17 results about "D-alpha-Tocopheryl Acetate" patented technology

The invention discloses a resource utilization method of low-quality C15 phosphonium salt. The preparation method comprises the following steps: (1) performing thermal decomposition reaction and isomerization reaction on the low-quality phosphonium salt to generate the C15 phosphonium salt; (2) adding a solvent into the reaction liquid obtained in the step (1) for extraction and phase separation, and collecting a product phase containing a C15 phosphine salt isomer; and (3) adding pentacaraldehyde and carbonate into the product phase containing the phosphonium salt, and carrying out condensation reaction to prepare the vitamin A acetate. According to the method, the low-quality phosphonium salt generated in the C15 phosphonium salt production process can be recycled, the produced low-grade vitamin A acetate is sold, the product mark is enriched, and the industrial competitiveness of the product is improved. The process is simple to operate, mild in reaction condition, green and environment-friendly, free of waste liquid and suitable for industrial production, and the industrial chain cost of the vitamin A acetate is greatly reduced.

The invention belongs to the technical field of pet nutrition, and discloses a trace element composite additive for improving the reproductive performance of pets, which comprises the following raw materials: zinc sulfate, sodium selenite, copper sulfate, manganese sulfate, vitamin E acetate, L-lysine hydrochloride, taurine, methionine, selenium yeast and zeolite powder. The zeolite powder is subjected to a specific acid treatment activation process, so that the adsorbability and the stability are improved. The invention also discloses a preparation method of the additive. A three-step mixing process is adopted to ensure the uniformity of the product. The additive is suitable for being added into feed in the breeding period of canine or feline pets, the adding amount of the additive is 0.1-0.5% of the total weight of the feed, and the feeding time is 1 month before breeding and 1 month after breeding. Through scientific proportioning of organic trace elements and inorganic trace elements, in combination with specific amino acids and vitamins, the components have a synergistic effect, so that the pregnancy rate, the litter size and the survival rate of newborn animals of pets are remarkably increased, and meanwhile, the pet feed has good storage stability and use safety.

The application discloses a waterproof makeup composition in the field of cosmetics and a preparation method thereof. The composition comprises a self-repairing organic silicon polyurethane elastomer, double-hydrophobic modified nano silicon dioxide, cyclopentasiloxane, red iron oxide, hydroxyethyl cellulose, polyglyceryl isostearate, sodium hyaluronate, phenoxyethanol, vitamin E acetate and deionized water. The preparation process comprises the following steps: dissolving the self-repairing organic silicon polyurethane elastomer in cyclopentasiloxane to form an oil phase; dissolving hydroxyethyl cellulose in water and then adding other components to form an aqueous phase; mixing and emulsifying the two phases, adding double-hydrophobic modified nano silicon dioxide and other components for grinding, and finally adjusting the pH value. The composition has excellent waterproof performance, long-lasting makeup effect and self-repairing function, and has good skin compatibility.

The invention belongs to the technical field of nano packaging, and relates to embedding of protein nanoparticles on vitamins, in particular to a method for embedding vitamin acetate with prolamin. Dissolving prolamin and vitamin acetate in glacial acetic acid to obtain a glacial acetic acid phase; dissolving a stabilizer in water to prepare a stabilizer phase; adding the stabilizer phase into the glacial acetic acid phase, and uniformly mixing to obtain a mixed solution; the volume of the stabilizer phase is lower than that of the glacial acetic acid phase; adding the mixed solution into water, and mixing to form the vitamin acetate-loaded prolamin particles wrapped by the stabilizer; the volume of the mixed liquid is lower than that of the water. According to the method provided by the invention, the embedding rate of the prolamin on the vitamin acetate can be improved, the release rate is slowed down, and the stability of the storage process is enhanced.

The present invention relates to the field of veterinary vaccinology, specifically combination vaccines for swine. In particular, the present invention relates to a combination vaccine for protection against infection with the pathogens porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae (Mhyo), comprising a non-replicating immunogen for PCV2 and a non-replicating immunogen for Mhyo. The vaccine is characterized in that it is an oil-in-water emulsion comprising squalane, vitamin E acetate, and silica. In another embodiment, the present invention relates to a combination vaccine for protection against infection with the pathogens PCV2 and Mhyo by intradermal administration.

The invention relates to the technical field of veterinary medicines, in particular to a vitamin ADE injection for cattle and a preparation method thereof. Every 10 L of the vitamin ADE injection for the cattle is prepared from the following components: 500 to 600 g of vitamin A palmitate, 2 to 3 g of vitamin D3, 2800 to 3200 g of vitamin E acetate, 10 to 20 g of butylated hydroxytoluene, 1800 to 2200 g of absolute ethyl alcohol, 180 to 220 g of analgesic, 250 to 350 g of solubilizer, 150 to 250 g of stable synergist and the balance of isopropyl myristate. According to the invention, hydrogenated palm oil glyceride, ethylene oxide, succinic anhydride, ascorbyl palmitate and the like are used as raw materials, and the stable synergist with the following effects is prepared through related chemical reactions, and the prepared stable synergist integrates the functions of solubilization, oxidation resistance and stimulation reduction; as a raw material of the injection, the oxidation resistance and the stability of the injection are effectively improved; the injection prepared by the invention is clear and transparent, has excellent stability, can effectively relieve injection pain and tissue stimulation, and remarkably improves the safety, stability and clinical applicability of the injection.

