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Polyurethane (PU)/small intestine submucosa (SIS) membrane composite material and application thereof

A technology of small intestinal submucosa and composite materials, applied in medical science, prostheses, etc., can solve the problems of application limitations and single performance, and achieve good histocompatibility, excellent mechanical properties, tensile strength and elongation at break The effect of high elongation

Active Publication Date: 2015-01-28
睿博欣源(成都)生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a polyurethane / small intestinal submucosa (PU / SIS) composite material, which has the excellent properties of polyurethane and SIS, has good resilience performance, mechanical properties, and has biological activity and biocompatibility , can induce and promote the regeneration and repair of tissue structures, and overcome the shortcomings of existing soft tissue defect repair materials that only have a single performance and limited applications

Method used

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  • Polyurethane (PU)/small intestine submucosa (SIS) membrane composite material and application thereof
  • Polyurethane (PU)/small intestine submucosa (SIS) membrane composite material and application thereof
  • Polyurethane (PU)/small intestine submucosa (SIS) membrane composite material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1 Preparation of PU / SIS composite material of the present invention

[0086] 1. Preparation of anionic water-based polyurethane emulsion

[0087] 1) Prepolymerization: Add isophorone diisocyanate (IPDI) and polytetrahydrofuran 1000 (PTMG 1000) with a molar ratio of 1.45:0.5, in which isophorone diisocyanate is 0.1mol, into a three-necked flask, and add 0.2 ml stannous octoate catalyst, pre-polymerized at 74°C for 2h50min;

[0088] 2) Chain extension: 2,2-dimethylolbutyric acid (DMBA) with a PTMG 1000 / DMBA molar ratio of 5:5 was reacted at 54° C. for 3 h. Observe the viscosity of the system during the reaction process. If necessary, add an appropriate amount of acetone to adjust the viscosity of the reaction system. Visually observe the viscosity of the reaction system that does not accumulate on the stirring rod during the stirring process, so that the reaction can be maintained in a stable state;

[0089] 3) Neutralization and emulsification: at room tempe...

Embodiment 2

[0110] Embodiment 2 Preparation of PU / SIS composite material of the present invention

[0111] 1. Preparation of anionic water-based polyurethane emulsion

[0112] 1) Prepolymerization: Add isophorone diisocyanate (IPDI) and polytetrahydrofuran 1000 (PTMG 1000) with a molar ratio of 1.45:0.5, in which isophorone diisocyanate is 0.1mol, into a three-necked flask, and add 0.2 ml stannous octoate catalyst, pre-polymerized at 74°C for 2h50min;

[0113] 2) Chain extension: 2,2-dimethylolpropionic acid (DMPA) with a molar ratio of PTMG 1000 / DMBA of 5:5 was reacted at 54° C. for 3 h. Observe the viscosity of the system during the reaction process. If necessary, add an appropriate amount of acetone to adjust the viscosity of the reaction system. Visually observe the viscosity of the reaction system that does not accumulate on the stirring rod during the stirring process, so that the reaction can be maintained in a stable state;

[0114] 3) Neutralization and emulsification: at room ...

Embodiment 3

[0126] Embodiment 3 Preparation of PU / SIS composite material of the present invention

[0127] 1. Preparation of anionic water-based polyurethane emulsion

[0128] Same as Example 2.

[0129] 2. Preparation of SIS powder

[0130] Same as Example 1.

[0131] 3. Preparation and molding of PU / SIS composite materials

[0132] 1) Preparation: 0.3 g of SIS powder was added to 10 g of polyurethane emulsion with a solid content of 21%, and stirred at room temperature for 3 hours to obtain a polyurethane / SIS sol.

[0133] 2) Forming: Pour the sol into a 24-well plate, pre-freeze at -40°C, and vacuum freeze-dry to form.

[0134] 3) Cross-linking: Soak the obtained material in 2.5% (w / v) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride at pH 5.5 for twice the volume of the material (EDC), after cross-linking at room temperature for 36 h, washed with saturated brine three times to remove residual EDC. Wash the material with a large amount of deionized water, freeze-dry, a...

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Abstract

The invention discloses a polyurethane (PU) / small intestine submucosa (SIS) membrane composite material which is prepared according to the following steps: a, uniformly mixing anion waterborne PU emulsion and SIS membranes, and performing freeze-drying formation in vacuum, wherein the use amount of the SIS membranes is 0.01-0.03 times (w / w) of that of the PU emulsion, the average particle size of the PU emulsion is 15.18-42.86nm, and the solid content of the PU emulsion is 3-21%; and b, performing cross-linking, and freeze-drying in vacuum, thereby obtaining the PU / SIS membrane composite material. The PU / SIS composite has excellent properties of PU and SIS, has good rebound resilience property and mechanical property, also has biological activity and biocompatibility, can be used for inducing and promoting regeneration and remediation of tissue structures and overcoming the defects that a conventional soft tissue defect remediation material only has single property, the application is limited and the like, and has good application prospect.

Description

technical field [0001] The invention relates to a polyurethane / small intestinal submucosa composite material and its application. Background technique [0002] An ideal soft tissue repair material should have the following properties: (1) biocompatibility, such as cell compatibility, tissue compatibility, etc.; (2) excellent mechanical properties, such as tensile strength, resilience, etc. In addition, soft tissue repair materials also need a suitable three-dimensional porous structure, which is conducive to the growth and differentiation of cells, tissue regeneration and the delivery of nutrients. [0003] At present, there are two main categories of soft tissue repair materials: (1) synthetic polymer materials, such as polyurethane, which have excellent physical and mechanical properties, but do not have biological activity and cannot promote tissue regeneration; (2) natural extracellular matrix ( extracellular matrix (ECM), such as collagen, gelatin, small intestinal sub...

Claims

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Application Information

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IPC IPC(8): C08L75/08C08L89/00C08L5/00C08G18/66C08G18/48C08G18/34C08G18/10C08J9/28A61L27/38A61L27/18A61L27/56A61L27/50
Inventor 解慧琪笪琳萃龚梅
Owner 睿博欣源(成都)生物科技有限责任公司
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