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Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallyglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.

Provided is a fully automated web service with location based services generally involved in transmission of situational location dependent information to automatically located mobile receiving data processing systems. The web service communicates with a receiving data processing system in a manner by delivering information to the device when appropriate without the device requesting it at the time of delivery. There are varieties of configurations made by different user types of the web service for configuring information to be delivered, and for receiving the information. The web service maximizes anonymity of users, provides granular privacy control with a default of complete privacy, and supports user configurable privileges and features for desired web service behavior and interoperability. The web service is fully automated to eliminate human resources required to operate services. Integrated with the web service are enhanced location based services providing map solutions, alerts, sharing of novel services between users, and complete user control for managing heterogeneous device interoperability through the web service.

The present invention relates to a new imidazole derivative, a method for preparing the derivative, and an organic electronic device using the derivative. The imidazole derivative according to the invention can perform functions of hole injection, hole transportation, electron injection, electron transportation, and / or light emission in an organic electronic device including an organic light-emitting device. The organic electronic device according to the invention exhibits excellent characteristics in terms of efficiency, drive voltage and stability.

A system and method for generating a list is provided. The system includes a seed item input subsystem, an item identifying subsystem, a descriptive metadata similarity determining subsystem and a list generating subsystem that builds a list based, at least in part, on similarity processing performed on seed item descriptive metadata and user item descriptive metadata and user selected thresholds applied to such similarity processing. The method includes inexact matching between identifying metadata associated with new user items and identifying metadata stored in a reference metadata database. The method further includes subjecting candidate user items to similarity processing, where the degree to which the candidate user items are similar to the seed item is determined, and placing user items in a list of items based on user selected preferences for (dis)similarity between items in the list and the seed item.

An image sensor for capturing a color image is disclosed having a two-dimensional array having first and second groups of pixels wherein pixels from the first group of pixels have narrower spectral photoresponses than pixels from the second group of pixels and wherein the first group of pixels has individual pixels that have spectral photoresponses that correspond to a set of at least two colors. Further, the placement of the first and second groups of pixels defines a pattern that has a minimal repeating unit including at least twelve pixels. The minimal repeating unit has a plurality of cells wherein each cell has at least two pixels representing a specific color selected from the first group of pixels and a plurality of pixels selected from the second group of pixels arranged to permit the reproduction of a captured color image under different lighting conditions.

Nano-composite materials with enhanced thermal performance that can be used for thermal management in a wide range of applications, including heat sinks, device packaging, semiconductor device layers, printed circuit boards and other components of electronic, optical and / or mechanical systems. One type of nano-composite material has a base material and nanostructures (e.g., nanotubes) dispersed in the base material. Another type of nano-composite material has layers of a base material with nanotube films disposed thereon.

Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallyglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.

A doubled-sided PCD or PCBN compact as well as a new multi-layered PCD and PCBN can be produced using high pressure high temperature processes allowing for increased effective thickness of abrasive tools. A polycrystalline compact can include a substrate having a first surface and a second surface which are non-contiguous. Additionally, a first polycrystalline layer can be attached to the first surface of the substrate and a second polycrystalline layer attached to the second surface of the substrate. The first and second polycrystalline layers can include superabrasive particles bonded together by sintering or chemical bonding with an additional metal. Such double-sided PCD and PCBN compacts as well as a new multiple layered PCD and PCBN allow for increased effective thickness of a tool without suffering from non-homogenous results typical of standard PCD and PCBN compacts, regardless of superabrasive particle size. Each polycrystalline layer can include superabrasive particles of varying particle sizes such that the final tool is tailored for specific abrading characteristics. Such doubled-sided and / or multiple layered PCD and PCBN compacts can be incorporated into a wide variety of abrasive tools for use in cutting, milling, grinding, polishing, drilling and other similar abrasive applications.

A method for forming a final digital color image includes capturing an image using an image sensor having panchromatic pixels and color pixels corresponding to at least two color photoresponses; providing from the captured image a digital panchromatic image and an intermediate digital color image; and using the digital panchromatic image and the intermediate digital color image to provide the final digital color image.

A method for obtaining image data from an image sensor array including the steps of: providing an image sensor array having a first component subset of panchromatic pixels for integrating charge and a second component subset of color pixels for integrating charge; reading pixel charge to produce pixel signals from the first component subset of the panchromatic pixels while exposing the second component subset of color pixels and digitizing and storing the first component subset signals; and reading pixel charge to produce pixel signals from the second component subset of color pixels that were exposed for at least a portion of time during the reading of pixel signals from the first component subset of the panchromatic pixels and digitizing and storing the second component subset signals.

A corrosion control system is disclosed including an anionic oxygen inhibitor, a cationic acid inhibitor or dispersant, and a noxious species inhibitor or scavenger for use in a fluid in contact with a metallic surface at low temperature, moderate temperature and especially at high temperature. A drilling fluid, a completion fluid, a production fluid and a geothermal fluid including an effective amount of the corrosion control system is also disclosed as well as methods for making and using same.

