51 results about "Glucobiogen" patented technology

The invention relates to the technical field of preparation of cured beef, and discloses low-salt cured beef which comprises main materials and auxiliary materials in parts by mass as preparation raw materials, the main materials comprise fresh yellow cattle meat and compound salt, and the auxiliary materials comprise tea polyphenol, alanine, calcium gluconate and a kelp powder aqueous extract. The formula comprises 100 parts of fresh yellow cattle meat, 5 parts of compound salt, 0.1 part of tea polyphenol, 0.2 part of alanine, 0.5 part of calcium gluconate and 1 part of kelp powder aqueous extract. The method comprises the following steps: putting cleaned beef strips into a microwave oven, mixing 5% of compound salt with tea polyphenol, anthocyanin, rosemary extract, alanine and calcium gluconate in order to improve the pickling efficiency, adding 50 parts of clear water, and uniformly stirring to prepare a pickling solution; and cooling the fried cured beef to room temperature, packaging with a vacuum packaging bag, and carrying out ultrahigh pressure treatment (300MPa, 5 minutes) to replace irradiation, prolong the shelf life and retain the flavor, so that the method has the advantages of traditional flavor, prolonged shelf life, simple production process and the like.

The invention discloses a liquid chromatography method for measuring 5-hydroxymethylfurfural in a calcium gluconate and sodium chloride injection. The method comprises the following steps: measuring the calcium gluconate and sodium chloride injection as a test solution; weighing 5-hydroxymethylfurfural, and adding water to dilute the 5-hydroxymethylfurfural to form a reference solution; carrying out continuous sample introduction on the liquid chromatograph by using the reference substance solution to obtain a system applicability solution chromatogram; when the chromatogram of the applicable solution of the system meets the standard, measuring the test solution and the reference solution, respectively injecting the test solution and the reference solution into a liquid chromatograph, and recording the chromatograms; the content of 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection is obtained through a 5-hydroxymethylfurfural content calculation formula. The method has the advantages of strong specificity, high sensitivity, good precision, strong durability and the like, and can quantitatively detect 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection, so that the safety of clinical medication of the calcium gluconate and sodium chloride injection is improved.

The application discloses a crystallization equipment applied to an enzyme method for preparing calcium gluconate, belonging to the technical field of crystallization equipment, which comprises a tank body, a liquid adding opening is arranged on the side wall of the tank body, a cylinder body is arranged in the tank body, a cleaning rod is arranged between the cylinder body and the inner wall of the tank body, the cleaning rod is used for cleaning the inner wall of the tank body and the outer wall of the cylinder body, a plurality of plug-in plates are slidably connected to the inner bottom wall of the cylinder body, and the plurality of plug-in plates are arranged in the solution. The plug-in plates, the inner wall of the tank body and the outer wall of the cylinder body can reduce the nucleation barrier of the solution surface, the melt solution can form crystal nuclei at the locations with unevenness, and the solution can form nuclei locally at a very small cooling degree, so that the crystallization efficiency is accelerated, and the nucleation barrier condition is created for the solute to preferentially nucleate, thereby reducing the nucleation time of the solute.

The present disclosure discloses a composition for hair growth comprising Larix europea wood extract, Camellia sinesis leaf extract, Pisum sativum sprout extract, Curcuma longa (Turmeric) callus conditioned media, Hamamelis virginiana (Witch Hazel), Rosmarinus officinalis Leaf Oil, Glycerin, Glycine, Zinc Chloride, Sodium Metabisulfite, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Tetrasodium ethylenediaminetetraacetic acid (EDTA), Saccharide Isomerate, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Propanediol, Biotinoyl Tripeptide- 1, Alpha Glucosyl Hesperidin, Caffeine, Hydrolyzed Pea Protein, Polyalkylene Glycol Mono Butyl Ether, Acrylates / C 10-30 Alkyl Acrylate Crosspolymer, Panthenol, Niacinamide, Arginine, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Phenoxyethanol, and water is added to the composition until the desired volume is achieved. A method for preparing the composition for hair growth is also provided.

The present application relates to the field of food processing technology, and more particularly to a modified frozen dough with oxidized konjac polysaccharide and a preparation method thereof. The frozen dough comprises the following raw materials in parts by weight: 850-950 parts of flour, 500-600 parts of water, 2.55-9.5 parts of oxidized konjac polysaccharide, 8.5-14.25 parts of calcium gluconate, 0.25-1 part of zinc gluconate, and 8-60 parts of a leavening agent. The leavening agent is yeast or baking powder. In the preparation, the oxidized konjac polysaccharide, calcium gluconate and zinc gluconate are uniformly dispersed in water, and then subjected to high-pressure homogenization and plasma treatment. All the raw materials are put into a dough mixer, mixed at low speed for 1-3 min, and then mixed at high speed for 3-5 min. After mixing, the dough is divided into small doughs, and rolled into small balls. The doughs are wrapped with plastic wrap and quickly frozen. The frozen dough has improved stability, and the deterioration of the specific volume of the food made from the frozen dough is improved.

