24results about How to "Promote remodeling" patented technology

The invention relates to the technical field of medical apparatus and instruments, in particular to a scar rehabilitation therapeutic apparatus for realizing treatment based on AI evaluation analysis, which comprises a host, an AI evaluation system and a magnetic treatment component, and is characterized in that the host comprises a shell and an electric control system; the AI evaluation system comprises a data acquisition module and a treatment planning module; the data acquisition module is used for acquiring human body scar area information, the treatment planning module identifies data acquired by the data acquisition module, scar information is obtained after the data are identified and processed, and a scar rehabilitation treatment scheme is planned according to the scar information; the electric control system controls the magnetic treatment assembly to perform scar rehabilitation treatment according to the scar rehabilitation treatment scheme; the magnetic treatment assembly comprises a magnetic fixing device, a magnetic driving device and a magnetic patch; the magnetic patch is attached to a human body scar area, and the magnetic driving device executes a scar rehabilitation treatment scheme under the control of the electric control system, so that the magnetic patch rotates and moves.

The invention discloses a nucleic acid tetrahedron DNA-quercetin compound and application of the nucleic acid tetrahedron DNA-quercetin compound in treatment of retinal neovascular diseases. In the nucleic acid tetrahedron DNA-quercetin compound disclosed by the invention, a quercetin molecule is connected to one single-stranded DNA of four single-stranded DNAs of a nucleic acid tetrahedron through an azide coupling reaction. The compound is stable in physical property, quantitatively carried quercetin molecules guarantee the stability of the treatment effect of the compound, generation of new vessels can be effectively prevented, remodeling of retina non-perfusion area vessels can be promoted, retina vascular injury can be recovered, a new strategy is provided for treatment and prevention of retina neovascular diseases, and the compound is worthy of popularization and application. Meanwhile, compared with tFNAs-QUE obtained through an existing electrostatic adsorption method, the tFNAs-QUE synthesized through the azide coupling method has a better treatment effect, pathological neovascularization is greatly reduced, and meanwhile generation of physiological blood vessels in a non-vascular region is obviously promoted.

The invention provides a skin care composition containing stem cell extract as well as a preparation method and application of the skin care composition, and belongs to the technical field of cosmetics. The method comprises the following steps: mixing and culturing the extracted urine-derived stem cells and pilose antler stem cells in a DMEM culture medium added with epidermal growth factors, cholera toxin, penicillin, streptomycin, transferrin, IL-2 and IL-15, then separating a culture solution to obtain mixed exosomes, mixed stem cells and extracellular matrixes, preparing the mixed stem cells into stem cell lipidosome, and preparing the stem cell lipidosome. Embedding the stem cell extract and the mixed exosome into titanium dioxide / silicon dioxide microspheres, adding into an extracellular matrix, and uniformly dispersing to obtain the skin care composition containing the stem cell extract. The skin care composition containing the stem cell extract prepared by the invention can obviously prolong the preservation period of stem cells and exosomes and improve the repair and improvement of the stem cells and the exosomes on skin, and the prepared composition has better effects of resisting aging, whitening, promoting skin elasticity, resisting wrinkles and the like, and has a wide application prospect.

The invention relates to a double-layer microneedle patch and a preparation method and application thereof.The double-layer microneedle patch comprises a drug delivery unit and an adhesion unit, the drug delivery unit is a GCM-MN microneedle array, the adhesion unit is a CSH hydrogel patch, and when the double-layer microneedle patch is used, firstly, the GCM-MN microneedle array acts on a wound through pressure, and then the CSH hydrogel patch covers the GCM-MN microneedle array. The CSH hydrogel patch is beneficial to creating a wet healing environment, has excellent adhesion stability and skin adaptability and provides an adhesion barrier for a wound, and the GCM-MN microneedle array has good cell compatibility, cell affinity, blood compatibility and biodegradability. Along with the degradation of the microneedle array at the wound, the packaged GCM nanoparticles are continuously released and go deep into the wound. Therefore, the double-layer microneedle patch disclosed by the invention has huge clinical application potential in the field of infectious wound treatment.