To provide combination vaccines for swine.SOLUTION: Provided is a combination vaccine for protection against a pathogenic infection with porcine circo virus type 2 (PCV2) and Mycoplasma hyopneumoniae (Mhyo) comprising non-replicating immunogen of PCV2 and non-replicating immunogen of Mhyo. The vaccine is characterized in that it is an oil-in-water emulsion comprising squalane, vitamin E-acetate and silica. In another embodiment, the invention provides a combination vaccine for protection against a pathogenic infection with PCV2 and Mhyo by intradermal administration.SELECTED DRAWING: None

The invention discloses a waterproof cosmetic composition and a preparation method thereof in the field of cosmetics. The composition is prepared from a self-repairing organic silicon polyurethane elastomer, double-hydrophobic modified nano silicon dioxide, cyclopentasiloxane, iron oxide red, hydroxyethyl cellulose, polyglycerol isostearate, sodium hyaluronate, phenoxyethanol, vitamin E acetate and deionized water. The preparation method comprises the following steps: dissolving the self-repairing organic silicon polyurethane elastomer in cyclopentasiloxane to form an oil phase; dissolving hydroxyethyl cellulose in water, and adding other components to form a water phase; after mixing and emulsifying the two phases, adding components such as double-hydrophobic modified nano silicon dioxide and the like, grinding, and finally adjusting the pH value. The composition has excellent waterproof performance, lasting makeup effect and self-repairing function, and also has good skin compatibility.

The invention provides electrolyte-containing coffee as well as a preparation method and application thereof, and belongs to the technical field of coffee beverages. According to the invention, only components such as coffee concentrate, instant coffee powder, erythritol, potassium citrate, sodium citrate, vitamin B3, vitamin B6, synthetic vitamin E acetate dry powder, grapefruit concentrated juice, purified water and the like are adopted, and preservatives or additives such as dipotassium phosphate and the like are not used. The black coffee liquid, the electrolyte and the grapefruit concentrated juice are effectively combined, so that absorption of intestinal tracts to lipid can be inhibited, generation of stimulated bile acid is reduced, the risk of gastric mucosa damage is reduced, the content of triglyceride and cholesterol in excrement is increased, accumulation of fat in bodies is reduced, and weight rise of high-fat diet mice can be effectively relieved.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses an anti-schizophrenia lyotropic liquid crystal long-acting injection and a preparation method and application thereof, and the anti-schizophrenia lyotropic liquid crystal long-acting injection is composed of an anti-schizophrenia drug, an amphiphilic compound and an organic solvent; the anti-schizophrenia medicine is selected from any one of brexpiprazole, cariprazine and aripiprazole; the amphiphilic compound is selected from any one or more of soybean phosphatidylcholine, egg yolk phosphatidylcholine, glyceryl monooleate, glyceryl monopalmitate, glyceryl dioleate, glyceryl trioleate, vitamin E acetate and phytantriol; the organic solvent is selected from one or more of ethanol, N-methyl pyrrolidone, dimethyl sulfoxide and 1, 2-propylene glycol. The anti-schizophrenia lyotropic liquid crystal in-situ gel long-acting injection forms a stable semi-solid drug reservoir through solvent exchange after administration so as to play a therapeutic effect in long-acting treatment of positive schizophrenia and negative schizophrenia and prevention of schizophrenia relapse.

The invention discloses an immobilized enzyme reaction application, and particularly relates to a method for catalytically synthesizing vitamin A palmitate in a solvent-free system by utilizing immobilized lipase. Through molecular modification, the specific enzyme activity of the lipase double mutant AF-R296P / L330S is maximally improved by 9.47 times, and under the condition that no other solvent is added, the reaction can still be carried out by taking molten methyl palmitate as a catalytic medium. The immobilized lipase is prepared by using the lipase mutant with improved activity and taking macroporous adsorption resin as a carrier, can efficiently catalyze vitamin A acetate and methyl palmitate to generate the vitamin A palmitate, and has a good application prospect in the production of the vitamin A palmitate.