The invention relates to a bagging-free quality-improving and efficiency-improving pesticide for reducing the insect fruit rate of pomes and a spraying method of the bagging-free quality-improving and efficiency-improving pesticide. The quality-improving and efficiency-improving pesticide comprises the following components: 1-100 g / L of pullulan; 0.5 g / L to 2 g / L of EDTA-2NaCa; the nutrient solution is prepared from 0.3 g / L to 5 g / L of L-calcium aspartate, 1 g / L to 3 g / L of D-calcium gluconate, 2 g / L to 4 g / L of sucrose fatty acid ester, 5 g / L to 15 g / L of tea polyphenol, 2 g / L to 6 g / L of gallic acid, 0.5 mg / L to 1.5 mg / L of brassinolide, 2 g / L to 4 g / L of fumed silica, 0.1 g / L to 0.3 g / L of xanthan gum, 1 g / L to 3 g / L of D-sorbitol, 0.1 g / L to 0.5 g / L of an anti-coagulant and water serving as a solvent. After the pesticide is sprayed, the pest prevention and control effect is equal to that of bagging, the cost is reduced by 68%, sunburn and bitter pox diseases are reduced, the chlorophyll SPAD value is increased by 22%, the photosynthetic rate is increased by 18%, and high yield is promoted.

The invention relates to the technical field of biochemical engineering, in particular to calcium gluconate with a spherocrystal structure as well as a preparation method and application of the calcium gluconate. The calcium gluconate product with the spherocrystal structure can be prepared by adding 1.1 wt%-5 wt% of calcium carbonate ethanol water suspension into 5 wt%-20 wt% of gluconic acid ethanol water solution. Due to the unique spherocrystal structure, the calcium gluconate product has the remarkable advantages that the crystal form is regular, and the core performance of high dissolution rate, high bioavailability and good stability is achieved. The successful construction of the advantageous spherocrystal structure is characterized in that the reaction temperature, the reaction raw material input proportion, the concentration, the solvent system (ethanol-water) and the rotating speed are cooperatively regulated and controlled, and the regulation and control mechanism provides reliable technical support for stable formation of the spherocrystal structure. In addition, the preparation process disclosed by the invention is simple to operate, and has the advantages of environmental protection and no generation of pollutants.

The invention relates to the technical field of substance detection, and particularly discloses an HPLC-ELCD method for simultaneously detecting calcium gluconate, zinc gluconate and lysine hydrochloride and application. According to the HPLC-ELCD method for simultaneously detecting calcium gluconate, zinc gluconate and lysine hydrochloride, a cation exchange chromatographic column is adopted for isocratic elution of a sample to be detected, and a mobile phase is a methanesulfonic acid-oxalic acid solution; the mobile phase is a methanesulfonic acid-oxalic acid solution, the concentration of methanesulfonic acid is 0.002 mol / L to 0.004 mol / L, and the concentration of oxalic acid is 0.12 g / L to 0.18 g / L. The method disclosed by the invention is high in separation efficiency, good in selectivity, high in detection sensitivity and strong in operability.

The invention provides a method for preparing calcium-based nano particles by a reversed-phase microemulsion method, an organic calcium salt nano material and application of the organic calcium salt nano material as a nano drug, and belongs to the field of biomedical nano materials. The calcium-based nanoparticles can be formed by reacting calcium dodecyl benzene sulfonate with ammonium salt of corresponding ions or a hydroxyl-containing organic matter aqueous solution; the preparation method of the calcium-based nanoparticles has certain universality, and nano-material drugs including calcium succinate, calcium hypophosphite, calcium gluconate, calcium formate, calcium citrate and the like are successfully synthesized. The synthesis method is simple, mild in reaction condition, environment-friendly, high in repeatability, capable of realizing batch preparation and low in raw material cost. When the calcium salt nano-drug such as calcium succinate enters tumor cells through endocytosis, a large number of ions are brought into the cells, and suddenly excessive ions can cause osmotic pressure and homeostasis imbalance in the cells, activate a pyroptosis pathway of the cells and induce death of immunogenic cells.

