70 results about "Small intestine submucosa" patented technology

A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.

Devices and methods for treating diseased or damaged portions of an intervertebral region are provided. In particular, intervertebral implants that can include use of a tissue regeneration structure having small intestine submucosa are described. The intervertebral implants can be utilized with any combination of load bearing structures for supporting loading on the implant, shaping structures for biasing the configuration of the implant, collapsible support structures for shaping the implant, and other features. Implants can also be formed with an enclosure to contain a filling material, such as an injectable small intestine submucosa formulation. Methods of delivering and utilizing the various implants are also discussed.

Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.

A composite stent graft has a balloon expandable stent portion ( 3 ), a tubular graft material portion ( 1 ) inside or outside of the balloon expandable stent portion and self expanding stents ( 5 ) associated with the tubular graft material portion. Part ( 7 ) of the balloon expandable stent portion can extend beyond the proximal end ( 9 ) of the tubular graft material portion. The tubular graft material can be polytetrafluoroethylene, Dacron, Thoralon(TM), polyamide, small intestine submucosa, collagenous extracellular matrix material, or any other suitable biocompatible material. A method of deploying which includes flaring a part ( 7 ) of the balloon expandable stent portion is also discussed.

A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

An implant is disclosed including a bio-compatible implant body that can be provided with a tip, or interconnected by one or more filaments. The implant body can be formed of a variety of biocompatible materials, including bio-remodelable materials such as small intestine submucosa. Methods are disclosed for assembly of the implant. Additionally, a method is disclosed for delivering the implant to a desired location in a patient.

A medical device (40) including a collagenous biomaterial (10) for causing embolus and treating an aneurysm. The collagenous biomaterial (10) includes a small intestine submucosa (12) that is configured into various components (16) for causing a vascular occlusion or a packing aneurysm lumen.

A stent tissue graft prosthesis (20) for repairing, excluding and/or reinforcing a vessel, duct and the like in a patient. The prosthesis includes an inner expandable stent (21) of which a tissue graft (24) and preferably a multilayered tissue construct (33) is disposed thereon for application to the host tissue of a vessel, duct and the like. The tissue construct includes an extracellular matrix material (36) such as small intestine submucosa (37) for remodeling the host tissue into the prosthesis. The prosthesis further includes an outer tubular member (25) such as an outer expandable stent (44) for retaining the tissue graft on the inner stent. The ends of the inner and outer stents are coincident with or extend beyond the ends of the tissue graft to prevent eversion or fold back of the tissue graft during withdrawal of a delivery catheter in a placement procedure.

The invention provides a biological repair tablet for herniae and a preparation method thereof. The repair tablet uses small intestine submucosa tissues of inbred line animals without cell and DNA (deoxyribonucleic acid) components as the raw material, completely reserves the extracellular matrix component and structure, and has a micropore structure. The preparation method of the repair tablet comprises the following operation steps: determination of animal source, pretreatment and rough cleaning of small intestine tissues, virus inactivation, cell removal, DNA removal treatment, formation, packaging and sterilization. The biological repair tablet for herniae prepared by the method uses an inbred line animal as an animal source, and thus, the hereditary features are pure, stable and uniform, thereby radically ensuring the stability and uniformity of different batches of products; and the biological repair tablet for herniae has fewer animal source DNA residues, completely reserves the three-dimensional structure of natural ECM, and has the advantages of low immune source property and high infection resistance.

The invention provides a neural restoration material, and a preparation method and application thereof. The neural restoration material is characterized in that the neural restoration material contains collagen, polysaccharose substances, active factors and nerve regeneration promoting factors; the neural restoration material is of a three-dimensional reticular porous structure; no immunogenicity exists; the degradation in vivo is realized; the neural restoration material can be in a flaky shape or a hollow tube shape. The neural restoration material is manufactured by small intestine submucosa tissues of pigs; the injured nerve can be effectively protected; the nerve regeneration protection microenvironment is formed; the injured nerve regeneration is promoted; a barrier effect can also be achieved; the injured nerve position is effectively isolated from peripheral tissues; fibroblasts in the peripheral tissues are prevented from invading the injured nerve position.

The invention discloses a polyurethane (PU)/small intestine submucosa (SIS) membrane composite material which is prepared according to the following steps: a, uniformly mixing anion waterborne PU emulsion and SIS membranes, and performing freeze-drying formation in vacuum, wherein the use amount of the SIS membranes is 0.01-0.03 times (w/w) of that of the PU emulsion, the average particle size of the PU emulsion is 15.18-42.86nm, and the solid content of the PU emulsion is 3-21%; and b, performing cross-linking, and freeze-drying in vacuum, thereby obtaining the PU/SIS membrane composite material. The PU/SIS composite has excellent properties of PU and SIS, has good rebound resilience property and mechanical property, also has biological activity and biocompatibility, can be used for inducing and promoting regeneration and remediation of tissue structures and overcoming the defects that a conventional soft tissue defect remediation material only has single property, the application is limited and the like, and has good application prospect.

The present invention provides a method for preparing a biomaterial involving extracting Collagen Type I (Col I) protein from small intestine submucosa (SIS) under conditions that preserve the native helical configuration. The extract of the present method contains a substantial amount of the alpha helical form of Col I. Further the present method includes inducing the Col I protein to form a polymer material in solution or on a target surface.