A doubled-sided PCBN and / or PCD compact can be produced using high pressure high temperature processes allowing for increased effective thickness of abrasive tools, decreased delamination, and increased useful service life. A polycrystalline compact can include a substrate having a first surface and a second surface which are non-contiguous. Additionally, a first polycrystalline layer can be attached to the first surface of the substrate and a second polycrystalline layer attached to the second surface of the substrate. The first and second polycrystalline layers can be attached to the substrate via an intermediate layer containing superabrasive particles. Such double-sided PCBN and PCD compacts allow for increased effective thickness of a tool without suffering from non-homogenous results typical of standard PCD and PCBN compacts, regardless of superabrasive particle size. Each polycrystalline layer can include superabrasive particles of varying particle sizes such that the final tool is tailored for specific abrading characteristics. Such doubled-sided PCBN and PCD compacts can be incorporated into a wide variety of abrasive tools for use in cutting, milling, grinding, polishing, drilling and other similar abrasive applications.

A system and method for generating a list is provided. The system includes a seed item input subsystem, an item identifying subsystem, a descriptive metadata similarity determining subsystem and a list generating subsystem that builds a list based, at least in part, on similarity processing performed on seed item descriptive metadata and user item descriptive metadata and user selected thresholds applied to such similarity processing. The method includes inexact matching between identifying metadata associated with new user items and identifying metadata stored in a reference metadata database. The method further includes subjecting candidate user items to similarity processing, where the degree to which the candidate user items are similar to the seed item is determined, and placing user items in a list of items based on user selected preferences for (dis)similarity between items in the list and the seed item.

The present invention includes a method and apparatus for detecting exposure to environmental tobacco smoke by analyzing a sample of breath using electronic sensor technology, including surface acoustic-wave gas sensor technology. The method determines the presence and concentration of substance(s) (or a class of substances) indicative of environmental smoke exposure. Diagnostic software is used to identify substances where a stored library of signatures is compared to the signature obtained from the system. Signal processing and neural networks are preferably utilized in the analysis.

The invention relates to novel carbene ligands and their incorporated monomeric and resin / polymer linked ruthenium catalysts, which are recyclable and highly active for olefin metathesis reactions. It is disclosed that significant electronic effect of different substituted 2-alkoxybenzylidene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes, some of novel ruthenium complexes in the invention can be broadly used as catalysts highly efficient for olefin metathesis reactions, particularly in ring-closing (RCM), ring-opening (ROM), ring-opening metathesis polymerization (ROMP) and cross metathesis (CM) in high yield. The invention also relates to preparation of new ruthenium complexes and the use in metathesis.

Disclosed are toner compositions comprised of a polymer, an optional colorant, and an UV light curable oligomer. Also disclosed are methods for producing a UV curable toner compositions, the toner compositions produced thereby, and methods of utilizing the UV curable toner compositions in various painting applications.

The present invention provides an aggregate of nanofibers having less spread of single fiber fineness values that can be used in wide applications without limitation to the shape and the kind of the polymer, and a method for manufacturing the same. The present invention is an aggregate of nanofibers made of a thermoplastic polymer having single fiber fineness by number average in a range from 1×10−7 to 2×10−4 dtex and single fibers of 60% or more in fineness ratio have single fiber fineness in a range from 1×10−7 to 2×10−4 dtex.

A carbon nanotube-based device (40) includes a substrate (10), a number of alloyed, nano-sized catalytic particles (26) formed on the substrate, and an array of aligned carbon nanotubes (15) extending from the alloyed, nano-sized catalytic particles. The nanotube array bends in an arcuate configuation. A method for making the carbon nanotube-based device includes the steps of: providing a substrate; depositing a catalyst layer on the substrate; depositing two different layers of catalyst-doped materials on different areas of the catalyst layer for accelerating or decelerating the rate of synthesis of the aligned carbon nanotube array; annealing the catalyst and the catalyst-doped materials in an oxygen-containing gas at a low temperature; introducing a carbon source gas; and forming an array of aligned carbon nanotubes extending from the alloyed, nano-sized catalytic particles using a chemical vapor deposition method.

Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.

An electrostatically actuated valve that is relatively small, has relatively low fabrication costs, and consumes relatively low voltage and / or power. Normally closed, normally open, three (or more) way valves, and other configurations are contemplated. These electrostatically actuated valves are suitable for a wide variety of applications, including but not limited to, low power and wireless applications, for example.

The subject invention provides systems and methods for monitoring prescription medications. In particular, systems and methods are provided for monitoring patient compliance with a given prescribed regimen as well as monitoring the origins of a prescription drug. The subject invention provides a central computer and a portable device, wherein the portable device includes at least one sensor for detecting a target marker. The target marker of the invention represents either the presence of a specific prescribed medication or identify the proper origins of a medication.

