14 results about "Tissue binding" patented technology

The invention discloses an umbilical vein catheterization virtual-entity fusion training system based on a novel material, and relates to the technical field of medical simulation training. According to the system, a dynamic three-dimensional umbilical vein anatomical model is constructed through the virtual simulation unit, the entity operation unit adopts a bionic gradient material to simulate neonatal umbilical tissue, and the binding force feedback unit realizes tactile-visual dual-channel interaction. Comprising a multi-source coupling coordinate calibration algorithm, a viscoelastic layered deformation transmission algorithm and the like, and the problems of insufficient operation authenticity and feedback lagging in traditional training are solved by dynamically matching virtual and entity operation spaces and simulating real tissue mechanical response. The novel material preparation unit realizes mechanical property matching with human tissues through a nano-composite process, and the environment simulation unit can reproduce various pathological scenes. The immersion and effectiveness of operation training are remarkably improved, and the method is suitable for standardized training of medical staff in the neonatology department.

This invention relates to compounds and methods for treating cancer. In various embodiments, the compound includes a heptamethine carbocyanine dye (HMCD) component, a camptothecin derivative component, and a linker moiety (L) connecting the HMCD component and the camptothecin derivative component. In various embodiments, the method includes administering a therapeutically effective amount of the compound to a subject, thereby contacting a tissue of the subject with the compound such that the compound binds to the tissue; detecting the compound bound to the tissue, wherein the presence of the compound bound to the tissue is indicative of the cancer in the subject; and delivering the compound to the tissue thereby treating the cancer in the subject.

A fabric or mesh construct, and process for making same, which allows for early wound stability and then transitions to a more compliant state exhibiting a substantially constant macro-porous pore structure through the life of the implant to promote good tissue incorporation without bridging.

The present invention provides a tricyclic compound, an intermediate thereof, a preparation method and an application thereof. Specifically, a compound as shown in Formula I or a pharmaceutically acceptable salt thereof is provided; wherein M is O or NH, R 1 、R 2 、R 3 and R 4 One of the '#imgabs0#'s is H, and the other three are H. n is 0, 1, or 2. This compound can bind well to human AD brain tissue, image amyloid proteins, and serve as a positron emission tomography agent for early diagnosis of Alzheimer's disease and tracking drug efficacy. #imgabs1#

The utility model relates to the technical field of soft tissue focus positioning, in particular to a mammary gland focus marker and puncture positioning device, which comprises a puncture needle, a releaser, a marker and a sheath tube, the front end of a needle handle of the puncture needle is detachably connected with the sheath tube, the marker is arranged inside the puncture needle, the releaser is inserted into the puncture needle, and the sheath tube is detachably connected with the needle handle of the puncture needle. The puncture needle comprises a puncture needle handle, a puncture needle sheath is fixedly connected to the front end of the puncture needle handle, a locking device is fixedly connected to the rear end of the puncture needle handle, the releaser comprises a pushing handle, and a pushing rod is fixedly connected to the front end of the pushing handle. The spherical lantern structure is designed, large anchoring force is achieved, the developing effect is enhanced through the unique three-dimensional structure of the spherical lantern structure, accurate positioning is easier, and therefore tiny focuses are effectively cut off.

The present application relates to a kind of mussel mucin composite gel and its preparation method and purposes, including mussel mucin, bioactive ingredient, material B, biological lubricating material, crosslinking agent, analgesic drug and solvent;The mass ratio of mussel mucin and material B is 3:2~4:1, and material B is polyanion material or amphiphilic polyelectrolyte material.The mussel mucin composite gel of the present application is used as skin filling material injection, and the skin filling material is used for filling and supporting shaping in dermis middle layer, subcutaneous layer or periosteum upper level.The mussel mucin composite gel of the present application has excellent anti-degradation performance, high tissue adhesion performance, low water absorption swelling performance, and stronger tissue combination, can effectively avoid the displacement of gel after injection, can long-term maintain filling volume in dermis middle layer, subcutaneous or periosteum surface, with excellent volume stability.

The invention provides a dual-targeting multi-mode diagnosis and treatment integrated probe as well as a preparation method and application thereof. The probe comprises a marking tracing part, a target point binding ligand and a cyanine fluorescent dye part, the probe can be rapidly combined with target tissues after reaching a body, the target tissues with high target point expression can be effectively imaged in a bimodal mode and effectively distinguished, and the probe can effectively perform surgical navigation on the target tissues with high target point expression, so that the target tissues with high target point expression can be obtained. The probe is a diagnosis and treatment integrated probe with a good clinical application prospect.

