9 results about "Monodisperse droplets" patented technology

The invention discloses gallium ion imprinted amidoxime-based macroporous resin as well as a preparation method and application thereof, and belongs to the technical field of functional polymer materials and separation. The method comprises the following steps: pre-assembling a gallium trichloride template and monomers such as acrylonitrile, generating monodisperse liquid drops by utilizing a microfluidic technology, polymerizing by combining ultraviolet light, eluting the template by hydrochloric acid, and performing amidoximation modification by a hydroxylamine hydrochloride alkaline solution, thereby obtaining the resin. The resin is a monodisperse spherical microsphere, has a macroporous structure, has high selective recognition capability and high adsorption capacity on gallium ions, is fast in adsorption kinetics and good in regeneration performance, and is suitable for selectively separating or enriching gallium ions from a complex solution system.

This invention discloses a "cross"-shaped four-way parallel microfluidic emulsification system and its application, addressing the problems of difficult maintenance and poor product consistency during parallel scale-up of existing microfluidic emulsification technologies. The system includes a fluid drive and supply module, a fluid distribution module, and an emulsification module composed of multiple independent, detachable "cross"-shaped four-way microfluidic emulsification units connected in parallel. The key feature of each emulsification unit is that the microchannel diameters at the dispersed phase inlet and emulsion outlet are equal (dD=dE), and both are smaller than the microchannel diameter at the continuous phase inlet (dC). This design, combining modular structure and hierarchical flow distribution, significantly improves unit processing consistency, system maintainability, and flow uniformity during parallel scale-up, making it suitable for high-throughput preparation of monodisperse droplets and functional microspheres.

The invention belongs to the technical field of droplet jet printing, and relates to a multi-component droplet jet printing system and method. The device comprises a micro-fluidic base shell, a liquid drop generation module, a liquid drop detection module and a liquid drop sorting module, liquid in a plurality of parallel liquid channels is subjected to micro-fluidic mixing treatment through a micro-fluidic mixer, uniform mixed flow is obtained, the uniform mixed flow is treated through a continuous jet type micro-liquid drop generation method, and the liquid drop separation efficiency is improved. The continuous monodisperse liquid drops can be obtained, the continuous monodisperse liquid drops are detected through the liquid drop detection module, the continuous monodisperse liquid drops are processed through the liquid drop sorting module according to the detection result, non-printing target liquid drops can be subjected to directional deflection, and liquid drop sorting is completed. Through micro-fluidic mixing treatment, the component concentration proportion of the monodisperse liquid drops can be regulated and controlled online in real time, sorting and printing are carried out according to needs, and the device is suitable for the fields of pattern printing, electronic circuit printing, functional material screening, gradient biochemical reaction, additive manufacturing, biological manufacturing and the like.

This invention discloses a microcarrier for delivering active mitochondria, its preparation method, and its applications. The microcarrier comprises porous hydrogel microspheres, engineered mitochondria encapsulated within the microspheres, and a polydopamine coating on its surface. The engineered mitochondria are obtained by surface modification of active mitochondria with a polyamide-amine dendritic polymer modified with phenylboronic acid. The preparation method involves mixing the engineered mitochondria with a hydrogel prepolymer as the inner phase, preparing water-in-oil monodisperse droplets using microfluidic technology, curing them under ultraviolet light to obtain hydrogel microspheres, and then mixing them with a dopamine solution to form a polydopamine coating. This microcarrier effectively maintains mitochondrial activity and promotes cellular uptake, repairs damaged mitochondrial function, resists oxidative stress, and promotes cell proliferation, migration, and angiogenesis. Animal experiments show that this microcarrier significantly accelerates the healing of photodamaged skin wounds. This invention can be used to prepare drugs for treating skin wounds and has promising clinical applications.

The invention relates to the technical field of polymers, and provides polyetherketoneketone powder based on a microfluidic technology and a preparation method and device thereof, and the method comprises the following steps: taking a first liquid containing polyetherketoneketone as a dispersion phase, and taking a second liquid as a continuous phase; the solvent of the first liquid is a first solvent; the boiling point of the first solvent is higher than the melting point of the polyether ketone ketone; the second liquid and the first solvent are immiscible; the dispersed phase with the temperature of T1 and the continuous phase with the temperature of T2 enter the micro-fluidic chip, the dispersed phase is located in an inner phase channel of the micro-fluidic chip, the continuous phase is located in an outer phase channel of the micro-fluidic chip, the outer phase channel is concentrically arranged outside the inner phase channel in a sleeving mode, and the continuous phase is located in an inner phase channel of the micro-fluidic chip. The dispersed phase is sheared by the continuous phase to form monodispersed droplets. By means of the method, the high sphericity degree and the regular morphology of the powder can be guaranteed. The particle size and distribution of the powder can be accurately controlled by adjusting parameters such as two-phase flow velocity, viscosity, chip size and the like.

The invention provides devices that generate monodisperse droplets from a bulk liquid. The devices include a shearing mechanism, a holder for a vessel containing a liquid, and an optical system that transmit light to, and detects light from, liquid in the vessel. The invention also provides methods of using such devices to produce monodisperse droplets.

The invention belongs to the technical field of aerosol and fluid dynamics, and relates to a monodisperse fluorescent tracer micro-droplet-based instrument performance quantitative calibration method, which comprises the following steps of: marking a monodisperse droplet by using a fluorescent tracer agent; collecting and obtaining the total input amount of the marked monodisperse liquid drops entering the to-be-calibrated collecting device; extracting solutions containing fluorescent tracers and corresponding to the specific surfaces of the collecting device are obtained; and determining the collection efficiency and the inter-stage loss rate of each stage of the to-be-calibrated collection device. According to the invention, a standardized strict performance quantitative calibration method is provided for a collection device, especially a multistage fluid collection and separation device, by combining monodisperse fluorescence tracing micro-droplets with a standardized calibration process, so that the accuracy and consistency of core indexes such as capture efficiency, particle size separation precision and the like of the device are effectively guaranteed; the situation that the performance evaluation of the collecting device lacks a unified calibration standard is avoided, and meanwhile, real and accurate actual measurement data including the collecting efficiency of each stage and the inter-stage loss rate can be output.

This invention relates to a microfluidic monodisperse droplet generation device, method, and amplification reaction system, comprising a droplet generation component and a liquid storage tube. The droplet generation component has a liquid interface connected to the bottom end of the vertically positioned liquid storage tube. The liquid interface is connected to one end of a main liquid channel. The main liquid channel has multiple branch channels with a gradually expanding structure, the width of which gradually increases along the liquid flow direction. One end of each branch channel is connected to a liquid storage chamber, and the other end of the liquid storage chamber has a discharge channel. The height of the internal space of the liquid storage chamber is higher than the height of the branch channels, and the branch channels are connected to the lower part of the end of the liquid storage channel, so that a stepped structure is formed between the branch channels and the internal space of the liquid storage chamber. The generation device of this invention has a simple structure, low cost, and high portability.