The invention discloses a composite hydrogel grouting material and a preparation method and application thereof, and belongs to the technical field of hydrogel grouting materials, the composite hydrogel grouting material is a two-component system, and the two-component system comprises a component A and a component B; the component A and the component B are mixed to form an ionic covalent bi-crosslinking system, that is, calcium lactate / calcium gluconate in the component B and sodium alginate in the component A are rapidly subjected to ionic crosslinking, initial setting within 15-38 seconds is achieved, and it is ensured that slurry is rapidly formed after being injected into a flowing water channel and cannot be washed away by water flow; meanwhile, acrylamide and N, N '-methylene bisacrylamide form covalent crosslinking under the action of an initiator-accelerant, so that the structural stability of the gel is improved. The contradiction that the existing single cross-linked hydrogel is fast in gelation and low in strength and high in strength and slow in gelation is broken, and efficient leaking stoppage can be realized in a flowing water environment with the flow velocity of 0.1-1.0 m / s.

The application provides a kind of calcium gluconate co-catalytic production equipment and method, it is related to gluconate production equipment technical field.The device reaction chamber, reaction rotating cylinder, air pump, circulating flow guide pipe, injection pipe, driving device and circulating pump;Reaction rotating cylinder is set in reaction chamber, and reaction rotating cylinder is rotatably connected with driving device;Reaction rotating cylinder is rotatably connected with the top of reaction chamber;The top of reaction chamber is provided with suction port;Air pump is communicated with suction port;Circulating flow guide pipe's flow guide inlet is communicated with reaction chamber;The flow inlet of circulating flow guide pipe is connected with circulating pump;Injection pipe's injection inlet is connected with the flow outlet of circulating pump;Injection pipe's injection outlet corresponds with liquid inlet;Gas inlet is formed in the side wall of reaction chamber.The device can efficiently improve the contact effect of oxygen and solution, and effectively utilize the oxygen generated by reaction to achieve the effect of improving oxygen utilization rate.

The invention discloses a method for detecting oxalate in calcium gluconate and sodium chloride injection, and relates to the technical field of drug analysis and detection. The detection method comprises the following steps: S1, preparing a test solution and a reference solution; s2, adding hydrochloric acid and high-purity zinc into the test solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the test solution, heating until boiling, immediately cooling, and adding hydrochloric acid and a potassium ferricyanide solution to obtain a first mixed solution; adding hydrochloric acid and high-purity zinc into the reference substance solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the reference substance solution, heating until boiling, immediately cooling, and adding a hydrochloric acid solution serving as a potassium ferricyanide solution to obtain a second mixed solution; and judging whether the content of oxalate in the test solution exceeds the standard or not by comparing the color depth of the first mixed solution and the color depth of the second mixed solution. Oxalates in the calcium gluconate and sodium chloride injection can be visually and rapidly detected through colorimetry, specificity and durability are good, and operation is easy and convenient.

To provide a composition for oral cavity containing an enzyme, excellent in stability of the enzyme, and capable of improving harsh taste.SOLUTION: The composition for the oral cavity comprises (A) sodium fluoride, (B) one or more kinds selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate and calcium pantothenate, (C) one or more kinds selected from the group consisting of condensed phosphoric acids and their alkali metal salts and (D) an enzyme.SELECTED DRAWING: None

The invention discloses a method for detecting glucuronic acid in a calcium gluconate bulk drug. The method has high system applicability, has incomparable advantages in specificity, quantitation limit, detection limit, linear range, repeatability and durability, and has high precision.

Provided is an oral composition having good fluorine ion retention properties and good low-temperature storage stability. An oral composition containing: (A) sodium fluoride; (B) one or more substances selected from the group consisting of calcium lactate, calcium gluconate, calcium chloride, and calcium pantothenate; (C) one or more substances selected from condensed phosphoric acid and alkali metal salts thereof; and (D) isopropyl methyl phenol.

This invention discloses a method for preparing D-allose, relating to the field of biotransformation technology. Using D-allulose as a substrate, whole cells containing recombinant ribose-5-phosphate isomerase are added to a phosphate buffer system for biotransformation, yielding a transformation solution containing D-allose. The transformation solution is then filtered, and the supernatant is collected. Glucose isomerase and glucose oxidase are added to the supernatant, along with calcium carbonate, to convert unconverted D-allulose into calcium gluconate. The resulting mixture is then purified to obtain D-allose and calcium gluconate, respectively. This process is simple, achieves simultaneous high-value separation of the main product and byproduct, and improves the economic benefits of the product.

This invention discloses the application of gluconate compounds in the preparation of drugs for the prevention and treatment of ovarian cancer. The gluconate compounds include at least one of sodium gluconate, potassium gluconate, calcium gluconate, and zinc gluconate. The invention also discloses the application of gluconate compounds in the preparation of inhibitors of the interaction between TMEM87A protein and CHP1 protein. This invention is the first to discover and demonstrate that gluconate compounds possess significant anti-ovarian cancer activity, effectively inhibiting the proliferation and metastasis of ovarian cancer cells. It also reveals for the first time a novel anti-cancer mechanism by which sodium gluconate directly binds to TMEM87A protein and disrupts the functional complex formed between TMEM87A and CHP1 protein. This invention overcomes the technical prejudice commonly held by those skilled in the art that gluconates are merely nutritional supplements or chelating agents, providing a novel, safe, and widely available class of candidate drugs for the treatment of ovarian cancer.

