The invention discloses free mouse multi-brain-region optical genetic manipulation head-mounted equipment based on an
optical fiber array, and relates to the technical field of optical
genetics, the free mouse multi-brain-region optical genetic manipulation head-mounted equipment comprises a
skull fixing base, the
skull fixing base is fixed to the surface of a mouse
skull through
bone screws, and a
glass window is installed in the skull fixing base; according to the free mouse multi-brain-region optical genetic manipulation head-mounted device based on the
optical fiber array, the
signal output end of a
light source generator is inserted into a
signal input port, gaskets of different heights are selected to be matched with a limiting ring, the position of an
insertion core array is adjusted, and the output ends of a plurality of
insertion cores make contact with the upper surface of a
glass window; z-axis fine adjustment is achieved by replacing gaskets of different heights, it is ensured that the end face of the
ferrule is tightly attached to the surface of a
glass window, light loss and scattering are avoided, the
light spot positioning precision and the space consistency of stimulation depth are improved, the eight-channel
ferrule array supports simultaneous input of optical signals of different wavelengths or
modes, and multi-site and multi-parameter parallel optical genetic manipulation is achieved.