The invention provides treatment equipment based on electrical stimulation and mild hypothermia. The treatment equipment can be applied to the technical field of medical equipment. The treatment equipment comprises a wearable module which comprises a plurality of stimulation electrodes used for performing electrical stimulation on a preset area of the head; the plurality of temperature sensors are used for collecting the area temperature of a preset area of the head; the cooling water pipeline is used for conducting heat dissipation on the preset area of the head based on circulating cooling water flowing through the cooling water pipeline; the plurality of stimulating electrodes are arranged on the first side of the waterproof layer, and the cooling water pipeline is arranged on the second side of the waterproof layer; the electric excitation control module is electrically connected with the plurality of stimulating electrodes respectively, and the electric excitation control module is used for adjusting the electric stimulation intensity of the plurality of stimulating electrodes; and the heat exchange module is connected between the water inlet and the water outlet of the cooling water pipeline, is electrically connected with the plurality of temperature sensors at the same time, and is used for adjusting the temperature and the flow velocity of the circulating cooling water according to the regional temperature.

The invention discloses an auxiliary rehabilitation method for a stroke patient and related equipment. The method comprises the following steps: detecting physical sign information of a hand of a patient, wherein the physical sign information comprises joint motion range information, muscle force information and muscular tension information; matching training music for the patient based on the physical sign information of the hand of the patient; a training instruction is generated according to the rhythm of the training music so as to assist rehabilitation, and the training instruction is used for indicating the hand movement content. The problems that in an existing rehabilitation device combining music and gloves, a single instruction or the combination of single music rhythm and movement is commonly used, synchronous stimulation of an audio-visual channel is lacked, and the oneness and limitation of the training process are ignored can be solved.

The invention relates to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition for treating varicocele, a preparation method and an application thereof; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of fennel, 5-10 parts of cinnamon bark, 10-15 parts of angelica sinensis, 5-10 parts of wolfberry, 10-15 parts of lindera striata, 3-5 parts of agarwood, 10-15 parts of curcuma zedoaria, 10-15 parts of turmeric, and 20-30 parts of rhodiola rosea. The formula is formulated based on the principles of breaking up blood and promoting qi, eliminating accumulation and relieving pain. In the formula, Rhodiola rosea and fennel are the main medicines, cinnamon, angelica and Linderae strychnos are the auxiliary medicines, and wolfberry, agarwood, Curcuma zedoaria and turmeric are the adjuvants. It combines movement and stillness, attacks and supplements at the same time, and promotes blood circulation and qi circulation at the same time, which embodies the saying that "qi is the commander of blood" and "blood is the mother of qi". It can significantly improve the various symptoms caused by varicocele. At the same time, it can be combined with surgery for the treatment of varicocele, significantly reducing postoperative complications and the risk of recurrence, and is suitable for large-scale promotion and application.

The invention provides an amnion-sourced engineered electric patch wound dressing as well as a preparation method and application thereof, and belongs to the technical field of medical wound dressings. The engineered electric patch wound dressing is of a double-layer structure and comprises a moisture absorption layer and a volatilization layer, the double-layer structure is formed through physical pressing, the moisture absorption layer is a natural amnion, and the volatilization layer is hydrogel doped with carbon black particles. According to the engineered electric patch wound dressing, the biological activity of the natural amnion is utilized, and the wound repairing speed is increased; hydrogel doped with carbon black particles is constructed, a volatilization layer with the high moisture volatilization characteristic is prepared, meanwhile, by means of the moisture absorption characteristic of a natural amnion, wound exudate is efficiently absorbed, the engineered electric patch wound dressing with the wet electricity characteristic is obtained, and under an electric field constructed by the patch, the wound dressing can be used for wound dressing with the wet electricity characteristic. The repair degree of wound tissues is remarkably improved, meanwhile, differentiation of nerve cells is greatly promoted, and high-level repair of wounds is facilitated.

The utility model discloses a mounting and connecting structure for an additional stent and an aorta covered stent. The mounting and connecting structure comprises the aorta covered stent and a macromolecular polyester material additional stent which can be absorbed by a human body, the additional bracket is tubular and is provided with a grid filiform structure formed by laser engraving; the wire diameter of the grid is the same as the wall thickness; the aorta covered stent is also provided with covered latticed textures; the additional stent can be mounted at the end part of the aorta covered stent in a fastened butt-connection or cross-connection or stacked connection manner; the additional stent is additionally arranged at the end of the aorta covered stent, more stable supporting force is provided, expansion of a false cavity is helped to be reduced, and therefore the risk of Ia type and Ib type inner leakage is reduced; the positioning precision of the aorta covered stent can be improved, and postoperative complications can be reduced. The additional stent and aortic covered stent cross-connection installation connecting structure provides a solution for enhancing support and promoting vascular remodeling for a lesion area.

