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Compound wound dressing with tissue binding performance and preparation method of compound wound dressing

A composition and composite hydrogel technology, applied in bandages, medical science, etc., can solve the problems of too fast gelation, unfavorable clinical use of skin wound dressings, etc., and achieve the effect of promoting angiogenesis and wound healing process

Active Publication Date: 2018-08-17
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Chinese patent CN105521521A discloses a medical gel for lung sealing and its preparation method and application, and mentions the application of human serum albumin and a hydrophilic polymer (preferably polyethylene glycol) containing Rapid response under severe conditions is used for wound adhesion, hemostasis, anti-leakage or anti-adhesion surgery, but the gelation time of this gel is 3 to 150 seconds, and the gelation is too fast, which is not conducive to skin wounds. Clinical use of dressings

Method used

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  • Compound wound dressing with tissue binding performance and preparation method of compound wound dressing
  • Compound wound dressing with tissue binding performance and preparation method of compound wound dressing
  • Compound wound dressing with tissue binding performance and preparation method of compound wound dressing

Examples

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Effect test

Embodiment 1

[0067] Prepare a phosphate buffer solution with a pH of 7.4, add human serum albumin powder (purchased from Sichuan Yuanda Shuyang Pharmaceutical Co., Ltd.) to dissolve and prepare a transparent liquid with a mass fraction of 20%. The dissuccinimide succinate-based polyethylene glycol powder with a molecular weight of 3500 (purchased from Beijing Jiankai Technology Co., Ltd.) was dissolved in deionized water to prepare an aqueous solution with a mass fraction of 10%. Change the chemical composition to CaO 24.5%, SiO 2 45%, Na 2 O 24.5%, P 2 o 5 6%, 45S5 bioactive glass powder with a particle size of less than 100 microns (purchased from Kunshan Huaqiao Technology New Material Co., Ltd.) was added to the phosphate buffer solution of albumin, and the mass fractions were 0.10%, 0.50%, and 1.00% respectively , 2.00%, mix well. After that, the phosphate buffer solution of albumin added with 45S5 and the aqueous solution of double succinimide succinate-based polyethylene glyco...

Embodiment 2

[0069]To prepare a phosphate buffer solution with a pH of 7.4, weigh 0.25 g of human serum albumin powder and dissolve it in 0.75 ml of phosphate buffer solution, then add 0.01 g of 45S5 bioactive glass powder with a particle size of 10 microns and mix well. Dissolve 0.1 gram of disuccinimidyl succinate-based polyethylene glycol powder with a molecular weight of 3500 in 1 ml of deionized water. The two solutions were mixed with a gelation time of 1 minute and 20 seconds to obtain a 0.50% bioactive glass / albumin hydrogel.

[0070] After testing, the tissue bonding strength of the 0.50% bioactive glass / albumin hydrogel is 81.29kPa (as image 3 (A), (B), (D) shown in), the compressive strength is 265.26kPa (such as image 3 (C) in ), and can continuously release Ca and Si bioactive ions (such as Figure 4 shown).

Embodiment 3

[0072] The chronic wound model on the back of nude mice was used to evaluate the wound repair effect of the invented hydrogel. The specific method is to create a wound with a diameter of 1 cm on the back of the nude mouse, and inject depomedrol intravenously to delay the healing. The albumin-based hydrogel and 0.5% bioactive glass / albumin hydrogel in Example 2 were evenly spread on the wound. Results from tissue staining (eg Figure 5 shown), it can be seen that after 7 days, the wounds on the back of nude mice in the 0.5% bioactive glass / albumin hydrogel group were obviously repaired, and there was obvious angiogenesis.

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Abstract

The invention provides a compound wound dressing with tissue binding performance and a preparation method of the compound wound dressing. Bioactive glass / albumin composite hydrogel at least comprisesbioactive glass, albumin, polyethylene glycol containing an electrophilic functional group and buffer solution, pH (potential of hydrogen) of the buffer solution ranges from 5.0 to 8.0, and the raw materials are mixed into gel to obtain the composite hydrogel. The composite hydrogel comprises albumin hydrogel and the bioactive glass loaded into the albumin hydrogel, the content of the albumin hydrogel is 95% or more, and the content of the bioactive glass is 5% or less.

Description

technical field [0001] The invention belongs to the fields of biomedicine, material technology, wound repair and medical equipment, and specifically relates to a bioactive glass in-situ activated albumin composite medical hydrogel, and the invention also relates to the preparation method and application of the composite hydrogel material . Background technique [0002] The skin is the largest organ of the human body, and its main function is to isolate the body tissue from the external environment, thereby playing a role of protection and shielding. However, skin injuries caused by trauma, burns, scalds, metabolic diseases (such as diabetes, etc.) and aging are very common in clinical practice. [0003] The key to treating skin defects is to heal the wound as soon as possible. Wound healing can be divided into three stages according to time: 1. Inflammatory stage. It has been reported in the literature that early inflammation is beneficial to the occurrence of angiogenesi...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/008A61L26/009A61L26/0095A61L2300/102A61L2300/412A61L2300/604C08L71/02C08L89/00
Inventor 常江周艳玲
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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