Technology for building small-caliber vascular stent

A vascular stent and small-caliber technology, which is applied in the field of vascular stents, can solve the problems of poor compatibility of host endothelial cells, limited widespread use, and changes in hemodynamics, and achieves easy industrialization implementation, high industrialization value, and simple process. Effect

Inactive Publication Date: 2010-06-30
SHANGHAI P & P BIOTECH
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AI Technical Summary

Problems solved by technology

However, the biggest problem with such vascular substitutes is that they are poorly compatible with host endothelial cells, and it is difficult to spontaneously form endothelial cell lining on the inner surface; at the same time, they lack the compliance of natural arteries, which leads to changes in hemodynamics in blood vessels and subintimal hyperplasia
Therefore, the long-term patency rate after replacing small-caliber diseased arteries (such as coronary arteries, extremity arteries, etc.) and veins is very low; this limits its wide clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Electrospinning machine imported from Japan

[0015] The following steps are used to manufacture vascular stents:

[0016] 1. Manufacture of the inner wall of blood vessels: prepare A1 and B1 solutions respectively, mix equal amounts of A1 and B1 solutions within 2 minutes and pour them into the mold, take them out of the mold after 2 minutes, freeze-dry, and use 20-30KGY dose The gamma ray irradiation 24 hours sterilization is made; The described A1 solution comprises the fibrinogen that weight ratio is 6:1:0.1:18, carboxymethyl cellulose, aminopeptidase and glycerol; Described B1 solution Thrombin 2IU / ml, calcium chloride 4.4mg / ml.

[0017] 2. Electrospinning technology to construct the outer wall of the freeze-drying tube:

[0018] (1) Prepare utensils: weighing spoon (1), 100ml beaker (1), 100ml measuring cylinder (1), stirrer (1), 5mm diameter copper rod, and the above utensils are sterilized and depyrogenated for later use.

[0019] (2) Configuration solution: ...

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Abstract

The invention relates to a technology for building a small-caliber vascular stent, which comprises the following steps: (1) manufacturing the inner wall of a vessel with fibrin glue by a stent building technology, (2) building the outer wall of the vessel by an electrospinning technology and (3) drying, sterilizing and preserving the vascular stent. Compared with the prior art, the invention has the advantages of simple technology, convenient operation, easy implementation of industrialization and high industrialization value.

Description

technical field [0001] The invention relates to a blood vessel stent, in particular to a process for constructing a small diameter blood vessel stent. Background technique [0002] Currently, there are mainly three types of vascular stents used clinically: 1) autografted blood vessels such as internal mammary artery and great saphenous vein. Such blood vessels have no immune response, and the clinical effect of replacing diseased small-caliber arteries is very good, but the source is very limited. 2) Allograft blood vessels: derived from allografts. Due to the large immune rejection; it is difficult to effectively kill pathogenic microorganisms, and there is a possibility of infectious disease infection. Clinical use is rare. 3) Synthetic artificial blood vessel: It is prepared from polymeric organic materials (such as expanded polytetrafluoroethylene, polyester, polyurethane, etc.). This kind of material has good mechanical properties, and it can replace large and mediu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61L27/14
Inventor 何红兵
Owner SHANGHAI P & P BIOTECH
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