18 results about "Acidic amino acids" patented technology

The invention relates to a liquid crystal emulsion composition for skin barrier care. The liquid crystal emulsion composition is characterized by at least containing a component (a) fatty acyl acidic amino acid fatty alcohol ester (general formula I) and a component (b) fatty acyl amino acid salt (general formula II) and / or a cosmetically acceptable medium or carrier. The composition can spontaneously form a lamellar liquid crystal structure in a system, and the arrangement mode of the lamellar liquid crystal structure is highly similar to that of intercellular lipid of a skin cuticle, so that the skin barrier is remarkably strengthened, the transdermal moisture loss is reduced, and a light, smooth and non-greasy skin feeling is brought. The formed liquid crystal structure keeps stable in a temperature range of-18 DEG C to 45 DEG C, and is suitable for various repair cream, emulsion and essence products.

The invention discloses a liquid crystal emulsion composition with a barrier effect. The composition comprises fatty acyl acidic amino acid fatty alcohol ester as shown in a general formula (1) and an alkyl phosphate emulsifier as shown in a general formula (2), a layered liquid crystal structure is formed through self-assembly, and skin cuticle lipid arrangement is simulated. The liquid crystal emulsion composition can enhance the physical barrier of skin, reduce water loss, and maintain the uniformity and stability of liquid crystals under the conditions of temperature change, shear action and long-term storage. Compared with the existing liquid crystal composition, the composition provided by the invention has higher liquid crystal structure stability and also has a barrier protection effect.

This application discloses an HIV antigen comprising the gp41 protein; said gp41 protein contains at least one amino acid residue selected from the following: T at position 85; K at position 98; a basic amino acid R or K at position 109; a neutral amino acid L or I at position 111; a basic amino acid K or R at position 132; N at position 133; and an acidic amino acid D or E at position 139. The HIV antigen of this application has the advantages of high specificity and high sensitivity.

The application discloses a construction method and application of an NLRP3 humanized mouse model, and belongs to the technical field of genetic engineering. The construction method of the NLRP3 humanized mouse model comprises the step of mutating the 708th amino acid of mouse Nlrp3-201 protein into a non-acidic amino acid; the Ensembl ID of the mouse Nlrp3-201 is ENSMUST00000079476.10. It is verified that the 708th amino acid of the mouse NLRP3 protein is mutated into a non-acidic amino acid (for example, alanine), the NLRP3 of the obtained mutant transgenic mouse is similar to human NLRP3, and cannot be cut by caspase-3, and humanization is realized. The mutant mouse model can better reflect the biological processes such as human inflammasome activation, cell pyroptosis and inflammatory reaction, and provides a more accurate animal model for understanding human diseases and drug screening.

The invention relates to a peptide for use in prophylaxis, prevention, inhibition and / or treatment of psoriasis of a mammal, wherein the peptide comprises amino acids joined by peptide bonds, and wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro). The invention also relates to a pharmaceutical composition for use in prophylaxis, prevention, inhibition and / or treatment of psoriasis of a mammal, wherein the pharmaceutical composition comprises a peptide, wherein the peptide comprises amino acids joined by peptide bonds, and wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro). The invention further relates to a composition for skin improvement, a cosmetic composition, a topical skin cream composition and a nutritional compositions, wherein said compositions comprise a peptide comprising amino acids joined by peptide bonds, wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro).

The present application provides an oil-in-water emulsified cosmetic, which comprises (A) a powder, (B) a water-soluble thickening agent, and (C) a surfactant, the content of the (A) component is 1-30% by mass based on the total amount of the cosmetic, the (A) component contains (A1) a powder treated with an N-acyl acidic amino acid, the (C) component contains (C1) a solid nonionic surfactant with an HLB of less than 7 and (C2) a surfactant with an HLB of 7 or more, and the mass ratio [(C1):(C2)] of the (C1) component to the (C2) component is 1.5:1-30:1.

To provide a solid composition containing ibuprofen with improved dissolution properties. [Solution] A solid composition comprising (A) ibuprofen and (B) at least one selected from the group consisting of noscapine, dextromethorphan, and salts thereof (excluding (i) a solid composition that does not contain dextromethorphan or a salt thereof and in which ibuprofen and noscapine or a salt thereof exist as different granules, and (ii) a solid composition that does not contain noscapine or a salt thereof and in which ibuprofen, dextromethorphan or a salt thereof, a polymer that forms a hydrogel, and an organic acid or an acidic amino acid).

