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The present application relates to a preparation method for an antibody-drug conjugate and an application, and in particular, to a compound, or a tautomer, mesomer, racemate, enantiomer, and diastereomer, or mixture thereof, or a pharmaceutically acceptable salt, prodrug or solvate thereof, a preparation method for the compound and related antibody-drug conjugates, and a use of the same in the preparation of drugs for the treating cancer.

The present application relates to a preparation method for and an application of an antibody conjugated drug, in particular to a compound, or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt, prodrug, or solvate thereof, preparation methods of the compound and related antibody conjugated drug, and uses thereof in the preparation of drugs for treating cancers.

The present application relates to a method for preparing an antibody drug conjugate and an application thereof. Specifically, the present application relates to a compound, or a tautomer, mesomer, racemate, enantiomer, and diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt, prodrug or solvate thereof, as well as a method for preparing the compound and related antibody drug conjugates and use thereof in the preparation of drugs for the treatment of cancers.

This invention provides a pressure balance measurement system for knee replacement surgery, including a pressure signal processing device and a force measuring handle connected via a communication cable. The force measuring handle includes a pressure sensor, a housing, and a support structure. The support structure is connected to the housing via a telescopic tube, which has a bifurcated structure. The main rod of the bifurcated structure is connected to the support structure, and the two branches of the bifurcated structure are each connected to a housing. The distance and angle between the two housings and the support structure are adjustable via the telescopic tube. This invention meets the minimum thickness required for clinical use, has a high pressure measurement range and accuracy, high assessment reliability, an efficient and simple structure, provides bilateral pressure measurement, and the measurement points are adjustable, increasing its versatility in clinical application.