58 results about "Calcium borogluconate" patented technology

The invention relates to the technical field of preparation of cured beef, and discloses low-salt cured beef which comprises main materials and auxiliary materials in parts by mass as preparation raw materials, the main materials comprise fresh yellow cattle meat and compound salt, and the auxiliary materials comprise tea polyphenol, alanine, calcium gluconate and a kelp powder aqueous extract. The formula comprises 100 parts of fresh yellow cattle meat, 5 parts of compound salt, 0.1 part of tea polyphenol, 0.2 part of alanine, 0.5 part of calcium gluconate and 1 part of kelp powder aqueous extract. The method comprises the following steps: putting cleaned beef strips into a microwave oven, mixing 5% of compound salt with tea polyphenol, anthocyanin, rosemary extract, alanine and calcium gluconate in order to improve the pickling efficiency, adding 50 parts of clear water, and uniformly stirring to prepare a pickling solution; and cooling the fried cured beef to room temperature, packaging with a vacuum packaging bag, and carrying out ultrahigh pressure treatment (300MPa, 5 minutes) to replace irradiation, prolong the shelf life and retain the flavor, so that the method has the advantages of traditional flavor, prolonged shelf life, simple production process and the like.

The invention discloses a liquid chromatography method for measuring 5-hydroxymethylfurfural in a calcium gluconate and sodium chloride injection. The method comprises the following steps: measuring the calcium gluconate and sodium chloride injection as a test solution; weighing 5-hydroxymethylfurfural, and adding water to dilute the 5-hydroxymethylfurfural to form a reference solution; carrying out continuous sample introduction on the liquid chromatograph by using the reference substance solution to obtain a system applicability solution chromatogram; when the chromatogram of the applicable solution of the system meets the standard, measuring the test solution and the reference solution, respectively injecting the test solution and the reference solution into a liquid chromatograph, and recording the chromatograms; the content of 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection is obtained through a 5-hydroxymethylfurfural content calculation formula. The method has the advantages of strong specificity, high sensitivity, good precision, strong durability and the like, and can quantitatively detect 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection, so that the safety of clinical medication of the calcium gluconate and sodium chloride injection is improved.

The application discloses a crystallization equipment applied to an enzyme method for preparing calcium gluconate, belonging to the technical field of crystallization equipment, which comprises a tank body, a liquid adding opening is arranged on the side wall of the tank body, a cylinder body is arranged in the tank body, a cleaning rod is arranged between the cylinder body and the inner wall of the tank body, the cleaning rod is used for cleaning the inner wall of the tank body and the outer wall of the cylinder body, a plurality of plug-in plates are slidably connected to the inner bottom wall of the cylinder body, and the plurality of plug-in plates are arranged in the solution. The plug-in plates, the inner wall of the tank body and the outer wall of the cylinder body can reduce the nucleation barrier of the solution surface, the melt solution can form crystal nuclei at the locations with unevenness, and the solution can form nuclei locally at a very small cooling degree, so that the crystallization efficiency is accelerated, and the nucleation barrier condition is created for the solute to preferentially nucleate, thereby reducing the nucleation time of the solute.

The present disclosure discloses a composition for hair growth comprising Larix europea wood extract, Camellia sinesis leaf extract, Pisum sativum sprout extract, Curcuma longa (Turmeric) callus conditioned media, Hamamelis virginiana (Witch Hazel), Rosmarinus officinalis Leaf Oil, Glycerin, Glycine, Zinc Chloride, Sodium Metabisulfite, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Tetrasodium ethylenediaminetetraacetic acid (EDTA), Saccharide Isomerate, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Propanediol, Biotinoyl Tripeptide- 1, Alpha Glucosyl Hesperidin, Caffeine, Hydrolyzed Pea Protein, Polyalkylene Glycol Mono Butyl Ether, Acrylates / C 10-30 Alkyl Acrylate Crosspolymer, Panthenol, Niacinamide, Arginine, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Phenoxyethanol, and water is added to the composition until the desired volume is achieved. A method for preparing the composition for hair growth is also provided.

