31 results about "Neutral Amino Acids" patented technology

The invention discloses tranexamic acid-polypeptide conjugate as well as a preparation method and application thereof, and belongs to the technical field of biology. The invention relates to a tranexamic acid-polypeptide conjugate or a salt thereof. The structure of the tranexamic acid-polypeptide conjugate is as shown in the following formula (I): TXA-Xaa1-L-phenylalanyl-D-arginyl-L-tryptophanyl-Xaa2-NH2 (I), wherein TXA-Xaa1-L-phenylalanyl-D-arginyl-L-tryptophanyl-Xaa2-NH2 (I) is shown in the description; wherein TXA is 4-(aminomethyl) cyclohexane carbonyl, and TXA is 4-(aminomethyl) cyclohexane carbonyl; xaa1 is a chemical bond, a neutral amino acid residue or a hydrophilic linker; xaa2 is a chemical bond, a neutral amino acid residue or a hydrophilic linker. The tranexamic acid-polypeptide conjugate or the salt thereof disclosed by the invention can simultaneously block two key signal channels for melanogenesis to achieve a synergistic effect of '1 + 1gt, 2', and further improve the inhibition effect on melanogenesis.

An aqueous solution composition having a pH in the range of 4.0 to 8.5, comprising: an antibody construct comprising an Fc domain; optionally, one or more buffering agents which are a substance having at least one ionizable group, have a pKa in the range of 3.0 to 9.5, and have a pKa within 2 pH units of the pH of the composition; optionally, one or more neutral amino acids; and an uncharged tension regulator; wherein the total concentration of the buffer in the composition is 0-5 mM; and wherein the composition has a total ionic strength of less than 20 mM, excluding the contribution of engineered protein constructs.

The invention provides a copolymer polypeptide as well as a pharmaceutical composition and application thereof. The copolymer polypeptide is formed by linear random copolymerization of a first monomer, a second monomer and a third monomer; the first monomer is selected from any one of alkaline amino acid and derivatives thereof; the second monomer is selected from any one of acidic amino acid and derivatives thereof; the third monomer is selected from any one of neutral amino acid and derivatives thereof. The copolymer polypeptide and the pharmaceutical composition thereof provided by the invention can effectively relieve hyperkeratosis caused by psoriasis, relieve inflammatory enteritis and effectively inhibit tumor growth.

An aqueous solution composition of pH in the range 4.0-8.5 comprising:an antibody construct comprising an Fc domain;optionally one or more buffers being substances having at least one ionisable group with a pKa in the range 3.0 to 9.5 and which pKa is within 2 pH units of the pH of the composition;optionally one or more neutral amino acids; andan uncharged tonicity modifier;wherein the buffers are present in the composition at a total concentration of 0-5 mM; andwherein the total ionic strength of the composition excluding the contribution of the engineered protein construct is less than 20 mM.

The invention discloses a gardenia blue pigment as well as a preparation method and application thereof, and the preparation method comprises the following steps: adding neutral amino acid or arginine with the molecular weight greater than 130 into a phosphate solution containing genipin, and reacting under the condition that the pH is 4-10 to obtain a reaction solution; the reaction solution is sequentially eluted through a macroporous resin chromatographic column, water and 30%-80% ethyl alcohol, a developed ethyl alcohol eluent is collected, vacuum concentration and drying are conducted, and the gardenia blue pigment is obtained. According to the method, the phosphate solution is adopted as a catalyst to catalyze the genipin to react with the preferable arginine and the specific neutral amino acid to synthesize the high-tone gardenia blue pigment, meanwhile, the reaction temperature and time are regulated and controlled, the quality of the gardenia blue pigment is improved, the characteristic lambda max of the visible spectrum of the gardenia blue pigment is not lower than 602 nm, and A610 / A585 is not lower than 1.0; the prepared high-tone gardenia blue pigment is safe and non-toxic, and can be applied as a coloring agent in the fields of food, cosmetics and pharmaceuticals.

