9 results about "Neutral Amino Acids" patented technology

An aqueous solution composition having a pH in the range of 4.0 to 8.5, comprising: an antibody construct comprising an Fc domain; optionally, one or more buffering agents which are a substance having at least one ionizable group, have a pKa in the range of 3.0 to 9.5, and have a pKa within 2 pH units of the pH of the composition; optionally, one or more neutral amino acids; and an uncharged tension regulator; wherein the total concentration of the buffer in the composition is 0-5 mM; and wherein the composition has a total ionic strength of less than 20 mM, excluding the contribution of engineered protein constructs.

An aqueous solution composition of pH in the range 4.0-8.5 comprising:an antibody construct comprising an Fc domain;optionally one or more buffers being substances having at least one ionisable group with a pKa in the range 3.0 to 9.5 and which pKa is within 2 pH units of the pH of the composition;optionally one or more neutral amino acids; andan uncharged tonicity modifier;wherein the buffers are present in the composition at a total concentration of 0-5 mM; andwherein the total ionic strength of the composition excluding the contribution of the engineered protein construct is less than 20 mM.

The invention discloses a gardenia blue pigment as well as a preparation method and application thereof, and the preparation method comprises the following steps: adding neutral amino acid or arginine with the molecular weight greater than 130 into a phosphate solution containing genipin, and reacting under the condition that the pH is 4-10 to obtain a reaction solution; the reaction solution is sequentially eluted through a macroporous resin chromatographic column, water and 30%-80% ethyl alcohol, a developed ethyl alcohol eluent is collected, vacuum concentration and drying are conducted, and the gardenia blue pigment is obtained. According to the method, the phosphate solution is adopted as a catalyst to catalyze the genipin to react with the preferable arginine and the specific neutral amino acid to synthesize the high-tone gardenia blue pigment, meanwhile, the reaction temperature and time are regulated and controlled, the quality of the gardenia blue pigment is improved, the characteristic lambda max of the visible spectrum of the gardenia blue pigment is not lower than 602 nm, and A610 / A585 is not lower than 1.0; the prepared high-tone gardenia blue pigment is safe and non-toxic, and can be applied as a coloring agent in the fields of food, cosmetics and pharmaceuticals.

This application discloses an HIV antigen comprising the gp41 protein; said gp41 protein contains at least one amino acid residue selected from the following: T at position 85; K at position 98; a basic amino acid R or K at position 109; a neutral amino acid L or I at position 111; a basic amino acid K or R at position 132; N at position 133; and an acidic amino acid D or E at position 139. The HIV antigen of this application has the advantages of high specificity and high sensitivity.

This invention provides a pentapeptide-derived peptide YS for anti-skin aging and its applications, relating to the field of biochemistry. The pentapeptide-derived peptide YS comprises KTTKS and an N-terminal modified peptide. The N-terminal modified peptide consists of basic amino acids and uncharged amino acids arranged alternately, with the number of basic amino acids not less than 50%. The uncharged amino acids are selected from neutral amino acids and / or polar neutral amino acids. The number of uncharged amino acids arranged consecutively does not exceed three. The N-terminal amino acid of the N-terminal modified peptide is tyrosine, and the C-terminus consists of three consecutive uncharged amino acids. This invention modifies the N-terminus of the pentapeptide KTTKS with a specific structure of amphiphilic peptide, unexpectedly obtaining a pentapeptide-derived peptide YS with good water solubility and strong skin penetration, exhibiting significant anti-skin aging effects without the need for additional chemical penetration enhancers, making it safer and more effective.

A nano-drug delivery system modified with a phenolic acid or dipeptide for increasing the oral absorbability and bioavailability, which system is prepared from a nanocarrier and an auxiliary material. The nanocarrier is modified with a phenolic acid or dipeptide on the surface thereof as a ligand, and actively targets a receptor on the surface of intestinal epithelial cells, wherein the phenolic acid ligand is a hydroxycinnamic acid derivative, and the dipeptide ligand is a combination of a cationic amino acid and a neutral amino acid. An oral nano-drug delivery system is constructed by using a phenolic acid or dipeptide, which is an essential nutrient for a human body, as a ligand to mimic the absorption pathway of phenolic acid or dipeptide, which system significantly enhances the oral absorption efficiency of a drug by using the natural highly-efficient absorption capacity of the small intestine for nutrients.

The present invention relates to a cleaning agent composition containing (A) one or more substances selected from the group consisting of N-acyl alanine having an acyl group having 8-22 carbon atoms and salts thereof, (B) one or more substances selected from the group consisting of fatty acids having 8-22 carbon atoms and salts thereof, and (C) one or more substances selected from the group consisting of alanine and salts thereof, the content ratio of component (A), component (B), and component (C) [(A): (B): (C)] being 100: 45-245: 10-150 by weight ratio. According to the present invention, it is possible to provide a detergent composition containing an N-acyl neutral amino acid or a salt thereof, the detergent composition having excellent foamability, foam quality, and feeling of use, imparting a good moist feeling to the skin and hair after washing and drying, and further improving the dry feeling after washing.

An aqueous solution composition having a pH in the range of 4.0 to 8.5, comprising: an antibody construct comprising an Fc domain; optionally, one or more buffering agents which are a substance having at least one ionizable group, have a pKa in the range of 3.0 to 9.5, and have a pKa within 2 pH units of the pH of the composition; optionally, one or more neutral amino acids; and an uncharged tension regulator; wherein the total concentration of the buffer in the composition is 0-5 mM; and wherein the composition has a total ionic strength of less than 20 mM, excluding the contribution of engineered protein constructs.