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Host-guest supramolecular hydrogel induced by visible light in situ polymerization and preparation method and application thereof

A supramolecular hydrogel, in-situ polymerization technology, applied in the direction of prosthesis, medical science, tissue regeneration, etc., can solve the problem of low strength and modulus, and achieve the effect of not easy to fall off, tight bonding and strong interaction force

Inactive Publication Date: 2021-03-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Natural polymers are often used to prepare hydrogel tissue engineering scaffolds due to their good biocompatibility, but their strength and modulus are usually not high

Method used

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  • Host-guest supramolecular hydrogel induced by visible light in situ polymerization and preparation method and application thereof
  • Host-guest supramolecular hydrogel induced by visible light in situ polymerization and preparation method and application thereof
  • Host-guest supramolecular hydrogel induced by visible light in situ polymerization and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve 0.1 g of gelatin and 0.2 g of Ac-β-CD in deionized water, add 0.0004 g of riboflavin and 0.02 g of L-arginine, and vortex to prepare a mixed gel precursor solution. The gel precursor solution was applied to the surface of the chicken heart with a 3D printed brush, and irradiated with 450nm blue light for 5 minutes to prepare the host-guest supramolecular hydrogel patch.

Embodiment 2

[0024] Dissolve 0.1 g of gelatin and 0.25 g of Ac-β-CD in deionized water, add 0.0005 g of riboflavin and 0.025 g of L-arginine, and vortex to prepare a mixed gel precursor solution. The gel precursor solution was applied to the surface of the chicken heart with a 3D printed brush, and irradiated with 450nm blue light for 5 minutes to prepare the host-guest supramolecular hydrogel patch.

Embodiment 3

[0026] Dissolve 0.1 g of gelatin and 0.3 g of Ac-β-CD in deionized water, add 0.0006 g of riboflavin and 0.03 g of L-arginine, and vortex to prepare a mixed gel precursor solution. The gel precursor solution was applied to the surface of the chicken heart with a 3D printed brush, and irradiated with 450nm blue light for 5 minutes to prepare the host-guest supramolecular hydrogel patch.

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Abstract

The invention discloses a host-guest supramolecular hydrogel patch induced by visible light in situ polymerization and a preparation method and an application thereof. The preparation method comprisesthe following steps of: dissolving gelatin and acryloyl cyclodextrin (Ac-beta-CD) into water according to a certain mass fraction, and adding a certain amount of visible light initiator (riboflavin and L-arginine) to prepare a gel precursor solution; and then coating the myocardial surface with the gel precursor solution, and initiating in-situ gelling under visible light with a certain wavelength. The hydrogel myocardial patch induced by visible light in situ polymerization has proper mechanical strength, is tightly combined with tissues, and can be completely degraded after being stored ina PBS solution (containing type I collagenase) at 37 DEG C for 28 days.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a host-guest supramolecular hydrogel induced by visible light in situ polymerization and its preparation method and application, specifically gelatin and acryloyl cyclodextrin are combined through hydrophobic host-guest interaction , and trigger double bond polymerization on cyclodextrin under visible light to form hydrogel cardiac patch in situ. Background technique [0002] Natural polymers are often used to prepare hydrogel tissue engineering scaffolds due to their good biocompatibility, but their strength and modulus are usually not high. Chemically cross-linked hydrogels are usually difficult to degrade due to their relatively stable internal cross-linked structure, and it is often difficult for host cells to penetrate into the interior of the gel after transplantation into the body. [0003] Gelatin is a partially degraded product of collagen, and it has RGD poly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/16C08L89/00A61L27/22A61L27/20A61L27/50A61L27/58A61L27/52
CPCA61L27/20A61L27/222A61L27/50A61L27/52A61L27/58A61L2430/20C08J3/075C08J3/246C08J2305/16C08J2489/00C08L5/16
Inventor 刘文广肖萌杨建海
Owner TIANJIN UNIV
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