A method of treating a tissue exhibiting eosinophil-associated inflammation in a subject is disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of a polymer and a pharmaceutically acceptable excipient. The polymer is formed from an acidic amino acid, such as aspartic acid and / or glutamic acid, or a pharmaceutically acceptable salt thereof. The polymer has an average molecular weight of at least about 5 kDa. The polymer binds to one or more eosinophilic granulocyte proteins in tissue to neutralize the eosinophilic granulocyte proteins and treat eosinophilic granulocyte-associated inflammation.

The invention relates to a spider silk protein membrane material capable of generating electricity by friction and a preparation method and application thereof, a plurality of amino acid residues in flexible regions on two sides of a spider silk protein microcrystalline region are replaced with acidic amino acids or basic amino acids, and spider silk protein modifiers with different flexible region acidic / basic amino acid molar ratios are obtained; the spider silk protein modified body is independently formed or mixed with a conductive material to form a membrane, and the membrane material is formed. By utilizing the method disclosed by the invention, materials needing different piezoelectric properties can be developed, and a foundation is further laid for the industrial production of the recombinant spider silk protein and the wide application of the recombinant spider silk protein in the field of functional materials.

The invention relates to the technical field of adsorbents, in particular to modified sodium alginate as well as a preparation method and application thereof, and the modified sodium alginate is prepared from the following raw materials: sodium alginate, a cross-linking agent, a buffering agent, an activating agent and acidic amino acid. The modified sodium alginate provided by the invention can effectively adsorb and remove methylene blue in water, and can maintain good adsorption performance after multiple cyclic adsorption-desorption.

This application discloses a nuclear localization signal AoNLS and its application in enhancing CRISPR / Cas9 editing in zebrafish. The nuclear localization signal AoNLS is derived from the zebrafish proteome. Through bioinformatics mining and functional screening, a structurally unique amino acid, KRKREAE, was identified, with its amino acid sequence shown in SEQ ID NO:1. This sequence is composed of both basic and acidic amino acids, and its mode of action differs from the single charge-driven mechanism of traditional NLS, achieving a breakthrough improvement in nuclear input efficiency. The Pcs2-AoNLS-GFP system, constructed by fusing AoNLS with GFP protein, showed a 1.56-fold increase in nuclear input efficiency in zebrafish embryos compared to the traditional SV40 NLS. Simultaneously, the Pcs2-AoNLS-Cas9 system, constructed by fusing AoNLS with Cas9 protein, significantly enhanced the editing efficiency of the Stat3 and Amh target genes by 1.72 times and 1.82 times, respectively, compared to the Pcs2-SV40 NLS-Cas9 gene editing system. The AoNLS sequence provided in this application is short and highly efficient, and can be used as a core component of the next-generation gene editing tool nuclear delivery system, with good application prospects in the fields of aquaculture breeding and developmental biology research.

The invention claimed herein relates to a dielectric polishing composition and method thereof. The invention claimed herein particularly relates to a composition comprising: (A) surface-modified colloidal silica particles comprising negatively charged groups on the surface of the particles, wherein the surface-modified colloidal silica particles have a negative charge, a particle size of 60 nm to 200 nm, and a zeta potential of < -35 mV at a pH in the range of > 2.0 to < 6.0; (B) at least one corrosion inhibitor selected from at least one guanidine derivative; (C) at least one iron (III) oxidizing agent; (D) at least one buffering agent selected from at least one acidic amino acid having an isoelectric point (pi) of < 5.0; (E) at least one stabilizer; and (F) an aqueous medium, wherein the pH of the composition is in the range of > 2.0 to < 4.3, and wherein the composition has a polyacrylamide content of < 1 ppm.

This invention discloses a synergistic water-soluble fertilizer composition of macroelements and its application, relating to the field of agricultural fertilizer technology. The composition includes the following components: macroelements comprising nitrogen, phosphorus pentoxide, and potassium oxide, with a mass ratio of 20:20:20; ammonium polyphosphate, potassium dihydrogen phosphate, sulfur-based raw materials, and chelated trace elements; L-type acidic amino acids; and soluble organic matter (DOM). This synergistic water-soluble fertilizer composition of macroelements and its application, by compounding ammonium polyphosphate and potassium dihydrogen phosphate at a mass ratio of 1:(0.1-10) and using L-type acidic amino acids as chelating carriers, allows the chelating ability of ammonium polyphosphate for calcium and magnesium ions and the transport capacity of L-type acidic amino acids for trace elements to synergistically superimpose, thereby effectively inhibiting the formation of insoluble phosphate precipitates by the combination of phosphorus with calcium and magnesium ions in hard water or calcareous soil environments.