The invention relates to a bagging-free quality-improving and efficiency-improving pesticide for reducing the insect fruit rate of pomes and a spraying method of the bagging-free quality-improving and efficiency-improving pesticide. The quality-improving and efficiency-improving pesticide comprises the following components: 1-100 g / L of pullulan; 0.5 g / L to 2 g / L of EDTA-2NaCa; the nutrient solution is prepared from 0.3 g / L to 5 g / L of L-calcium aspartate, 1 g / L to 3 g / L of D-calcium gluconate, 2 g / L to 4 g / L of sucrose fatty acid ester, 5 g / L to 15 g / L of tea polyphenol, 2 g / L to 6 g / L of gallic acid, 0.5 mg / L to 1.5 mg / L of brassinolide, 2 g / L to 4 g / L of fumed silica, 0.1 g / L to 0.3 g / L of xanthan gum, 1 g / L to 3 g / L of D-sorbitol, 0.1 g / L to 0.5 g / L of an anti-coagulant and water serving as a solvent. After the pesticide is sprayed, the pest prevention and control effect is equal to that of bagging, the cost is reduced by 68%, sunburn and bitter pox diseases are reduced, the chlorophyll SPAD value is increased by 22%, the photosynthetic rate is increased by 18%, and high yield is promoted.

The invention relates to the technical field of biochemical engineering, in particular to calcium gluconate with a spherocrystal structure as well as a preparation method and application of the calcium gluconate. The calcium gluconate product with the spherocrystal structure can be prepared by adding 1.1 wt%-5 wt% of calcium carbonate ethanol water suspension into 5 wt%-20 wt% of gluconic acid ethanol water solution. Due to the unique spherocrystal structure, the calcium gluconate product has the remarkable advantages that the crystal form is regular, and the core performance of high dissolution rate, high bioavailability and good stability is achieved. The successful construction of the advantageous spherocrystal structure is characterized in that the reaction temperature, the reaction raw material input proportion, the concentration, the solvent system (ethanol-water) and the rotating speed are cooperatively regulated and controlled, and the regulation and control mechanism provides reliable technical support for stable formation of the spherocrystal structure. In addition, the preparation process disclosed by the invention is simple to operate, and has the advantages of environmental protection and no generation of pollutants.

The invention relates to the technical field of substance detection, and particularly discloses an HPLC-ELCD method for simultaneously detecting calcium gluconate, zinc gluconate and lysine hydrochloride and application. According to the HPLC-ELCD method for simultaneously detecting calcium gluconate, zinc gluconate and lysine hydrochloride, a cation exchange chromatographic column is adopted for isocratic elution of a sample to be detected, and a mobile phase is a methanesulfonic acid-oxalic acid solution; the mobile phase is a methanesulfonic acid-oxalic acid solution, the concentration of methanesulfonic acid is 0.002 mol / L to 0.004 mol / L, and the concentration of oxalic acid is 0.12 g / L to 0.18 g / L. The method disclosed by the invention is high in separation efficiency, good in selectivity, high in detection sensitivity and strong in operability.

The invention provides a method for preparing calcium-based nano particles by a reversed-phase microemulsion method, an organic calcium salt nano material and application of the organic calcium salt nano material as a nano drug, and belongs to the field of biomedical nano materials. The calcium-based nanoparticles can be formed by reacting calcium dodecyl benzene sulfonate with ammonium salt of corresponding ions or a hydroxyl-containing organic matter aqueous solution; the preparation method of the calcium-based nanoparticles has certain universality, and nano-material drugs including calcium succinate, calcium hypophosphite, calcium gluconate, calcium formate, calcium citrate and the like are successfully synthesized. The synthesis method is simple, mild in reaction condition, environment-friendly, high in repeatability, capable of realizing batch preparation and low in raw material cost. When the calcium salt nano-drug such as calcium succinate enters tumor cells through endocytosis, a large number of ions are brought into the cells, and suddenly excessive ions can cause osmotic pressure and homeostasis imbalance in the cells, activate a pyroptosis pathway of the cells and induce death of immunogenic cells.

