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Biodegradable cardia support

A biodegradable cardia technology, applied in stents, drug devices, medical science, etc., can solve the problems of increasing the risk of bleeding and esophageal perforation, complete repair of cardia tissue, and reducing the treatment effect, so as to reduce scar tissue hyperplasia and hypertrophy, Effects of inhibiting fibroblast proliferation and prolonging the time window

Inactive Publication Date: 2013-03-20
SHANGHAI TENTH PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in general, in order to avoid difficulty in taking out the stent surrounded by hyperplastic tissue, the temporary metal cardia stent must be taken out within 1 week after implantation, otherwise it will make it difficult to take out the stent and increase the risk of complications such as bleeding and esophageal perforation. If it is removed within 1 week, the cardia tissue around the stent cannot be completely repaired, which reduces the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Biodegradable cardiac stent structure:

[0037] Such as figure 1 As shown, a biodegradable cardiac stent of the present invention includes a biodegradable stent skeleton made of biodegradable polymer material filaments, wherein preferably a polymer material with a diameter of 0.4-0.6mm filament. The biodegradable stent skeleton includes a drum-shaped positioning port 2 at the upper end, a trumpet-shaped positioning port 3 at the lower end, and a support network pipe 1 connecting the drum-shaped positioning port 2 and the trumpet-shaped positioning port 3; this structure makes After the stent is released, the drum-shaped structure at the upper end, together with the large-diameter support network tube, can well prevent the esophageal peristaltic wave from pushing the stent to shift, which is conducive to the positioning of the biodegradable stent skeleton. The biodegradable cardia stent also includes a slow-release drug layer 6; and the slow-release drug layer 6 is c...

Embodiment 2

[0050] Such as figure 2 As shown, the difference between this embodiment 2 and embodiment 1 is that, at the junction of the drum-shaped positioning opening 2 and the support network pipe 1, and the junction of the trumpet-shaped positioning opening 3 and the support network pipe 1 are respectively equipped with The anti-reflux flaps 42 and 41 form a double-layer anti-reflux cardia stent. And, if image 3 As shown, the vertical projections of the crack between the two anti-reflux flaps 41 and 42 do not coincide. This structure can effectively improve the anti-reflux effect while maintaining good ventilation performance.

Embodiment 3

[0052] Such as Figure 4 As shown, in a biodegradable cardia stent of the present invention, a recovery line 5 capable of concentrically contracting the drum-shaped positioning opening is installed on the opening edge of the drum-shaped positioning opening 2 at the upper end of the biodegradable stent skeleton; When clinically needed, the recovery line 5 can be pulled to make the drum-shaped positioning opening 2 concentrically contract, and then drive the entire cardia stent to concentrically contract, so that it is convenient to adjust the position of the cardia stent or take the whole stent out of the body when necessary.

[0053] Example 3

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Abstract

The invention provides a biodegradable cardia support. The biodegradable cardia support comprises a biodegradable support framework which is formed by weave of biodegradable high polymer material filaments, and a layer of controlled-release drug layer is coated on the surface of the biodegradable support framework. The support framework and drug carriers are made of high polymer biodegradable materials and can fully and automatically degradate after time window treatment is finished, and therefore the trouble of taking out the support is avoided. In addition, the controlled-release drug layer can release anti-inflammatory drugs stably through drug controlled-release technology, and therefore fibroblast hyperplasia caused by esophagus repair reaction can be effectively restrained, subsequent scar tissue hyperplasia and thickening can be reduced, and tissue hyperplasia on the surface of the support after the support is implanted is restrained. Thus, the time window of support implantation treatment can be prolonged, supporting force of the support on tube walls can be increased, and long-dated reappearance can be reduced.

Description

Technical field [0001] The present invention involves a kind of medical bracket, especially a cardiac stent that can be degraded by self -degradable therapeutic cardia. Background technique [0002] The benign stenosis lesions of the cardia are commonly characterized by the common esophageal dysfunctional diseases. It is mainly characterized by lack of peristalsis and esophageal sphinceal sphinctor (LES).Its pathological changes are mainly due to the reduction of the neurosurable neurons in the LES muscle, causing long -term relaxation dysfunctional dysfunction, and the muscle layer gradually becomes thick.The current minimally invasive treatment technologies mainly include the split botulinum and X -ray or endoscopic guidance of the acupunctured solution surgery of the cardia muscle loosening surgery of the chest, the laparoscopy, the endoscopic cardia muscle injectionScholar formation and so on. [0003] However, because the benign cardia stenosis lesions are different from gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61M31/00A61L31/06A61L31/16
Inventor 程英升朱悦琦贾梦虹常江崔文国
Owner SHANGHAI TENTH PEOPLES HOSPITAL
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