The invention provides a tablet for assisting to reduce blood glucose and a preparation method. The tablet for assisting to reduce blood glucose comprises the following main raw materials in parts by weight: 100-130 parts of folium mori extract, 100-130 parts of bitter gourd extract, 30-60 parts of American ginseng extract, 50-100 parts of pseudo-ginseng extract, 50-100 parts of lucid ganoderma extract, 50-100 parts of astragalus membranaceus extract, and 8-15 parts of chromium-enriched yeast. The tablet for assisting to reduce blood glucose further comprises the following auxiliary materials in parts by weight: 150-200 parts of dextrin, 5-10 parts of magnesium stearate, and 10-15 parts of coating powder. According to the invention, the blood glucose of a diabetic patient is reduced by utilizing the complementarily synergistic effect of various components; and the tablet disclosed by the invention is also capable of reducing blood pressure, blood fat and blood viscosity, improving microcirculation to prevent peripheral neuropathy, improving ischemic and anaerobic states of brains and various tissues, increasing organism antioxygen ability, improving retinopathy, and increasing organism immunity.