The invention discloses a nano composite hydrogel based on phase engineering 1T-MoSe2 as well as a preparation method and application of the nano composite hydrogel. The nano composite hydrogel comprises a temperature-sensitive hydrogel matrix, and the < 1 > T-MoSe2 nanosheets are dispersed in the hydrogel matrix. The hydrogel loaded with the 1T-MoSe2 nanosheets is used for preparing the medicine or dressing for treating the diabetic chronic wounds, the dressing can generate a large amount of ROS and generate the photothermal effect under the combined stimulation of exogenous ultrasound (US) and near-infrared light (NIR), and the hydrogel has efficient photothermal response and ROS generation capacity and can be used for preparing the medicine or dressing for treating the diabetic chronic wounds. Low-concentration hydrogen peroxide can be catalyzed to generate a large amount of hydroxyl radicals (. OH), and the broad-spectrum sterilization effect on various bacteria is achieved in combination with the photothermal effect; when no exogenous stimulation exists, inherent SOD and CAT-like enzyme activity is shown, excessive active oxygen is removed, the oxidative stress state of the wound surface is effectively relieved, polarization of macrophages to M2 anti-inflammatory phenotypes is promoted, and control over the inflammatory state is achieved.

The application provides application of a reagent for promoting expression of circular RNA circALSM1 in preparation of a drug for treating pulmonary arterial hypertension. The application verifies that an adeno-associated virus vector overexpressing circALSM1 can relieve disease progression of MCT-PAH rats and improve pulmonary vascular remodeling by constructing the adeno-associated virus vector, and provides a feasible strategy for preparation of a related targeted drug.

The invention relates to application of an NTSR1 inhibitor SR48692 in treatment of chronic sinusitis (CRS), in particular to application of the NTSR1 inhibitor SR48692 in treatment of chronic sinusitis (CRSwNP) accompanied with nasal polyp. Chronic sinusitis is a long-term inflammatory disease and is divided into a nasal polyp type and a nasal polyp-free type. By inhibiting a Wnt3a / beta-catenin signal channel, the SR48692 reduces abnormal deposition of an extracellular matrix and inhibits epithelial-mesenchymal transition (EMT), so that mucous membrane tissue remodeling is improved. Compared with a traditional treatment method, the SR48692 can reduce the recurrence rate of CRSwNP, provides a new treatment target for CRSwNP patients difficult to treat, and achieves a more lasting treatment effect.

This invention provides a collaborative control method based on consciousness impairment assessment and monitoring and synchronous neural stimulation. The method includes: an eye-tracking monitoring and analysis system extracting eye-tracking feature data from eye-tracking signals using image preprocessing and eye-tracking feature extraction algorithms; a server-side management system combining scale assessments and eye-tracking feature data, utilizing a multi-source data fusion assessment algorithm to output the patient's consciousness state assessment results and stimulation parameter information; a neural correlation electrical stimulator receiving the stimulation parameter information and using a timing synchronization control algorithm to synchronously initiate neural electrical stimulation with the eye-tracking monitoring and analysis system; and the server-side management system dynamically adjusting the consciousness state assessment results and stimulation parameter information based on post-stimulation eye-tracking response characteristics and stimulation parameter feedback, reusing the multi-source data fusion assessment algorithm to form a closed-loop control. This invention achieves timing synchronization and command closed-loop through a collaborative linkage algorithm, ensuring efficient collaborative operation of multiple modules and adapting to complex clinical scenarios such as ICUs and rehabilitation departments.

The invention relates to the technical field of biological medicines, in particular to combined application of FGF-2 and kavazinin C in preparation of a medicine for treating intrauterine adhesion. The invention provides an application of combination of FGF-2 (fibroblast growth factor 2) and kavazinin C in preparation of a medicine for treating intrauterine adhesion. The gel prepared from the FGF-2 and the kavazinin C has an excellent treatment effect on intrauterine adhesion, and can efficiently repair the shape and the function of the damaged uterus and recover the pregnancy ability.