The invention discloses a composite hydrogel grouting material and a preparation method and application thereof, and belongs to the technical field of hydrogel grouting materials, the composite hydrogel grouting material is a two-component system, and the two-component system comprises a component A and a component B; the component A and the component B are mixed to form an ionic covalent bi-crosslinking system, that is, calcium lactate / calcium gluconate in the component B and sodium alginate in the component A are rapidly subjected to ionic crosslinking, initial setting within 15-38 seconds is achieved, and it is ensured that slurry is rapidly formed after being injected into a flowing water channel and cannot be washed away by water flow; meanwhile, acrylamide and N, N '-methylene bisacrylamide form covalent crosslinking under the action of an initiator-accelerant, so that the structural stability of the gel is improved. The contradiction that the existing single cross-linked hydrogel is fast in gelation and low in strength and high in strength and slow in gelation is broken, and efficient leaking stoppage can be realized in a flowing water environment with the flow velocity of 0.1-1.0 m / s.

The utility model relates to the technical field of medicine production, and discloses a calcium glucarate mixing device with a quantitative blanking function, which comprises a mixing reaction main body mechanism, the mixing reaction main body mechanism comprises a mixing reaction bin body, and the mixing reaction bin body is provided with a stirring and mixing mechanism and a quantitative blanking mechanism in a matching way. According to the quantitative blanking device, the combined quantitative blanking structure design is adopted, the quantitative blanking device comprises the metering pump and the proportional valve for quantitative blanking, the observation hopper is arranged between the proportional valve and the metering pump, and the metering pump can accurately extract and convey a certain amount of materials to the observation hopper according to set parameters, so that the quantitative blanking is realized. Quantitative materials conveyed by the metering pump can be observed through the observation hopper, the quantitative valve can control the flow and the discharging amount of the materials according to the preset opening degree and time, combined quantitative discharging work is carried out through the two-stage quantitative discharging structure, and the matching degree of the discharging amount of the materials and a set value after long-time use is guaranteed.

The application provides a kind of calcium gluconate co-catalytic production equipment and method, it is related to gluconate production equipment technical field.The device reaction chamber, reaction rotating cylinder, air pump, circulating flow guide pipe, injection pipe, driving device and circulating pump;Reaction rotating cylinder is set in reaction chamber, and reaction rotating cylinder is rotatably connected with driving device;Reaction rotating cylinder is rotatably connected with the top of reaction chamber;The top of reaction chamber is provided with suction port;Air pump is communicated with suction port;Circulating flow guide pipe's flow guide inlet is communicated with reaction chamber;The flow inlet of circulating flow guide pipe is connected with circulating pump;Injection pipe's injection inlet is connected with the flow outlet of circulating pump;Injection pipe's injection outlet corresponds with liquid inlet;Gas inlet is formed in the side wall of reaction chamber.The device can efficiently improve the contact effect of oxygen and solution, and effectively utilize the oxygen generated by reaction to achieve the effect of improving oxygen utilization rate.

The invention discloses a method for detecting oxalate in calcium gluconate and sodium chloride injection, and relates to the technical field of drug analysis and detection. The detection method comprises the following steps: S1, preparing a test solution and a reference solution; s2, adding hydrochloric acid and high-purity zinc into the test solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the test solution, heating until boiling, immediately cooling, and adding hydrochloric acid and a potassium ferricyanide solution to obtain a first mixed solution; adding hydrochloric acid and high-purity zinc into the reference substance solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the reference substance solution, heating until boiling, immediately cooling, and adding a hydrochloric acid solution serving as a potassium ferricyanide solution to obtain a second mixed solution; and judging whether the content of oxalate in the test solution exceeds the standard or not by comparing the color depth of the first mixed solution and the color depth of the second mixed solution. Oxalates in the calcium gluconate and sodium chloride injection can be visually and rapidly detected through colorimetry, specificity and durability are good, and operation is easy and convenient.

