Pharmaceutical composition and application thereof
A composition and drug technology applied in the field of medicine to achieve the effects of reducing infiltration, increasing conception rate, and reducing hypertrophy
Active Publication Date: 2022-08-05
CHINA PHARM UNIV
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- Description
- Claims
- Application Information
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Problems solved by technology
At present, the main drugs for the treatment of primary dysmenorrhea are non-steroidal anti-inflammatory drugs, but their inefficiency is 20%-30%, so there is an urgent need to find a low-risk, effective drug to relieve dysmenorrhea
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0036] A pharmaceutical composition is composed of 1,6-diphosphate fructose trisodium salt and nicotinamide mononucleotide NMN; the moles of 1,6-diphosphate fructose trisodium salt FDP and nicotinamide mononucleotide NMN are The ratio is 1:1.
Embodiment 2
[0038] A pharmaceutical composition is composed of 1,6-diphosphate fructose trisodium salt and nicotinamide mononucleotide NMN; the moles of 1,6-diphosphate fructose trisodium salt FDP and nicotinamide mononucleotide NMN are The ratio is 1:2.
Embodiment 3
[0040] A pharmaceutical composition is composed of 1,6-diphosphate fructose trisodium salt and nicotinamide mononucleotide NMN; the moles of 1,6-diphosphate fructose trisodium salt FDP and nicotinamide mononucleotide NMN are The ratio is 1:3.
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The invention discloses a pharmaceutical composition and application thereof, and the pharmaceutical composition is composed of 1, 6-fructose diphosphate (FDP) or a pharmaceutically acceptable salt thereof, and nicotinamide mononucleotide NMN / nicotinamide adenine dinucleotide NAD + or a pharmaceutically acceptable salt thereof. The invention also discloses application of the compound in preparation of medicines for preventing and / or treating primary dysmenorrhea and infertility. The invention discloses an action mechanism of FDP and NMN / NAD < + > combined administration in treating a mouse primary dysmenorrhea model, and finds that the FDP and NMN / NAD < + > combined administration has a better curative effect than FDP or NMN / NAD < + > independent administration, and can obviously reduce the writhing reaction frequency of a female mouse, increase the incubation period of the writhing reaction, reduce the gene expression level of COX-2 and PGF2alpha in uterine tissues, increase the gene expression level of PGE2, and improve the mouse primary dysmenorrhea treatment effect. Infiltration of inflammatory cells is reduced, and uterine tissue edema and inflammatory pathology degree are improved; in addition, combined administration of FDP and NMN / NAD + can significantly increase the pregnancy rate of female mice compared with independent administration of FDP or NMN / NAD +.
Description
technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition and use thereof. The pharmaceutical composition is composed of fructose 1,6-diphosphate (FDP) or a pharmaceutically acceptable salt thereof and nicotinamide mononucleotide NMN / nicotinamide adenine dinucleotide NAD + Or its pharmaceutically acceptable salt composition; and its preparation in the prevention and / or treatment of primary dysmenorrhea, infertility medicine application. Background technique [0002] Primary dysmenorrhea (PD) refers to the cramping pain in the lower abdomen of women during menstruation without obvious pelvic organic lesions, accompanied by low back and leg pain, diarrhea, nervousness, fatigue, loss of appetite, and nausea. Symptoms such as vomiting. At present, the drugs for primary dysmenorrhea are mainly non-steroidal anti-inflammatory drugs, but their inefficiency is 20%-30%. Therefore, there is an urgent need to find a l...
Claims
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IPC IPC(8): A61K31/706A61K31/7084A61K31/7004A61P15/00A61P29/00A61P15/08
CPCA61K31/706A61K31/7084A61K31/7004A61P15/00A61P29/00A61P15/08A61K2300/00Y02A50/30
Inventor 庞涛魏大厦黄丽华管昕郑月钦
Owner CHINA PHARM UNIV
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