The invention relates to a sharkskin lotus leaf imitation nano low resistance antifouling self-cleaning antiseize waterproof paint. The technical scheme of the invention includes that the paint is composed by the following components by parts by weight: 65-99 parts of component A containing 40-60 parts of hydroxyl acrylic resin, 20-25 parts of pigment, 3-5 parts of assistant and 20-30 parts of solvent, 1-35 parts of component B containing 1-35 parts of oxy-silicane and 1-5 parts of nano material silicone dioxide, and 5-25 parts of component C containing 5-35 parts of biuret or tripolymer; through crosslinking and solidifying of hydroxyl acrylic resin and oxy-silicane glue and biuret or tripolyme, the surface of formed paint film has extremely low friction coefficient the same as sharkskin and lotus leaf and extremely low surface energy, shows extremely good low resistance, antifouling, self-cleaning, antiseize waterproof properties and excellent mechanical strength, adhesion, acid-base resistance, temperature change resistance, weather ability and ageing resistance, is environmentally friendly and non-toxic and does not pollute marine environment. The invention can be widely applied to the building, home appliance, electricity and traffic fields, is energy-saving and environmentally friendly and fills the gap in the field.