To provide a composition for oral cavity containing an enzyme, excellent in stability of the enzyme, and capable of improving harsh taste.SOLUTION: The composition for the oral cavity comprises (A) sodium fluoride, (B) one or more kinds selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate and calcium pantothenate, (C) one or more kinds selected from the group consisting of condensed phosphoric acids and their alkali metal salts and (D) an enzyme.SELECTED DRAWING: None

The utility model relates to the technical field of calcium glucarate production, and discloses a precipitation device convenient for internal cleaning and used for calcium glucarate production, which comprises a tank body, a driving motor, a cross rod, a rubber scraper blade and a vibration motor, a top plate is fixed to the top in the tank body through bolts, a driving motor is installed on the top of the top plate through an installation frame, an output shaft, located in the tank body, of the driving motor is connected with a vertical rod through a connecting sleeve, connecting plates are welded to the two sides of the vertical rod at equal intervals, and side plates are fixed to one ends of the connecting plates through bolts. Rubber scrapers are fixed to the sides, away from the connecting plates, of the side plates through bolts. According to the device, D-gluconate after reaction in the tank body is vibrated through the vibration motor and the spring, the precipitation speed of the D-gluconate is increased, the rubber scraper on one side of the side plate is driven by the driving motor to clean and scrape the inner side of the tank body, the purpose of cleaning the interior of the tank body is achieved, and the device is suitable for being widely popularized and used.

The invention discloses a method for detecting glucuronic acid in a calcium gluconate bulk drug. The method has high system applicability, has incomparable advantages in specificity, quantitation limit, detection limit, linear range, repeatability and durability, and has high precision.

This invention discloses a method for preparing D-allose, relating to the field of biotransformation technology. Using D-allulose as a substrate, whole cells containing recombinant ribose-5-phosphate isomerase are added to a phosphate buffer system for biotransformation, yielding a transformation solution containing D-allose. The transformation solution is then filtered, and the supernatant is collected. Glucose isomerase and glucose oxidase are added to the supernatant, along with calcium carbonate, to convert unconverted D-allulose into calcium gluconate. The resulting mixture is then purified to obtain D-allose and calcium gluconate, respectively. This process is simple, achieves simultaneous high-value separation of the main product and byproduct, and improves the economic benefits of the product.

This invention discloses the application of gluconate compounds in the preparation of drugs for the prevention and treatment of ovarian cancer. The gluconate compounds include at least one of sodium gluconate, potassium gluconate, calcium gluconate, and zinc gluconate. The invention also discloses the application of gluconate compounds in the preparation of inhibitors of the interaction between TMEM87A protein and CHP1 protein. This invention is the first to discover and demonstrate that gluconate compounds possess significant anti-ovarian cancer activity, effectively inhibiting the proliferation and metastasis of ovarian cancer cells. It also reveals for the first time a novel anti-cancer mechanism by which sodium gluconate directly binds to TMEM87A protein and disrupts the functional complex formed between TMEM87A and CHP1 protein. This invention overcomes the technical prejudice commonly held by those skilled in the art that gluconates are merely nutritional supplements or chelating agents, providing a novel, safe, and widely available class of candidate drugs for the treatment of ovarian cancer.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

The invention discloses a lithium iron phosphate positive electrode material and a preparation method thereof, and relates to the technical field of lithium ion battery positive electrode materials, and the lithium iron phosphate positive electrode material is prepared by the following steps: preparing a lithium iron phosphate precursor from lithium carbonate and iron phosphate, then mixing a chitosan mixed solution with boric acid, calcium gluconate and a glycerol solution to prepare mixed slurry, and finally preparing the lithium iron phosphate positive electrode material. And mixing the mixed slurry with a lithium iron phosphate precursor under stirring, and finally sintering to obtain the lithium iron phosphate composite material. According to the invention, the chitosan mixed solution, boric acid and calcium gluconate are combined to realize boron and calcium co-doping in lithium iron phosphate, and meanwhile, the surface of the lithium iron phosphate precursor is coated with a carbon layer, so that the lithium iron phosphate positive electrode material with excellent electrochemical performance and tap density is obtained, the preparation cost is low, and the endurance mileage of a lithium ion battery is prolonged.

This invention relates to a method for preparing calcium gluconate using microchannel continuous flow reaction technology. Employing a Corning microchannel reactor for continuous production of calcium gluconate represents a breakthrough from conventional batch oxidation reaction processes. Under sodium nitrite / nitric acid reaction conditions, this invention utilizes a microchannel continuous flow reactor for oxidation followed by a salt conversion reaction to obtain calcium gluconate, achieving a total yield of over 90%. Compared to traditional processes, this technology offers faster reaction rates and shorter production times for calcium gluconate, solving the problem of uncontrolled exothermic reactions during scale-up in traditional batch batch reactors. It is simple to operate, significantly improves yield, allows for seamless scale-up, and minimizes environmental pollution, making it suitable for industrial production.