This application discloses an HIV antigen comprising the gp41 protein; said gp41 protein contains at least one amino acid residue selected from the following: T at position 85; K at position 98; a basic amino acid R or K at position 109; a neutral amino acid L or I at position 111; a basic amino acid K or R at position 132; N at position 133; and an acidic amino acid D or E at position 139. The HIV antigen of this application has the advantages of high specificity and high sensitivity.

The object of the present invention is to provide an absorption enhancer capable of introducing high-molecular weight compounds into cells.The object can be solved by a composition of the present invention comprising a polymer compound having a group represented by the following general formula (1) or the following general formula (2) at a side chain, and a compound to be administered with a molecular weight of 1,000 to 1,200,000.wherein X1 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X2 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X3 is a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms or a benzyloxy group, a is an integer of 0 to 50, and * denotes a bonding site.wherein X4 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X5 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X6 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group or an oxycarbonyl group, b is an integer of 0 to 50, and * denotes a bonding site.

The present invention provides a cyclic peptide represented by formula (I)[wherein A is selected from the ring-forming groups A1 to A5; Xaa1 is a residue of an aromatic amino acid; Xaa2 is a residue of an aromatic amino acid, a basic amino acid, or an aliphatic amino acid; Xaa3 and Xaa8 each have a structure independently selected from a residue of an amino acid represented by formula (III) or (III′) in which thiol groups of Xaa3 and Xaa8 form a bond; Xaa4 is a residue of a neutral amino acid; Xaa5 is a residue of a basic amino acid; Xaa6 is a residue of a neutral amino acid or an acidic amino acid; Xaa7 is a residue of an aromatic amino acid; Xaa9 is a residue of an aromatic amino acid, an aliphatic amino acid, or a basic amino acid; Xaa10 is a residue of an aromatic amino acid; and Xaa11 is a residue of an aliphatic amino acid], or a pharmaceutically acceptable salt thereof.

The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of PSMA-expressing cancers, especially prostate cancer, and metastases thereof. In particular, the present invention relates to a PSMA binding ligand or a pharmaceutically acceptable salt or solvate thereof as well as to the use of said PSMA binding ligand, the PSMA binding ligand comprising a PSMA binding motif Q and a chelator residue A linked via at least one linker LAQ comprising at least one, optionally N-alkylated, neutral amino acid Xi.

The present invention relates to the technical field of scale and corrosion inhibitors, and discloses a preparation process of a neutral amino acid-based scale and corrosion inhibitor. The present invention reacts 3,5-dihydroxybenzaldehyde, taurine, epichlorohydrin, and N,N,N',N'-tetramethylethylenediamine to obtain a scale and corrosion inhibitor. The sulfonate and hydroxyl groups contained in the scale and corrosion inhibitor form stable chelates with barium ions and strontium ions, which can prevent the barium ions and strontium ions from combining with anions such as sulfate to form insoluble precipitates such as barium sulfate and strontium sulfate, thereby achieving excellent scale inhibition performance. The scale and corrosion inhibitor contains multiple active coordination centers of quaternary ammonium salt cations, sulfonate, and hydroxyl groups, which interact with the surface of a steel sheet to form a tight and firm protective film on the surface, preventing corrosive media such as hydrochloric acid from contacting the steel sheet, achieving excellent anti-corrosion and corrosion inhibition performance at high temperatures, and has good practical applications in oil field water injection and oil production.

The invention relates to storage stable compositions of dalbavancin. In particular, the storage stable composition is an aqueous liquid solution comprising: dalbavancin or a pharmaceutically acceptable salt thereof; a neutral amino acid or a pharmaceutically acceptable salt thereof; and a non-ionic surfactant, wherein the pH of the composition is in the range of about 3.0 to about 7.0.