The invention belongs to the technical field of cosmetics, and particularly relates to a supramolecular amino acid facial cleanser and a preparation method thereof. The facial cleanser comprises the following components: 15-35% of a basic amino acid surfactant and an acidic amino acid surfactant in a molar ratio of (1-2): 1; 3-6% of cyclodextrin; 5-15% of a skin conditioner; and the balance of water. The preparation method comprises the following steps: adding cyclodextrin into hot water for dissolving, then adding the skin conditioner, stirring and mixing uniformly, then sequentially adding the alkaline amino acid surfactant and the acidic amino acid surfactant, homogenizing and mixing uniformly, naturally cooling to room temperature, adjusting the pH value to 5.5-6.5, and defoaming in vacuum to obtain the product. According to the invention, the amino acid surfactant with a specific ratio is self-assembled to form a supramolecular group, so that the problems that the conventional amino acid facial cleanser is large in crystal, unstable and easy to thicken in the later period are solved, and the cleansing and oil-controlling effects which are synergistically improved are achieved.

The invention relates to a thickening and cleaning composition as well as application and a preparation method thereof, and particularly discloses a self-thickening composition consisting of one or more N-acyl acidic amino acids and / or one salt thereof and one or more ampholytic surfactants. According to the present invention, the preparation method and the application thereof in cosmetics, personal care, home care and other fields have characteristics of excellent thickening property and easy use applicability, and especially can be used in the cleaning formula for improving the foam quality, the mildness and other properties.

This invention provides an amino-PRX (Amino-PRX) vector as a nucleic acid / protein carrier. Amino-PRX freely provides amino groups to the sgRNA and acidic amino acids of Cas9, and CDs rotate and move only by mixing Amino-PRX and Cas9RNP (automatic molecular imprinting), thereby efficiently and easily forming a complex with Cas9RNP and achieving efficient delivery of Cas9RNP into cells. Furthermore, by optimizing the structure of the axon / cap connector and the amino / CD connector, the dynamics of Cas9RNP within cells can be precisely controlled, improving genome editing efficiency.

The object of the present invention concerns a hair restructuring association comprising or alternatively consisting of: (a) a quaternary ammonium salt of formula (I) and (b) at least one sulpho-derivative of vegetable fatty acids, wherein R5, R6 are independently chosen between hydrogen and a radical R0, R0 consists of the following structure of formula (II), R1 is chosen from the group consisting of: hydrogen, methyl, isopropyl, sec-butyl, isobutyl, ethylenemethylthio, benzyl, para-hydroxybenzyl and 3-methylene-1H-indole, R2, R3, R4 are independently chosen from the group consisting of: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, mX− is chosen from the group consisting of: formic acid, acetic acid, unsaturated monocarboxylic acids, adipic acid, aldaric acid, oxalic acid, phthalic acid, azelaic acid, sebacic acid, malonic acid, succinic acid, tartaric acid, glutaric acid, pimelic acid, maleic acid, malic acid, fumaric acid and suberic acid, isocitric acid, citric acid, fatty acids, acidic amino acids, keto acids and aromatic carboxylic acids, m is an integer number comprised between 1 and 22, n is comprised between 2 and 20.

The invention relates to a solid composition, an agent for improving dissolution of ibuprofen, and a method for improving dissolution of ibuprofen. The present invention addresses the problem of providing a solid composition containing ibuprofen having improved dissolution properties. [Solution] A solid composition which contains (A) ibuprofen and (B) at least one substance selected from the group consisting of noscabine, dextromethorphan, and salts thereof, and which does not contain: (i) a solid composition which does not contain dextromethorphan or a salt thereof and in which ibuprofen and noscabine or a salt thereof are present as different granulated materials; and (ii) a solid composition which does not contain noscabine or a salt thereof and comprises ibuprofen, dextromethorphan or a salt thereof, a hydrogel-forming polymer, and an organic acid or acidic amino acid.