This invention discloses an oxygen-catalyzing gel microsphere for regulating mitochondrial energy metabolism and its application in tissue repair. The microsphere comprises a calcium alginate hydrogel framework and multiple separate micro-reaction chambers embedded within the calcium alginate hydrogel framework. Each micro-reaction chamber independently contains ozone oil and graphene. This invention constructs a near-infrared responsive oxygen-catalyzing gel microsphere, achieving structured regulation of local oxygen supply and effective remodeling of cellular metabolic states. The system utilizes a dual-emulsion-microfluidic electrospray strategy to construct a spatially separated multi-chamber structure. Under near-infrared stimulation, the Gr-mediated photothermal-electronic synergy promotes the in-situ, efficient, and relatively mild conversion of ozone to oxygen, providing new insights for the design of hypoxia-related bone regeneration and other tissue repair materials.

The composite membrane comprises a membrane matrix formed by stable beta folding mutual crosslinking of fibroin and baicalin uniformly dispersed among fibroin molecular chain segments, the mass ratio of fibroin to baicalin is 100: 3-4, and the preparation method of the composite membrane comprises the following steps: 1) taking silkworm cocoons, dissolving and boiling the silkworm cocoons with a sodium carbonate solution for several times, washing the silkworm cocoons, and drying the silkworm cocoons to 60 DEG C; (2) dissolving with a ternary solution, centrifugally filtering to obtain fibroin clear liquid, and drying to obtain fibroin; (3) preparing a fibroin solution with the concentration of 1-30mg / ml from fibroin, and adjusting the pH value to 7.4; and 4) adding baicalin into the fibroin solution, drying after film formation, and annealing to obtain the composite film. The composite membrane has excellent biocompatibility, hemostasis performance and controllable biodegradability, and can promote M2 type polarization of macrophages, shorten the inflammation period and effectively promote skin wound healing.

The application discloses a new application of a substance increasing the content or activity of PARKIN in treating and / or preventing cardiovascular diseases. The application proves by transgenic and gene therapy means that increasing the content of PARKIN can significantly inhibit the activation of a cGAS-STING signal pathway and the downstream inflammatory response, thereby significantly improving the heart function, reducing the myocardial inflammatory response and myocardial fibrosis. The application provides a new drug target and treatment strategy for the prevention and treatment of cardiovascular diseases, and has important clinical application value.

This invention belongs to the fields of pharmaceutical formulation and biomedicine, and relates to an anti-atherosclerotic hybrid exosome, its preparation method, and its application. A hybrid composed of M2 macrophage exosomes and liposomes is used as a carrier, with the carrier loaded with a ferroptosis inhibitor and atorvastatin. The drug loading and encapsulation efficiency of the ferroptosis inhibitor are 1.55–2.57% and 11.99–49.86%, respectively; the drug loading and encapsulation efficiency of atorvastatin are 1.48–12.66% and 46.4–77.31%, respectively. The hybrid exosome provided by this invention has inflammatory targeting ability and higher stability, and can avoid the first-pass effect of the liver and the clearance of the circulatory system through intravenous injection. Simultaneously, this hybrid exosome has effects such as inhibiting ferroptosis, promoting cholesterol efflux, promoting cell burial, anti-inflammation, and regulating the immune microenvironment, enabling multi-faceted treatment of atherosclerosis, thus achieving better therapeutic effects.

The application discloses a kind of personalized dynamic rehabilitation man-machine interaction method and related equipment, obtain target parameter when target patient rehabilitation training;High-density flexible electrode is attached on the corresponding muscle of target patient's limb, surface electromyogram signal is collected, surface electromyogram signal time window is obtained and motor unit discharge pulse sequence is extracted therefrom;Surface electromyogram signal time window and motor unit discharge pulse sequence are respectively input into feature extraction module, and feature fusion is carried out by deep transform neural network, and the joint movement angle and end force of the patient are predicted by regression;The average discharge frequency of motor unit and the cumulative pulse per unit time are calculated, the active participation of target patient in the training process is quantified, the motion performance of the patient is evaluated and recorded according to the average absolute percentage error between the actual motion parameters and the target motion parameters of the patient;According to the active participation and motion performance of target patient, the parameters of rehabilitation robot are dynamically adjusted, and the rehabilitation initiative of patient is improved.