A method for co-producing chitin and calcium gluconate from crab or shrimp shells belongs to the field of chitin extraction and resource comprehensive utilization technology. The method includes steps such as raw material pretreatment, enzymatic deproteinization, gluconate decalcification, ultrafiltration, nanofiltration, electrodialysis separation, purification, and concentration recovery. This invention is the first to apply gluconate as a decalcifying agent to chitin extraction, achieving efficient decalcification under near-neutral, low-temperature conditions, greatly protecting the chitin molecular chain. Combining enzymatic deproteinization and ultrafiltration-nanofiltration membrane separation technology not only achieves efficient separation of chitin and calcium gluconate but also recovers the nanofiltration permeate, realizing the recycling of gluconate raw materials and water in the process. The purity of both chitin and calcium gluconate can be further improved to over 99% through an electrodialysis purification step. This invention is a green and environmentally friendly process with high resource utilization and high product added value, providing a new clean and efficient production path for the chitin industry.

To provide a composition for oral cavity having biofilm removing effect and good flavor.SOLUTION: An oral composition comprising (A) sodium fluoride, (B) one or more selected from the group consisting of calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate, (C) one or more selected from the group consisting of condensed phosphoric acids and alkali metal salts thereof, and (D) one or more selected from the group consisting of organic acids and salts thereof (excluding the component (B)).SELECTED DRAWING: None

The present application relates to the technical field of geothermal resource development and utilization, in particular to a Guantao group geothermal recharge well gel pretreatment agent, by weight percentage, comprising: citric acid: 10%-30%; organic acid: 2%-5%; corrosion inhibitor: 1%-4%; chelating agent: 0.1%-2%; iron ion stabilizer: 1%-4%; clay stabilizer: 1%-2%; anti-swelling agent: 1%-4%; calcium gluconate: 0.2%-0.4%; ferrous gluconate: 0.2%-0.4% and the rest is water. The present application does not use strong acid, strong base and strong oxidizing agent, ensuring construction safety. The system selects raw materials with the same composition as the formation water, can achieve no residue, remove the blockage of chemical agents in the oil and gas production process, reduce the seepage pressure, increase the water yield of geothermal well and recharge. Not only can prevent clay swelling, but also can realize the shrinkage of expanded clay, thereby reducing the migration of fine particles and having a certain sand prevention effect.

The invention discloses an organ maintenance liquid for repairing liver functions as well as a preparation method and application of the organ maintenance liquid. The feed additive comprises the following components: an oxygen-carrying component, succinyl gelatin, sodium chloride, sodium hydroxide, sodium bicarbonate, calcium gluconate, magnesium sulfate, chromium chloride, copper chloride, ferric chloride, manganese chloride, sodium molybdate, sodium selenite, zinc chloride, potassium iodide, sodium fluoride, isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, tryptophan, serine, valine and histidine. The injection is prepared from arginine, alanine, asparaginic acid, cysteine, glutamic acid, proline, tyrosine, glycine, sodium hydrogen sulfite, heparin, methylprednisolone sodium succinate, broad-spectrum antibiotics, antifungal drugs, FXR agonists and sterilized water for injection. The oxygen-carrying component is washed red blood cells or concentrated red blood cells or artificial blood. The viscosity of the organ maintenance liquid is closer to that of plasma, the influence on the blood coagulation function and the renal function is avoided, and the organ maintenance liquid has higher safety, can treat ischemia reperfusion injury, repair the liver biliary tract function and remarkably reduce various inflammation indexes, and is used for ischemia-free liver transplantation.

1. Name of the designed product: packing box (calcium acetate). 2. Use of the designed product: packing box. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: perspective view.