The invention provides a biological repair tablet for endocranium and a preparation method thereof. The repair tablet uses small intestine submucosa tissues of inbred line animals without cell and DNA (deoxyribonucleic acid) components as the raw material, completely reserves the extracellular matrix component and structure, and has a micropore structure. The preparation method of the repair tablet comprises the following operation steps: determination of animal source, pretreatment and rough cleaning of small intestine tissues, virus inactivation, cell removal, DNA removal treatment, formation, packaging and sterilization. The biological repair tablet for endocranium prepared by the method uses an inbred line animal as an animal source, and thus, the hereditary features are pure, stable and uniform, thereby radically ensuring the stability and uniformity of different batches of products; and the biological repair tablet for endocranium has fewer animal source DNA residues, completely reserves the three-dimensional structure of natural ECM, and has the advantages of low immune source property and high infection resistance.

The invention discloses a preparation method of a polyurethane/small intestine submucosa composite material, which comprises the following steps: a. evenly mixing an anionic water-based polyurethane emulsion and small intestine submucosa, and carrying out vacuum freeze-drying to form, wherein the small intestine submucosa is 0.01-0.03 time of the polyurethane emulsion (w/w), the average particle diameter of the polyurethane emulsion is 15.18-42.86nm, and the solid content is 3-21%; and b. crosslinking, and carrying out vacuum freeze-drying. The composite material prepared by the method has favorable properties of the polyurethane and SIS (styrene-isoprene-styrene), has the advantages of favorable resilience, favorable mechanical properties, favorable bioactivity and favorable biocompatibility, can induce and promote the regeneration restoration of the tissue structure, overcomes the defect that the existing soft tissue defect restoration material only has the properties in a single aspect and is limited in application, and has favorable application prospects.

A diverticular remodeling technique comprises the introduction of a remodeling agent into the diverticulum to promote permanent closure of the diverticular sac. In disclosed exemplary embodiments, the diverticulum is accessed non-invasively and optionally cleaned to remove unwanted matter therefrom. The remodeling agent is introduced into the diverticular interior and the neck of diverticulum is closed (as necessary) to prevent egress of the remodeling agent. The remodeling agent can be any of a variety of materials, including small intestine submucosa (SIS) collagen or other absorbable fibrosis materials in gel, liquid or solid form. An endoscopic device may be used that includes a multi-lumen flexible catheter having a distal end adapted to be steered through a patient and a proximal end that remains outside the patient's body.

The invention provides an anal fistula biological suppository and a preparation method thereof. The anal fistula biological suppository uses small intestine submucosa tissues of inbred line animals without cell and DNA (deoxyribonucleic acid) components as the raw material, completely reserves the extracellular matrix component and structure, and has a micropore structure. The preparation method of the anal fistula biological suppository comprises the following operation steps: determination of animal source, pretreatment and rough cleaning of small intestine tissues, virus inactivation, cell removal, DNA removal treatment, formation, packaging and sterilization. The anal fistula biological suppository prepared by the method uses an inbred line animal as an animal source, and thus, the hereditary features are pure, stable and uniform, thereby radically ensuring the stability and uniformity of different batches of products; and the anal fistula biological suppository has fewer animal source DNA residues, completely reserves the three-dimensional structure of natural ECM, and has the advantages of low immune source property and high infection resistance.

The invention relates to injectable decellularized small intestinal submucosal matrix particles and a preparation method and the application thereof, and belongs to the field of regenerative medicine.The preparation method of the injectable decellularized small intestinal submucosal matrix particles comprises the following steps: (1), taking an animal small intestine tissue, and sequentially rinsing, sterilizing and repeatedly freezing and thawing; (2), shearing the animal small intestine tissue, scraping off a mucosal layer, a muscle layer and a serosa layer of the small intestine to obtaina stripped small intestine submucosa, and soaking the stripped small intestine submucosa in a sodium chloride solution; (3), decellularizing the small intestine submucosa, and then rinsing; (4), soaking the small intestine submucosa in a buffer solution, then putting into a descaling agent, extracting while shaking, and rinsing; (5), soaking the small intestine submucosa in the buffer solution, performing freeze drying, and grinding to obtain the injectable decellularized small intestinal submucosal matrix particles. The injectable decellularized small intestinal submucosal matrix particles prepared by the preparation method provided by the invention are rich in bioactive component and structurally loose and porous.

The invention relates to a uterine cavity implant as well as a preparation method and application thereof. The uterine cavity implant is characterized by having a bagged structure. The uterine cavity implant comprises a substrate material of animal small intestine submucosa subjected to decellularization treatment. An implantable medical device for preventing and treating intrauterine adhesion comprises a biological tissue substrate material. The present decellularization technology for a biological repairing material is improved; compared with the present product, the biological tissue substrate material provided by the invention has the advantages of lower DNA residual quantity, lower immunogenicity, higher anti-infection capacity and higher repairing capacity; and the uterine cavity implant is beneficial to the recovering of tissues, such as, uterine cavity base layer, submucosa and mucous layer. Besides, the invention prepares the biological repairing material into the uterine cavity built-in structure which is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar forming, so that the intrauterine adhesion problem is solved, and the accordingly generated sterility problem also can be solved.

Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.