The invention provides a preparation method of a hydrolysis inhibitor cyclohexane-1, 2-dicarboxaldehyde, which comprises the following steps: adding cyclohexane-1, 2-dicarboxaldehyde as a hydrolysis inhibitor into a lewis acid and protonic acid catalytic system to avoid hydrolysis of trimethylhydroquinone diester, so that in a reaction for preparing vitamin E acetate by using trimethylhydroquinone diester as a raw material, the yield of vitamin E acetate is increased, and the yield of vitamin E acetate is increased. No vitamin E intermediate is generated, and the vitamin E acetate can be obtained through high-yield conversion without further addition of an acylation reagent. According to the method, low-concentration cyclohexane-1, 2-dicarboxaldehyde is added as a hydrolysis inhibitor, the hydrolysis inhibition efficiency reaches 99% or above, meanwhile, a reaction system for generating vitamin E acetate by catalyzing trimethylhydroquinone diester through lewis acid and protonic acid is not affected, vitamin E acetate can be generated in one step, introduction of an acylation reagent is avoided, and the method is suitable for industrial production. And the preparation process flow of the vitamin E acetate is simplified.

The invention belongs to the technical field of vitamin preparations, and particularly relates to a vitamin A microcapsule preparation and a preparation method thereof.The vitamin A microcapsule preparation is prepared from, by weight, 40-60 parts of vitamin A acetate crystals, 160-200 parts of gelatin, 10-15 parts of xanthan gum and a proper amount of water, the gelatin is used as a main embedding material, the xanthan gum is used as a stabilizer, the water is used as a dispersion medium, and the dosage of the water is used for adjusting the viscosity of the emulsion formed by the components to 1200-1500cp; the emulsion is high in stability, the viscosity of the emulsion is adaptive to spray drying, the final product can keep high activity under normal-temperature and high-temperature conditions, the formula is reasonable, and the preparation process is simple.

The invention discloses amoxicillin sodium and clavulanate potassium for injection and a preparation method of the amoxicillin sodium and clavulanate potassium, and relates to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: adding vitamin E acetate and poloxamer 124 into absolute ethyl alcohol, and uniformly mixing to obtain a mixed solution A; adding amoxicillin sodium and potassium clavulanate into the mixed solution, and uniformly mixing to obtain a mixed solution B; and adding the mixed solution B into a spray dryer, and carrying out spray drying in an inert dry atmosphere to obtain the amoxicillin sodium and clavulanate potassium powder. Vitamin E acetate and poloxamer 124 are added into medicine molecules, and the inlet and outlet temperatures are controlled in cooperation with a spray drying process, so that the amoxicillin sodium and clavulanate potassium powder is obtained. The stability of amoxicillin sodium and clavulanate potassium for injection can be effectively improved.

The invention belongs to the technical field of gene engineering of enzymes, and particularly relates to lipase as well as preparation and application thereof. The wild type lipase TWG5L coding gene from Tilletia walkeri is obtained through whole gene synthesis, and the wild type lipase and the coding gene twg5l of the wild type lipase are obtained. A wild type lipase gene is modified by using a key site amino acid residue site-directed mutagenesis technology to obtain a lipase mutant TWG5LN87Y and an encoding gene twg5l2 thereof, recombinant plasmids are constructed, high-efficiency expression of the lipase mutant TWG5LN87Y in pichia pastoris is realized, and the relative enzyme activity of the mutant is 299% of that of the wild type. The lipase mutant catalyzes vitamin A acetate and palmitic acid to generate vitamin A palmitate, the yield of the lipase mutant is 190% of that of a wild type, and the lipase mutant has important industrial value.

This invention discloses a squalane lip essence oil and its preparation process, comprising the following raw material components: Phase A: tridecyl trimellitate; diisostearyl malate; ethylhexyl palmitate; 972 hydrogen powder; Phase B: glyceryl behenate / eicosadecanate; polyisobutylene; Phase C: hydrogenated (styrene / isoprene) copolymer / pentaerythritol tetra(bis-tert-butylhydroxyhydrogenated cinnamic acid) ester; plant squalane; camellia seed oil; shea butter; avocado oil; baobab oil; comfrey oil; vitamin E acetate; Phase D: pigment; The lip essence oil of this invention can significantly moisturize and nourish, and has repairing, anti-inflammatory and soothing effects on the lip skin.

The invention discloses a soothing and repairing mask and a preparation method thereof, and belongs to the technical field of cosmetics. Chlorosulfonic acid and chitosan are mixed, stirred and reacted to obtain sulfonated chitosan; mixing the sulfonated chitosan, zinc sulfate and a sodium tripolyphosphate solution, stirring and reacting to obtain complexed chitosan; mixing the complexed chitosan, silk fibroin and laccase, stirring and reacting to obtain a modified chitosan complex; mixing and stirring the modified chitosan complex, the modified pullulan polysaccharide compound and sodium alginate to obtain a soothing and repairing compound; hydroxyethyl cellulose, xanthan gum, glycerin, 1, 3-propylene glycol, allantoin, disodium ethylene diamine tetraacetate, a repairing and relieving compound, a centella asiatica extract, panthenol, sodium hyaluronate, vitamin E acetate, ceramide 3B, 1, 2-hexanediol, caprylyl glycol, ethylhexylglycerin and deionized water are mixed and stirred, and mask essence is obtained; cleaning and dehydrating the mask base cloth, and soaking the mask base cloth into the mask essence to obtain the soothing and repairing mask.