The invention relates to a cultivation method of plum in Karst rock-desertification areas. The varieties of the cultivated plum are 'Nanhua plum', 'Sanhua plum' and 'Shuanghua plum'. The cultivation method includes the steps of land preparation, field planting, fertilizer and water management, pruning, field management and pest control. The cultivated plum trees are strong in tree vigor, hard in branches, long in life and high in fruiting rate, the plum fruit has rich nutritional value, contains sugar, microprotein, fat, carotene, vitamins B1, B2 and C, niacin, calcium, phosphorus, iron, asparagine, glutamine, serine, glycine, proline, threonine, alanine and the like and can be processed into good-taste dried plum, honey plum slices, sugar preserved plum and the like beside fresh eating, the plum is suitable for being planted in the rock-desertification areas under the condition of poor soil for water and soil conservation, ecological environment is restored for poverty-stricken areas, and income is increased for mass peasants.