the degradable bare stent is of multi-layer chain-shaped structures which are connected together through a pluralityof S chains distributed in the axial direction, each layer of chain-shaped structures is formed by connecting a plurality of rhombic frames, threading holes are formed in intersections of the rhombicframes, and developing points are arranged at peak positions. The covered stent system comprises the completely degradable covered stent and a delivery system, wherein the delivery system comprises aTIP end, a balloon, a protective sheath, a far-end tube, an inner tube and a near-end tube, the covering film stent is loaded on the balloon, one side facing the near-end is connected with a hanging-corner stent on the far-end tube through a hanging corner, and the protective sheath sleeves the covering film stent. An interventional implantation-free instrument concept is adopted, the forming iseasy, the operation implantation into a human body is convenient, no residual foreign matter is generated, the treatment of a patient is facilitated to the most degree, the medical value is very high,and the operation is safe and convenient.