The application discloses a marker and a pushing device, and relates to the technical field of medical devices. The marker is a spring coil, and the spring coil is provided with a plurality of reflecting surfaces. The plurality of reflecting surfaces are divided into a dense reflecting part and a sparse reflecting part. The dense reflecting part is used for forming a dense bright band image during development, and the sparse reflecting part is used for forming a spaced bright band image during development. The application provides a marker for breast lesion positioning, which enhances the development of the marker under ultrasound, and the marker can quickly recover to an unfolded state after being released to a target position, and is firmly combined with tissue and is not prone to displacement.

The invention discloses a tissue adhesive material as well as a preparation method and application thereof. The tissue binding material disclosed by the invention is bi-crosslinked network hydrogel formed by temperature-sensitive crosslinking and Schiff base reaction; the temperature-sensitive crosslinking is generated by a modified polylactide caprolactone-polyethylene glycol-polylactide caprolactone copolymer, the copolymer is subjected to gel transition when the temperature is close to the body temperature, and the hydrogel is formed through crosslinking; the Schiff base reaction is generated by the polyamino polymer and the aldehyde group of the modified polylactide caprolactone-polyethylene glycol-polylactide caprolactone copolymer. Hydrogel crosslinked with a multi-amino polymer is formed in situ on the basis of modified polylactide caprolactone-polyethylene glycol-polylactide caprolactone copolymer hydrogel, so that bi-crosslinked network hydrogel is formed, and the tissue bonding material is good in biocompatibility, has biodegradability, is non-toxic, and can be applied to the field of tissue bonding. And firm adhesion with tissues can be generated, so that gas leakage and blood leakage of damaged tissue parts are prevented.

The invention relates to the technical field of bleeding detection, in particular to a laparoscope bleeding detection auxiliary method and system based on image processing, and the method comprises the following steps: generating a de-noised operation image, converting the de-noised operation image into a Lab color space, and constructing a static blood candidate region in combination with a local entropy value; and calculating optical flow field vectors of adjacent frames, mapping the optical flow field vectors to the candidate regions to extract dynamic diffusion features, fusing textures and spatial-temporal features to calculate a bleeding risk value, and outputting an early warning result. According to the method, by introducing a highlight mask and a morphological repair mechanism, light reflection of a surgical instrument and illumination interference of a wet tissue surface are eliminated, liquid blood and solid visceral organ tissues with red characteristics are effectively distinguished by utilizing texture energy characteristics extracted by a gray-level co-occurrence matrix, and an inter-frame optical flow field analysis means is combined, so that the detection accuracy is improved. The dynamic diffusion behavior of blood under the action of gravity or pressure is accurately captured, and the problem that old bloodstains and active hemorrhage cannot be recognized through a static color discrimination method is solved.

A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

The present invention provides a multi-layer hybrid coating with a biomimetic cell membrane structure and a preparation method thereof. For the first time, by mimicking the cell membrane structure, the hydrophobicity and bioactivity are organically combined in the same coating, solving the problems of poor tissue integration and osteogenesis performance of traditional organic hydrophobic coatings. Moreover, a transition layer mainly composed of MgF2 is used to enhance the interfacial bonding force between the coating and the magnesium substrate, improving the mechanical stability of the coating and the reliability during long-term use. And through the verification of subcutaneous implantation experiments in rats, it is proved that the coating has excellent in vivo corrosion resistance and biocompatibility, can effectively inhibit the in vivo corrosion of magnesium-based materials, and has good tissue binding potential. In summary, the multi-layer hybrid coating with a biomimetic cell membrane structure and the preparation method thereof proposed by the present invention can not only inhibit the biological corrosion of magnesium, but also have the potential to promote bone bonding and generation, especially in the fields of orthopedics and dental restoration, etc., and has broad application prospects.

The application provides a double-targeting multi-modal diagnosis and treatment integrated probe and a preparation method and application thereof. The probe provided by the application comprises a labeling tracer part, a target point binding ligand and a cyanine fluorescent dye part. After the probe reaches the body, the probe can be quickly combined with a target tissue, can effectively perform double-modal imaging on a target tissue with high expression of a target point and can effectively distinguish the target tissue, and the probe can effectively perform surgical navigation on the target tissue with high expression of the target point, so that the probe is a diagnosis and treatment integrated probe with very promising application in clinical practice.