A
system for regulating
blood pressure by stimulating an
afferent pathway to the brain which produces an
efferent output in kidneys includes a
electrode device adapted for implantation in the cervical region, a stimulator generator, a cable connecting the
electrode device and the stimulator generator, wherein the cervical region is generally located between a pair of common
carotid arteries, above an
aortic arch and in front of
cervical vertebrae C2 and C3. A method of implantation includes placing the
electrode device in the cervical region, selectively energizing the device in accordance with a stimulation scheme, assessing any changes in the patient's
blood pressure, selectively energizing the device in accordance with another stimulation scheme, and assessing any changes in the patient's blood, for determining an
optical stimulation scheme, wherein stimulation scheme involves parameters including, for example, position, placement and configuration of the electrode device in relation to surrounding tissue and / or organs, selection of electrodes energized, width, frequency and amplitude of stimulation current.