The present invention relates to one kind of angiogenesis inhibiting fusion protein and its use. The fusion proteins of the present invention are produced through fusing FLT-1 segment, KDR segment and immunoglobulin Fc segment, and are named as FP1, FP2, FP3, FP4, FP5 and FP6. The amino acid sequences FLT-1 D2, FLT-1 D4, KDR, D1, KDR D3, KDR D4 and FP3 in the immunoglobulin-like area of FLT-1 and KDR are shown in the sequence lists 1-6, and FP3 coded DNA sequence is shown in the sequence list 7.