Neural restoration material, and preparation method and application thereof

Abstract

The invention provides a neural restoration material, and a preparation method and application thereof. The neural restoration material is characterized in that the neural restoration material contains collagen, polysaccharose substances, active factors and nerve regeneration promoting factors; the neural restoration material is of a three-dimensional reticular porous structure; no immunogenicity exists; the degradation in vivo is realized; the neural restoration material can be in a flaky shape or a hollow tube shape. The neural restoration material is manufactured by small intestine submucosa tissues of pigs; the injured nerve can be effectively protected; the nerve regeneration protection microenvironment is formed; the injured nerve regeneration is promoted; a barrier effect can also be achieved; the injured nerve position is effectively isolated from peripheral tissues; fibroblasts in the peripheral tissues are prevented from invading the injured nerve position.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a nerve repair material, which is used for compounding growth factors in the immunogen-removing matrix of the small intestinal submucosa, protecting damaged and defective peripheral nerves, preventing tissue adhesion and inducing nerve repair. Background technique [0002] Peripheral nerves pervade the skin, mucous membranes, muscles, bones, joints, blood vessels, and internal organs of the whole body. Therefore, human tissues will be affected by peripheral nerves due to stretching, cutting, compression, burns, ischemia, etc., causing nerve damage. Peripheral nerves are the cell protrusions of neurons, also known as nerve fibers, composed of axons, myelin sheaths and Schwann sheaths. The function of the axon is the conduction of nerve impulses between neurons and nerve terminal structures, myelin sheath prevents the diffusion of excitation, and Schwann sheath is comp...

AI Technical Summary

Problems solved by technology

[0003] The traditional method of repairing nerves is limited to sutures, and does not use biomaterials for damage protection. After sutures are sutured, edema will appear at the anastomosis, and excessive proliferation of a large number of fibroblasts will lead to fibrosis at the anastomosis. If the local scar Or tissue adhesion, it will seriously affect the recovery of nerve function

At the same time, most nerve injuries are accompanied by muscle, tendon, and fascia injuries. The repair of these tissues is mainly based on scar repair, which will also lead to excessive scar formation around the nerve anastomosis and affect nerve regeneration.

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