The invention relates to the technical field of cleaning agents, and discloses a pH-neutral amino acid surfactant type water cup cleaning agent which comprises the following components in percentage by weight: 10-25% of an amino acid surfactant with the purity of greater than or equal to 98%, 1-5% of a sodium citrate-citric acid buffer pair and 65-85% of deionized water. The amino acid surfactant is selected from at least one of sodium cocoyl glutamate and sodium lauroyl sarcosinate; the weight ratio of the sodium citrate-citric acid buffer pair to the amino acid surfactant is 1: (2-5); the pH value of the cleaning agent is 6.5-7.5, and the contact corrosion rate of the cleaning agent to a glass coating layer and a ceramic glaze surface is smaller than or equal to 0.01 mm / year. By selecting food-grade-sourced active matters, stubborn tea residues and coffee stains can be thoroughly disintegrated, meanwhile, a precise coating, a ceramic glaze surface or a plastic material on the inner wall of the cup is prevented from being damaged, the general cognition that a traditional mild product is insufficient in dirt-removing power is changed, the unification of deep cleaning and great maintenance is realized, and the service life of the cup is prolonged. And the use safety is ensured.

An aqueous composition having a pH in the range of 4.0–8.5, comprising: an antibody construct containing an Fc domain; optionally, one or more buffers having at least one ionizable group and a pK value in the range of 3.0 to 9.5. a And its PK a Within 2 pH units of the pH of the composition; optionally, one or more neutral amino acids; and an uncharged tension modifier; wherein the total concentration of the buffer in the composition is 0-5 mM; and wherein the total ionic strength of the composition is less than 20 mM, excluding the contribution of engineered protein constructs.

To provide methods and means for improved and / or alternative technologies for producing biological therapeutics in the form of mixtures or bispecific approaches for targeting multiple disease-modifying molecules.SOLUTION: A method for producing a heterodimeric Ig-like molecule from a single host cell is provided, wherein the Ig-like molecule comprises two CH3 domains that are capable of forming an interface, the method comprising providing in the cell a. a first nucleic acid molecule encoding a first CH3 domain-comprising polypeptide chain, b. a second nucleic acid molecule encoding a second CH3 domain-comprising polypeptide chain, the first CH3 domain-comprising polypeptide chain comprising at least one substitution of a neutral amino acid residue with a positively charged amino acid residue, the second CH3 domain-comprising polypeptide chain comprising at least one substitution of a neutral amino acid residue with a negatively charged amino acid residue, the method further comprising culturing the host cell, expressing the two nucleic acid molecules, and harvesting the heterodimeric Ig-like molecule from the culture.SELECTED DRAWING: None

This invention provides a pentapeptide-derived peptide YS for anti-skin aging and its applications, relating to the field of biochemistry. The pentapeptide-derived peptide YS comprises KTTKS and an N-terminal modified peptide. The N-terminal modified peptide consists of basic amino acids and uncharged amino acids arranged alternately, with the number of basic amino acids not less than 50%. The uncharged amino acids are selected from neutral amino acids and / or polar neutral amino acids. The number of uncharged amino acids arranged consecutively does not exceed three. The N-terminal amino acid of the N-terminal modified peptide is tyrosine, and the C-terminus consists of three consecutive uncharged amino acids. This invention modifies the N-terminus of the pentapeptide KTTKS with a specific structure of amphiphilic peptide, unexpectedly obtaining a pentapeptide-derived peptide YS with good water solubility and strong skin penetration, exhibiting significant anti-skin aging effects without the need for additional chemical penetration enhancers, making it safer and more effective.

The invention discloses a mutant of helicase Dda, a preparation method of the mutant and application of the mutant in sequencing. The mutant is one or more mutations selected from the following mutations on an amino acid sequence shown as SEQ ID NO: 4: (1) replacing positively charged amino acid in the amino acid sequence with neutral amino acid; (2) replacing the amino acid with negative electricity in the amino acid sequence with neutral amino acid; (3) truncating amino acid in an N-terminal region in the amino acid sequence or substituting the amino acid with short-side-chain neutral amino acid; and (4) substituting the amino acid with relatively large side chain amino acid steric hindrance in the amino acid sequence with short side chain amino acid. According to the mutant, the sequencing capability is greatly improved, and further promotion of nanopore sequencing work is facilitated.