The present invention belongs to the technical field of pharmaceutical preparations, specifically a co-delivery liposome based on full-process regulation and its preparation method and application. The co-delivery liposome of the present invention is composed of an inorganic salt calcium phosphate nano core that can load genes and a liposome phospholipid bilayer with a small molecule drug embedded in the outer layer, and the drug is a histone deacetylase inhibitor propofol-docosahexaenoic acid, which is used for regulating the disordered microglia; the calcium phosphate nano core is loaded with a vascular endothelial growth factor C plasmid for transfection and expression of microglia; the liposome is modified with a selective galactose ligand that activates microglia, which is used for specific targeted activation of galectin-3 receptors on the surface of microglia, and cell selective targeting is achieved; the present invention can effectively regulate the function of inflammatory microglia, promote the generation of blood vessels and meningeal lymphatic vessels, protect cranial nerves and promote regeneration and recovery after TBI, and has good application prospects.

The invention relates to the technical field of biomedical materials, in particular to a 3D-printed self-power-generation hydrogel stent capable of promoting wound healing and a preparation method and application thereof.The 3D-printed self-power-generation hydrogel stent comprises an anode stent body and a cathode stent body, the anode stent body is prepared from hydrogel containing zinc, and the cathode stent body is prepared from hydrogel containing iron; the anode bracket further comprises a prepolymerization solution prepared from dopamine, ammonium persulfate, N, N '-methylene bisacrylamide, acrylamide and tetramethylethylenediamine; the hydrogel stent can be gradually degraded to release metal ions, so that the anti-inflammatory and vascularization effects are achieved; free radicals such as active oxygen and active nitrogen can be removed, and the anti-oxidation effect is achieved; voltage can be stably output for more than 7 days, expression of repair-promoting related genes is improved through stimulation of physiological micro-current, and proliferation and migration of fibroblasts are promoted; the scar-free healing of the wound within 16 days can be accelerated, and the application prospect is wide.

The invention relates to the technical field of pharmacy, in particular to an extracellular matrix imitating hydrogel loaded with nano bait, a preparation method and application. The bionic extracellular matrix hydrogel loaded with the nano bait comprises the nano bait and an extracellular matrix bionic hydrogel matrix. The nano bait (M1-NDs) is prepared from an M1 type macrophage membrane stimulated by lipopolysaccharide and interferon-gamma. In an inflammatory environment, the M1-NDs can selectively capture lipopolysaccharide and proinflammatory cytokines, so that NF-kappa B pathway activation is inhibited, and an inflammatory cascade reaction is relieved. The ECM bionic hydrogel prepared by taking collagen, hyaluronic acid and sodium alginate as raw materials is used as a carrier of M1-NDs, so that the biological activity of the nano bait can be effectively maintained, local slow release of the nano bait on a wound surface is realized, and meanwhile, collagen deposition, extracellular matrix remodeling and angiogenesis are promoted, so that the healing of an inflammatory wound surface is accelerated; the synergistic effect of anti-inflammation and tissue regeneration is realized.

The invention belongs to the technical field of medicines, discloses an oxa-evodiamine compound and a pharmaceutical application thereof, and particularly provides the oxa-evodiamine compound shown as a formula (I), and physiologically acceptable salts and pharmaceutical compositions thereof. The compounds can effectively inhibit proliferation of pulmonary artery smooth muscle cells caused by PDGF-BB, and can be used for preventing or treating pulmonary arterial hypertension. # imgabs0 #

The invention relates to the technical field of biomedical materials, and provides a dialdehyde polysaccharide biological cross-linking agent and a collagen cross-linking method thereof. The preparation method of the dialdehyde polysaccharide biological cross-linking agent comprises the following steps: S1, adding polysaccharide into molten imidazole, and heating and stirring to obtain a polysaccharide solution; adding acetylcysteine into the polysaccharide solution, stirring and mixing, and heating and reacting at 30-50 DEG C for 3-7 hours; s2, after the reaction is finished, adding ethanol to precipitate a product, then filtering and washing to remove unreacted substances, and then drying to obtain acetylcysteine modified polysaccharide; and S3, dispersing the acetylcysteine modified polysaccharide in a sodium periodate aqueous solution, uniformly stirring, reacting for 5-7 hours in a dark place at 30-50 DEG C, carrying out suction filtration after the reaction is finished to obtain a precipitation product, filtering, washing, and drying to obtain the acetylcysteine modified dialdehyde polysaccharide. The multifunctional group of acetylcysteine can react with multiple groups in polysaccharide molecules to form a uniform cross-linked network. The uniform cross-linked structure is beneficial to improving the physical properties and compatibility of the hydrogel.