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Preparation method of polyurethane/small intestine submucosa composite material

A small intestinal submucosa and composite material technology, applied in medical science, prosthesis, etc., can solve the problems of single performance and application limitations of soft tissue defect repair materials, achieve uniform and controllable mechanical properties, promote regeneration and repair, and excellent The effect of mechanical properties

Active Publication Date: 2015-02-11
睿博欣源(成都)生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide the preparation method of polyurethane / small intestinal submucosa (PU / SIS) composite material, the composite material prepared has the excellent performance of polyurethane and SIS at the same time, has not only good rebound performance, mechanical property, but also has biological Activity, biocompatibility, can induce and promote the regeneration and repair of tissue structures, overcome the defects of existing soft tissue defect repair materials that only have a single performance and limited applications

Method used

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  • Preparation method of polyurethane/small intestine submucosa composite material
  • Preparation method of polyurethane/small intestine submucosa composite material
  • Preparation method of polyurethane/small intestine submucosa composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Embodiment 1 The present invention prepares the method for PU / SIS composite material

[0084] 1. Preparation of anionic water-based polyurethane emulsion

[0085] 1) Prepolymerization: Add isophorone diisocyanate (IPDI) and polytetrahydrofuran 1000 (PTMG1000) with a molar ratio of 1.45:0.5, in which isophorone diisocyanate is 0.1mol, into a three-necked bottle, and add 0.2ml Stannous octoate catalyst, pre-polymerized at 74°C for 2h50min;

[0086] 2) Chain extension: 2,2-dimethylolbutyric acid (DMBA) with a PTMG1000 / DMBA molar ratio of 5:5 was reacted at 54° C. for 3 h. Observe the viscosity of the system during the reaction process. If necessary, add an appropriate amount of acetone to adjust the viscosity of the reaction system. Visually observe the viscosity of the reaction system that does not accumulate on the stirring rod during the stirring process, so that the reaction can be maintained in a stable state;

[0087] 3) Neutralization and emulsification: at room t...

Embodiment 2

[0108] Embodiment 2 The present invention prepares the method for PU / SIS composite material

[0109] 1. Preparation of anionic water-based polyurethane emulsion

[0110] 1) Prepolymerization: Add isophorone diisocyanate (IPDI) and polytetrahydrofuran 1000 (PTMG1000) with a molar ratio of 1.45:0.5, in which isophorone diisocyanate is 0.1mol, into a three-necked bottle, and add 0.2ml Stannous octoate catalyst, prepolymerized at 74°C for 2h50min;

[0111] 2) Chain extension: 2,2-dimethylolpropionic acid (DMPA) with a PTMG1000 / DMBA molar ratio of 5:5 was reacted at 54° C. for 3 h. Observe the viscosity of the system during the reaction process. If necessary, add an appropriate amount of acetone to adjust the viscosity of the reaction system. Visually observe the viscosity of the reaction system that does not accumulate on the stirring rod during the stirring process, so that the reaction can be maintained in a stable state;

[0112] 3) Neutralization and emulsification: at room te...

Embodiment 3

[0124] Embodiment 3 The present invention prepares the method for PU / SIS composite material

[0125] 1. Preparation of anionic water-based polyurethane emulsion

[0126] Same as Example 2.

[0127] 2. Preparation of SIS powder

[0128] Same as Example 1.

[0129] 3. Preparation and molding of PU / SIS composite materials

[0130] 1) Preparation: 0.3 g of SIS powder was added to 10 g of polyurethane emulsion with a solid content of 21%, and stirred at room temperature for 3 hours to obtain a polyurethane / SIS sol.

[0131] 2) Forming: Pour the sol into a 24-well plate, pre-freeze at -40°C, and vacuum freeze-dry to form.

[0132] 3) Cross-linking: Soak the obtained material in 2.5% (w / v) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride at a pH of 5.5 for twice the volume of the material (EDC), after cross-linking at room temperature for 36 h, washed with saturated brine three times to remove residual EDC. Wash the material with a large amount of deionized water, fr...

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Abstract

The invention discloses a preparation method of a polyurethane / small intestine submucosa composite material, which comprises the following steps: a. evenly mixing an anionic water-based polyurethane emulsion and small intestine submucosa, and carrying out vacuum freeze-drying to form, wherein the small intestine submucosa is 0.01-0.03 time of the polyurethane emulsion (w / w), the average particle diameter of the polyurethane emulsion is 15.18-42.86nm, and the solid content is 3-21%; and b. crosslinking, and carrying out vacuum freeze-drying. The composite material prepared by the method has favorable properties of the polyurethane and SIS (styrene-isoprene-styrene), has the advantages of favorable resilience, favorable mechanical properties, favorable bioactivity and favorable biocompatibility, can induce and promote the regeneration restoration of the tissue structure, overcomes the defect that the existing soft tissue defect restoration material only has the properties in a single aspect and is limited in application, and has favorable application prospects.

Description

technical field [0001] The invention relates to a preparation method of polyurethane / small intestinal submucosa composite material. Background technique [0002] An ideal soft tissue repair material should have the following properties: (1) biocompatibility, such as cell compatibility, tissue compatibility, etc.; (2) excellent mechanical properties, such as tensile strength, resilience, etc. In addition, soft tissue repair materials also need a suitable three-dimensional porous structure, which is conducive to the growth and differentiation of cells, tissue regeneration and the delivery of nutrients. [0003] At present, there are two main categories of soft tissue repair materials: (1) synthetic polymer materials, such as polyurethane, which have excellent physical and mechanical properties, but do not have biological activity and cannot promote tissue regeneration; (2) natural extracellular matrix ( extracellular matrix (ECM), such as collagen, gelatin, small intestinal s...

Claims

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Application Information

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IPC IPC(8): C08J9/28C08J3/24C08L75/08C08L89/00C08G18/66C08G18/48C08G18/34C08G18/32C08G18/10A61L27/44A61L27/56A61L27/50
Inventor 解慧琪龚梅笪琳萃
Owner 睿博欣源(成都)生物科技有限责任公司
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