Phenylalanine-based inhibitors of the Large Amino Acid Transporter 1 (LAT1) are disclosed. The compounds are useful in modulating the transcellular transport of substrates of LAT1 such as large neutral amino acids. The compounds are useful in immunomodulation therapies.

Phenylalanine-based inhibitors of the Large Amino Acid Transporter 1 (LAT1) are disclosed. The compounds are useful in modulating the transcellular transport of substrates of LAT1 such as large neutral amino acids. The compounds are useful in immunomodulation therapies.

A nano-drug delivery system modified with a phenolic acid or dipeptide for increasing the oral absorbability and bioavailability, which system is prepared from a nanocarrier and an auxiliary material. The nanocarrier is modified with a phenolic acid or dipeptide on the surface thereof as a ligand, and actively targets a receptor on the surface of intestinal epithelial cells, wherein the phenolic acid ligand is a hydroxycinnamic acid derivative, and the dipeptide ligand is a combination of a cationic amino acid and a neutral amino acid. An oral nano-drug delivery system is constructed by using a phenolic acid or dipeptide, which is an essential nutrient for a human body, as a ligand to mimic the absorption pathway of phenolic acid or dipeptide, which system significantly enhances the oral absorption efficiency of a drug by using the natural highly-efficient absorption capacity of the small intestine for nutrients.

The invention relates to the technical field of waste paper pulp treatment, and discloses a method for improving the performance of waste paper pulp, which comprises the following steps: S1, paper pulp pretreatment: S2, paper pulp impurity removal: putting to-be-treated pulp into screening equipment, and collecting to obtain undersize pulp; s3, extruding and dispersing: putting the undersize material into an extruding machine; s4, ultrasonic treatment: readjusting the concentration of the extruded slurry, and then putting the slurry into an ultrasonic processor to obtain pretreated slurry; s5, preparing a compound liquid: mixing alkaline amino acid, acidic amino acid and neutral amino acid according to a mass ratio, adding ionized water, and stirring to obtain the amino acid compound liquid; s6, modification treatment: mixing and stirring the pretreated slurry subjected to ultrasonic treatment and the amino acid compound liquid in S5; and S7, washing and drying: washing the mixed pulp after the reaction in the step S6 with deionized water to obtain the high-performance paper pulp. The method has the following advantages and effects: through physical and chemical combination and compounding treatment of multiple amino acids, synchronous optimization of whiteness and strength is realized.

The present invention relates to a cleaning agent composition containing (A) one or more substances selected from the group consisting of N-acyl alanine having an acyl group having 8-22 carbon atoms and salts thereof, (B) one or more substances selected from the group consisting of fatty acids having 8-22 carbon atoms and salts thereof, and (C) one or more substances selected from the group consisting of alanine and salts thereof, the content ratio of component (A), component (B), and component (C) [(A): (B): (C)] being 100: 45-245: 10-150 by weight ratio. According to the present invention, it is possible to provide a detergent composition containing an N-acyl neutral amino acid or a salt thereof, the detergent composition having excellent foamability, foam quality, and feeling of use, imparting a good moist feeling to the skin and hair after washing and drying, and further improving the dry feeling after washing.

The present invention addresses the problem of providing an oil-in-water emulsion cosmetic composition having improved emulsion stability in a high-temperature environment. [Solution] An oil-in-water type emulsion cosmetic composition comprising the following components (A) to (E) or comprising the following components (A) to (E): (A) a neutral amino acid or a peptide thereof, (B) particles surface-treated with a nonionic hydrophobic treatment agent, (C) water, (D) an oil component, and (E) an emulsifier, the content of component (A) being more than 0.1 mass%.