The invention discloses a high-water-solubility L-ascorbic acid-2-phosphate calcium sodium salt as well as a preparation method and application of the high-water-solubility L-ascorbic acid-2-phosphate calcium sodium salt. The 1% aqueous solution of the calcium sodium salt is free of precipitation after standing at 25 DEG C for 24 hours, and the 600 nm light transmittance of the 0.1% aqueous solution is greater than or equal to 95%. The preparation method comprises the following steps: reacting L-ascorbic acid with sodium trimetaphosphate to generate AMP sodium salt, slowly dropwise adding calcium lactate or calcium gluconate at low temperature, adding 0.1-0.5 wt% of sodium citrate as an anti-precipitation protective agent, and carrying out low-temperature spray drying (inlet air is 150-170 DEG C and outlet air is 65-75 DEG C) and cold nitrogen cooling to obtain the product. The product is specially applied to water sprinkling for aquaculture, can be completely dissolved within 30 seconds under the concentration of 10g / L, is clear and transparent in solution, effectively solves the problems of slow dissolution, turbidity and precipitation of the traditional AMP calcium sodium salt during water sprinkling, and remarkably improves the biological utilization efficiency.

The utility model relates to the technical field of grinding, and discloses grinding equipment with a mixing function for producing calcium glucarate, which comprises a mixing tank and a ball mill, two feed chutes are arranged at the upper part of the left side wall of the mixing tank, and a driving motor is arranged in the middle of the upper end of each feed chute; a driving motor is started, a stirring rod is driven by a motor shaft for mixing and stirring, stirred calcium glucarate particles enter a feeding mechanism through a leakage net and then enter a ball mill through a pipeline, the ball mill is started, the calcium glucarate particles are continuously impacted by grinding balls to be crushed, a suction fan is started, and the calcium glucarate particles are crushed. Air enters the air inlet box and then enters the ball mill, powder enters the dust remover along with airflow, the powder falls into the collecting tank through a pipeline to be collected and ground, meanwhile, uniform mixing is achieved, the quality of final products is ensured, the requirement for efficient mixing is met, the operation time is saved, and the production efficiency is improved.

The invention discloses a method for detecting related substances of calcium gluconate. The detection method is a high performance liquid chromatography-electric fog type detection method. Chromatographic conditions are as follows: a chromatographic column takes cation exchange resin as a filler, the evaporation temperature is 50-60 DEG C, the collection frequency is 8-12 Hz, the filtration constant is 4.5-5.5 s, the power function value is 1.8-2.2, the column temperature is 45-55 DEG C, the mobile phase is 0.09-0.11% trifluoroacetic acid solution, and isocratic elution is performed. The method is used; d-glucuronic acid, isomaltohexanoic acid, maltose acid, fructose, D-glucuronic acid lactone, glucose, D-gluconic acid-gamma-lactone, glucaric dialdehyde, D-gluconic acid-delta-lactone, oxalic acid, maltotriose, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2- According to the method, impurities such as 3, 5-hydroxymethyl-2-furaldehyde and the like are well separated from calcium gluconate, and the impurities in the method are relatively good in sensitivity, relatively small in baseline interference, relatively good in specificity and the like, so that the defects in the prior art can be effectively overcome, and related substances in the calcium gluconate can be effectively controlled; the safety, the effectiveness and the quality controllability of various calcium supplements prepared by taking the calcium gluconate as the raw material medicine are ensured.

The application discloses a compound calcium gluconate oral solution and a preparation process thereof. The compound calcium gluconate oral solution comprises the following raw materials in mass fractions: 40-60 parts of calcium gluconate, 40-60 parts of calcium lactate, 5-5.5 parts of a stabilizer, 140-160 parts of sucrose, 30-40 parts of glucose, 0.1-0.3 parts of essence and the balance of purified water. The pH value of the obtained compound calcium gluconate oral solution is 4.0-5.0, and the stabilizer comprises lactic acid and modified inulin in a mass ratio of 1: (0-0.08). The calcium lactate has a high solubility in water and can also serve as a solubilizer of the calcium gluconate, thereby improving the solubility of the calcium gluconate in water. The lactic acid in the stabilizer can dissociate into lactate ions, further improving the solubility of calcium ions in the system. The modified inulin has a good effect of preventing crystallization, thereby reducing the occurrence of crystallization precipitation.