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Uterine cavity implant as well as preparation method and application thereof

A uterine cavity and object placement technology, which is applied in the field of preparation and animal-derived uterine cavity implants, can solve problems such as endometrial repair cannot be completed smoothly, menstrual flow does not increase significantly, uterine cavity re-adhesion, etc., to solve infertility problems, Effect of reducing scar formation, promoting growth and differentiation

Active Publication Date: 2017-08-18
BEIJING BIOSIS HEALING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, intrauterine adhesions may still occur after TCRA, and once intrauterine adhesions recur, endometrial repair will not be completed smoothly, and the clinical manifestations are no significant increase in menstrual flow or amenorrhea, so it is still necessary to take Certain anti-adhesion measures

Method used

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  • Uterine cavity implant as well as preparation method and application thereof
  • Uterine cavity implant as well as preparation method and application thereof
  • Uterine cavity implant as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0068] Figure 9 It is a schematic diagram of a uterine intrauterine implant according to an embodiment of the present invention. The uterine intrauterine implant is a bag-like structure with a roughly trapezoidal shape and at least part of the corners are arc-shaped. The opening 2 is located on the side of the shorter base of the trapezoid. It can be made by using one piece of small intestine submucosa matrix material that has been freeze-dried in vacuum and then folded in half, or by using two or more pieces of matrix material. The uterine intrauterine implant can be placed in the uterine cavity and unfolded, so as to isolate and protect the wound surface, promote the recovery of uterine cavity basement membrane and mucosa and other tissues, and prevent the occurrence of adhesions.

[0069] Further, the intrauterine intrauterine implant in the above embodiment may also include a supporting structure, so that the intrauterine intrauterine implant can be stretched inside the ...

Embodiment approach 2

[0073] Figure 10 It is a schematic diagram of an intrauterine implant according to another mode of the present invention. The uterine intrauterine implant 1 is a bag-like structure with a roughly triangular shape and at least part of the corners are arc-shaped. The opening 2 is located on one side of the triangle, and the length of the opening 2 is smaller than the length of the side, so that each end of the IUD 3 can be clamped at the end of the roughly triangular bag-shaped structure 1 . In the process of placing the intrauterine intrauterine device of this embodiment, the IUD 3 can be placed in the inner cavity of the intrauterine intrauterine object 1 in advance, and placed in the IUD placement device 4 together. Then make the IUD placement device 4 pass through the uterine ostium, and then make the uterine cavity built-in part break away from the IUD placement device and enter the uterine cavity. The intrauterine intrauterine implant 1 and the intrauterine device 3 tog...

Embodiment approach 3

[0075] Figure 11 It is a schematic diagram of an intrauterine implant according to another mode of the present invention. The uterine cavity implant 1 is a bag-like structure, and its shape is roughly round or oval. The opening 2 is located on a round face or a round edge of a circle or an ellipse. The IUD 3 and the intrauterine implant 1 can be placed in the uterine cavity by implementing 1 or 2 placement methods.

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Abstract

The invention relates to a uterine cavity implant as well as a preparation method and application thereof. The uterine cavity implant is characterized by having a bagged structure. The uterine cavity implant comprises a substrate material of animal small intestine submucosa subjected to decellularization treatment. An implantable medical device for preventing and treating intrauterine adhesion comprises a biological tissue substrate material. The present decellularization technology for a biological repairing material is improved; compared with the present product, the biological tissue substrate material provided by the invention has the advantages of lower DNA residual quantity, lower immunogenicity, higher anti-infection capacity and higher repairing capacity; and the uterine cavity implant is beneficial to the recovering of tissues, such as, uterine cavity base layer, submucosa and mucous layer. Besides, the invention prepares the biological repairing material into the uterine cavity built-in structure which is used for isolating wound surfaces, repairing uterine cavity tissues and reducing scar forming, so that the intrauterine adhesion problem is solved, and the accordingly generated sterility problem also can be solved.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to an intrauterine implant of animal origin, a preparation method and use thereof. The intrauterine intrauterine implant is an animal-derived material, and is used for treating and preventing intrauterine adhesions. Background technique [0002] Endometrium refers to the layer that forms the lining of the mammalian uterus. The endometrium is divided into three layers: dense layer, spongy layer and basal layer. 2 / 3 of the surface of the inner membrane is dense layer and spongy layer, collectively referred to as the functional layer, which undergoes periodic changes and falls off under the influence of ovarian sex hormones. The basal layer is the 1 / 3 endometrium close to the myometrium, rich in blood vessels, unaffected by ovarian sex hormones, and does not undergo periodic changes. [0003] Clinically, when there is trauma on the inner wall of the uterus, such as uter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00A61L31/04A61L31/14
CPCA61L31/005A61L31/046A61L31/14C08L89/00
Inventor 赵博王洪权夏磊磊赵延瑞李学军张晋辉
Owner BEIJING BIOSIS HEALING BIOLOGICAL TECH
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