The invention discloses a phenolic acid or dipeptide modified nano drug delivery system for increasing oral absorption availability, which is characterized in that the system is prepared from a nano carrier and auxiliary materials, the nano carrier is modified on the surface of the nano carrier by taking phenolic acid or dipeptide as a ligand and actively targets intestinal mucosa epithelial cell surface receptors; the phenolic acid ligand is a hydroxyl cinnamic acid derivative; the dipeptide ligand is a combination of cationic amino acid and neutral amino acid. According to the invention, a nutrient substance phenolic acid or dipeptide required by a human body is creatively adopted as a ligand to construct an oral nano drug delivery system simulating a phenolic acid or dipeptide absorption pathway, and the oral absorption efficiency of the drug is remarkably improved by utilizing the natural and efficient absorption capability of small intestines to nutrient substances.

Phenylalanine-based inhibitors of the Large Amino Acid Transporter 1 (LAT1) are disclosed. The compounds are useful in modulating the transcellular transport of substrates of LAT1 such as large neutral amino acids. The compounds are useful in immunomodulation therapies.

The present invention relates to the field of genetic engineering, and in particular to a proximity marker enzyme mutant and its application. The proximity marker enzyme mutant uses ProtA-Turbo as the starting sequence, and mutates one or more sites among K71, K240, K335, K345 and K351 to non-polar hydrophobic amino acids, polar neutral amino acids, acidic amino acids, basic amino acids or non-natural amino acids. The proximity marker enzyme mutant of the present invention overcomes the influence of self-biotinylation on its proximity marker activity, and can continuously and stably mark the proximity protein group of the target protein on the fixed cell, significantly improving the sensitivity of identifying the proximity interacting proteins of the target protein.

Phenylalanine-based inhibitors of the Large Amino Acid Transporter 1 (LAT1) are disclosed. The compounds are useful in modulating the transcellular transport of substrates of LAT1 such as large neutral amino acids. The compounds are useful in immunomodulation therapies.

An aqueous solution composition having a pH in the range of 4.0 to 8.5, comprising: an antibody construct comprising an Fc domain; optionally, one or more buffering agents which are a substance having at least one ionizable group, have a pKa in the range of 3.0 to 9.5, and have a pKa within 2 pH units of the pH of the composition; optionally, one or more neutral amino acids; and an uncharged tension regulator; wherein the total concentration of the buffer in the composition is 0-5 mM; and wherein the composition has a total ionic strength of less than 20 mM, excluding the contribution of engineered protein constructs.

The invention provides a method for repairing cadmium-polluted soil through folium artemisiae argyi and application, and the method for repairing the cadmium-polluted soil through the folium artemisiae argyi is characterized by comprising the following steps that S1, the folium artemisiae argyi is planted in the cadmium-polluted soil; s2, in the vigorous vegetative growth period of the folium artemisiae argyi, a first amino acid composition is applied to the soil, and a zinc-containing solution is sprayed to leaves of the folium artemisiae argyi; s3, in the growth stable period of the folium artemisiae argyi, a second amino acid composition is applied to the soil; wherein the first amino acid composition and the second amino acid composition both contain acidic amino acid and neutral amino acid, and the proportion of the acidic amino acid in the first amino acid composition is smaller than that of the acidic amino acid in the second amino acid composition.

To provide an oil-in-water emulsified cosmetic composition in which emulsification stability under high-temperature environments is enhanced.SOLUTION: An oil-in-water emulsified cosmetic composition comprising or consisting of the following components (A) to (E): (A) a neutral amino acid or a peptide thereof, (B) particles whose surface is treated with a nonionic hydrophobic treatment agent, (C) water, (D) oil component, and (E) emulsifier, where the content of the component (A) is more than 0.1 mass%.SELECTED DRAWING: None