Mold for preparing accellular small intestine submucosa matrix material
A small intestinal submucosa and matrix material technology, applied in the field of medical biomaterials, can solve the problems of affecting material porosity, destroying three-dimensional structure, etc., and achieve the effect of ensuring porosity
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Embodiment 1
[0020] The mold used for preparing the matrix material of the decellularized small intestine submucosa in this example consists of two parts: a negative sheet and a pressing net. Described bottom film is the square plate that pin is provided with on four sides, and described pin is perpendicular to square plate, as figure 1 shown. The press net is a square frame with a square frame structure or a mesh structure inside, and the four side lengths of the press net are all 1-3 cm shorter than the negative film. The unit shapes of the network structure include square, rhombus and circle. The frame structure pressing net is as figure 2 As shown, the mesh structure pressing net is as image 3 shown (shown as a rhombus). The height of the needles is 0.5-1.5 cm, the diameter is 0.5-2.0 mm, and the distance between the needles is 0.5-2 cm. There is welding between the needle and the square plate. The negative, the needle on the negative, and the pressing net are all made of 316L ...
Embodiment 2
[0022] The porosity of the decellularized porcine small intestinal submucosa matrix material prepared by using the mold provided in Example 1 was measured by mercury intrusion porosimetry, and compared with the product of Biodesign Surgisis. Results: The porosity of the acellular porcine small intestinal submucosa matrix material prepared by the mold provided in Example 1 was 87.8±2.51, and the porosity of the Biodesign Surgisis product was 78.3±6.38.
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