13results about How to "Wide application" patented technology

The present application relates to a preparation method for an antibody-drug conjugate and an application, and in particular, to a compound, or a tautomer, mesomer, racemate, enantiomer, and diastereomer, or mixture thereof, or a pharmaceutically acceptable salt, prodrug or solvate thereof, a preparation method for the compound and related antibody-drug conjugates, and a use of the same in the preparation of drugs for the treating cancer.

The present application relates to the technical field of electrophoretic particles, more particularly to an electrophoretic particle, a preparation method therefor, and an application thereof. Provided is an electrophoretic particle. The electrophoretic particle includes a shell layer and a core layer, which is wrapped in the shell layer. The core layer includes a plurality of core particles, and the density of the core particles is lower than a density of the shell layer. The electrophoretic particle includes the shell layer and the core layer wrapped in the shell layer, the core layer includes the plurality of core particles, and the structure of the plurality of the core particles makes the shell layer wrapping on surfaces of the plurality of the core particles form a folded structure, thus increasing a surface area of the core layer and improving the bonding tightness between the shell layer and the core layer, and making the shell layer of the resulting electrophoretic particle have relatively strong tightness. Based on this, an overall particle size of each electrophoretic particle can be appropriately reduced, the moving velocity of the electrophoretic particle under the action of the electric field can be improved, and it is ensured such electrophoretic particle will never have the light leakage problem, thereby improving the excellent performance of a device.

The utility model relates to the technical field of wire harness conduction equipment, in particular to a movable support for wire harness conduction equipment, which comprises a bottom frame A and a bottom frame B. An outer rod A is welded at the top of the bottom frame A. An inner rod A is slidably connected to the inner side of the outer rod A. A fixing frame A is fixed at one end, far away from the outer rod A, of the inner rod A through a screw. A supporting rod for supporting the conduction plate is welded to the top of the fixing frame A, an outer rod B is welded to the top of the bottom frame B, an inner rod B is slidably connected to the inner side of the outer rod B, and a fixing frame B is connected to the top of the inner rod B through a screw; through the arrangement of the supporting rod, the fixing plate, the bottom frame A, the bottom frame B, the fixing frame A, the fixing frame B and the fixing assembly, the problems that when an existing movable support used for the wire harness conduction equipment is used, a conduction plate and a conduction machine in the wire harness conduction equipment cannot be used separately, and the wire harness conduction equipment is inconvenient to move are solved.

The present application relates to a preparation method for and an application of an antibody conjugated drug, in particular to a compound, or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt, prodrug, or solvate thereof, preparation methods of the compound and related antibody conjugated drug, and uses thereof in the preparation of drugs for treating cancers.

There has been required a novel and practicable multilayer structure that has enhanced structure stability and, therefore, is improved in the enlargement of device size, easiness in processing, etc. A structure according to the present invention that comprises a core layer comprising a pharmacological ingredient embedded in a chemically crosslinked alginic acid, a cationic polymer layer coating the core layer, and an anionic polymer layer coating the cationic polymer layer.

A high temperature resistant mannanase mutant, comprising at least one mutation site among D49C / I / N, G58D / E / S, H90L, T99Y, K120Y, N124P, T130D / N / P / Q / R / S, Y132F, S136M, S140L / K, T148K, F206Y, A212N / S / P, L257F, S263R, D268A / E / G / P, G273P, S302M / E, S306M / Q, T315P, T353L / F, D360E / N / K, and A362R. The high temperature resistant mannanase mutant has heat resistance significantly higher than the wild type mannanase, and can be widely used in the field of feeds.

The present application relates to the technical field of new materials, and more specifically, it relates to a preparation method of collagen fiber, a collagen fiber, and an application of collagen fiber, including the following steps: (1) spinning solution: soak the collagen material in a solution with a pH of 3.5 to 5.5 and dissolve it, then adjust the pH to 9.9 to 12.5 to form a spinning solution ; (2) as-spun fiber: the spinning solution enters the coagulation bath with a pH of 4.4 to 6.8 for coagulation and spinning to form as-spun fiber.

An application of iron oxide nanoparticles (IONPs) in the preparation of a parathyroid and / or lymph node contrast agent, wherein the particle size of the IONPs is 1-1000 nm, the polydispersity index is <0.3, the zeta-potential is -50 to 50 mV, and the peak value of an ultraviolet-visible absorption spectrum is 100-500 nm. The IONPs may accurately negatively visualize parathyroid glands and trace lymph nodes.

The utility model provides an improved photovoltaic clamp, including first clamping piece, second clamping piece, bolt assembly, first clamping piece includes the first upper roof of C-shaped structure integrated moulding, first support plate, first clamping plate, second clamping piece includes the second upper roof of C-shaped structure integrated moulding, second support plate, second clamping plate, first clamping piece and second clamping piece form the clamping cavity and have second upper roof and top in first upper roof bottom surface after assembling, bolt assembly includes polygonal bolt, second upper roof bottom surface is opposite and is provided with the first hook portion and second hook portion of the restriction polygonal bolt and turn, first hook portion includes first vertical limiting section and first hook, and first vertical limiting section and first hook form first and top step between, second hook portion includes second vertical limiting section and second hook, and second vertical limiting section and second hook form second and top step between. Improved photovoltaic clamp has the advantages of simple structure, convenient installation, low cost, strong applicability.

The present disclosure relates to an anti-CD300c monoclonal antibody and its use for preventing or treating cancer. The anti-CD300c monoclonal antibody according to the present disclosure binds to a CD300c antigen with high specificity and also promotes anticancer immune responses. Thus, this anti-CD300c monoclonal antibody is expected to be effectively used against growth, development, metastasis, and the like of various cancers.

A method of manufacturing a super-junction power device having adjustable resistors connected in parallel between a gate and a source; and the super-junction power device obtained by performing the method are provided. The method includes: preparing a cell structure and the adjustable resistors connected in parallel between the gate and the source of the super-junction power device; preparing contact holes; preparing metal wires; and preparing a passivation layer.

The present application relates to a method for preparing an antibody drug conjugate and an application thereof. Specifically, the present application relates to a compound, or a tautomer, mesomer, racemate, enantiomer, and diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt, prodrug or solvate thereof, as well as a method for preparing the compound and related antibody drug conjugates and use thereof in the preparation of drugs for the treatment of cancers.

This invention provides a pressure balance measurement system for knee replacement surgery, including a pressure signal processing device and a force measuring handle connected via a communication cable. The force measuring handle includes a pressure sensor, a housing, and a support structure. The support structure is connected to the housing via a telescopic tube, which has a bifurcated structure. The main rod of the bifurcated structure is connected to the support structure, and the two branches of the bifurcated structure are each connected to a housing. The distance and angle between the two housings and the support structure are adjustable via the telescopic tube. This invention meets the minimum thickness required for clinical use, has a high pressure measurement range and accuracy, high assessment reliability, an efficient and simple structure, provides bilateral pressure measurement, and the measurement points are adjustable, increasing its versatility in clinical application.