An image sensor for capturing a color image is disclosed having a two-dimensional array having first and second groups of pixels, arranged in rows and columns, wherein pixels from the first group of pixels have narrower spectral photoresponses than pixels from the second group of pixels; and the placement of the first and second groups of pixels defining a pattern that has a minimal repeating unit including at least six pixels, so that at least some rows or columns of the minimal repeating unit are composed only of pixels from the second group and some rows or columns of the minimal repeating unit are composed only of pixels from the first group, wherein the rows or columns that are composed only of pixels from the first group are composed of at most two colors of pixels from the first group.

Disclosed herein is a plexus of filaments which is composed of groups of filaments, whose filament members are linked together, in a repetitious pattern, and whose filaments may be interlaced or linked to bisecting groups of filaments, creating a patterned plexus whose filament members generally follow spiraling paths, while linking with neighboring filaments, creating a group, or interlaced groups, of tension distributive filaments within a plexus of filaments; said plexus exhibiting greater conformal and constrictive qualities in comparison to the prior art. Also disclosed is a method of producing filament structures for a variety of uses including composite structures with tension displacement properties, and sporting goods requiring conformal load distribution with minimal weight; such as, running shoes.

In solid oxygen ion conducting electrolytes for electrochemical cells based on magnesium oxide and calcium oxide, obtained by the addition of metal fluorides selected from elements in the groups of alkali metals and earth alkali metals to the host oxides of magnesium and calcium, conductivity values are obtained, which are comparable with those of stabilized zirconia, but the magnesium oxide and calcium oxide based oxygen ion conducting electrolytes have a superior thermodynamic stability and, therefore, can operate at much lower oxygen concentrations in comparison with other oxygen ion conducting electrolytes and without becoming noticeably electronically conductive.

New anionic surfactants and methods of preparation which are derived from aromatic or substituted aromatic molecules and alkenesulfonic acid. Wherein the aryl compound is alkylated and sulfonated in one-step with an alkene sulfonic acid prior to sulfonic acid neutralization. The methods allow the functional sulfonate group to be attached to the end of the alkyl chain rather than to the aromatic ring thus allowing for selective substituted groups, either branched, linear or alkoxylated or combinations thereof to be placed on the aryl compound prior to sulfonation and alkylation. The invention uses the alkene sulfonic acid produced from thin-film sulfonation of an alpha-olefin to alkylate benzene, mono-substituted aromatic, poly-substituted aromatic, alkylbenzene, alkoxylated benzene, polycyclic aromatic, mono-substituted polycyclic aromatic, poly-substituted polycyclic aromatic, naphthalene, alkylnaphthalene, phenol, alkylphenol, alkoxylated phenol, and alkoxylated alkylphenolalkyl substituted or polysubstituted cyclic or polycyclic compounds to produce the corresponding sulfonic acid having an additional alkyl group derived from the alpha-olefin used during the thin-film sulfonation which is either linear or branched.

An image processing apparatus is capable of generating distortion-free accurate image data. The image processing apparatus has an image entering unit, an image processor, and a memory. Slice data read by the image entering unit is stored in the memory. The image processor determines whether the slice data stored in the memory is of significance or not. Then, the image processor calculates a moved distance and tilt of the slice data that has been detected as being of significance, and calculates positional coordinates of a reconstructed image area to which the slice data is to be projected, based on the moved distance and tilt of the slice data which have been calculated, and generates reconstructed image data. The generated reconstructed image data is stored in the memory.

The present invention provides a method for fabricating a flexible pixel array substrate as follows. First, a release layer is formed on a rigid substrate. Next, on the release layer, a polymer film is formed, the adhesive strength between the rigid substrate and the release layer being higher than that between the release layer and the polymer film. The polymer film is formed by spin coating a polymer monomer and performing a curing process to form a polymer layer. Afterwards, a pixel array is formed on the polymer film. The polymer film with the pixel array formed thereon is separated from the rigid substrate.

The present invention provides remote interfacing utilising haptic technology. In a first aspect there is provided a haptic grasping interface comprising a plurality of finger interaction points, with actuators connected at one end to an actuator control mechanism. The mechanism is mounted remotely from the grasping interface, inverse to the finger interaction points, for manipulation of these points. The grasping points comprise pulleys which route the actuators through a cable tension and transmission system. A second aspect provides haptic augmentation to an operator, which indicates to the operator the state of a control input to a controlled device. A third aspect provides a means of simulating motion where haptic feedback is provided to a user in correspondence with the movement of the user within a pod environment.

An all-fiber erbium laser oscillating in a passive Q switched mode. The laser includes a crystal saturable absorber that may be Co2+:ZnSe or Cr2+:ZnSe. In preferred embodiments continuous pumping or short pulse pumping may be utilized. The laser is characterized by low threshold high-power, short-pulse generation. In preferred embodiments the threshold is only about 20 mW. The crystals are bleached at extremely low intensity, of about 0.8 kW / cm2 and provide moderate relaxation time of the excited state (290 μs) within a spectral range of about 1400-1800 nm. The simplicity of the design and low cost of that laser 2000).