The utility model discloses a calcium zinc gluconate solution storage device, which belongs to the technical field of medicine storage and comprises a storage box, a plurality of accommodating grooves are arranged on the storage box, four clamping plates are arranged in the accommodating grooves, and one side of each clamping plate is fixedly connected with two telescopic rods. According to the calcium and zinc gluconate solution storage device, clamping plates, springs, a containing groove and a medicament bottle are arranged, when the medicament bottle needs to be stored, the medicament bottle is firstly placed among the four clamping plates and pressed downwards, due to the fact that the clamping plates are designed to be arc faces, when the medicament bottle is pressed downwards, the medicament bottle can push the clamping plates by a certain distance, and the clamping plates compress the springs; when the medicine bottles are pressed down to the bottoms of the containing grooves, the springs can apply reverse thrust to the clamping plates at the moment, so that the medicine bottles are clamped through the four clamping plates, due to the mobility of the clamping plates, the device can store the medicine bottles of different specifications, and the use range of the device is widened.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

To provide a composition for oral cavity having biofilm removing effect and good flavor.SOLUTION: An oral composition comprising (A) sodium fluoride, (B) one or more selected from the group consisting of calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate, (C) one or more selected from the group consisting of condensed phosphoric acids and alkali metal salts thereof, and (D) one or more selected from the group consisting of organic acids and salts thereof (excluding the component (B)).SELECTED DRAWING: None

The invention discloses an organ maintenance liquid for repairing liver functions as well as a preparation method and application of the organ maintenance liquid. The feed additive comprises the following components: an oxygen-carrying component, succinyl gelatin, sodium chloride, sodium hydroxide, sodium bicarbonate, calcium gluconate, magnesium sulfate, chromium chloride, copper chloride, ferric chloride, manganese chloride, sodium molybdate, sodium selenite, zinc chloride, potassium iodide, sodium fluoride, isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, tryptophan, serine, valine and histidine. The injection is prepared from arginine, alanine, asparaginic acid, cysteine, glutamic acid, proline, tyrosine, glycine, sodium hydrogen sulfite, heparin, methylprednisolone sodium succinate, broad-spectrum antibiotics, antifungal drugs, FXR agonists and sterilized water for injection. The oxygen-carrying component is washed red blood cells or concentrated red blood cells or artificial blood. The viscosity of the organ maintenance liquid is closer to that of plasma, the influence on the blood coagulation function and the renal function is avoided, and the organ maintenance liquid has higher safety, can treat ischemia reperfusion injury, repair the liver biliary tract function and remarkably reduce various inflammation indexes, and is used for ischemia-free liver transplantation.

The invention relates to a method for detecting gluconic acid related substances in a compound calcium gluconate oral solution, which belongs to the field of detection, and adopts correction factor determination to realize accurate quantification of D-glucose-gamma-lactone and D-glucose-delta-lactone. Through the determination of the correction factor, a reference substance solution is not needed in the subsequent detection process, so that the problem that the detection accuracy is still difficult to meet when the reference substance solution is prepared at present is solved, and the detection efficiency of a large number of samples in actual production is remarkably improved. The method can be used as a method for detecting D-glucose-gamma-lactone and D-glucose-delta-lactone in gluconic acid-containing samples such as a compound calcium gluconate oral solution, has the characteristics of high specificity, high sensitivity, high accuracy, good durability and the like, has the advantages of universality, practicability and the like, and is simpler, more convenient and more efficient to operate.

The invention discloses a high-water-solubility L-ascorbic acid-2-phosphate calcium sodium salt as well as a preparation method and application of the high-water-solubility L-ascorbic acid-2-phosphate calcium sodium salt. The 1% aqueous solution of the calcium sodium salt is free of precipitation after standing at 25 DEG C for 24 hours, and the 600 nm light transmittance of the 0.1% aqueous solution is greater than or equal to 95%. The preparation method comprises the following steps: reacting L-ascorbic acid with sodium trimetaphosphate to generate AMP sodium salt, slowly dropwise adding calcium lactate or calcium gluconate at low temperature, adding 0.1-0.5 wt% of sodium citrate as an anti-precipitation protective agent, and carrying out low-temperature spray drying (inlet air is 150-170 DEG C and outlet air is 65-75 DEG C) and cold nitrogen cooling to obtain the product. The product is specially applied to water sprinkling for aquaculture, can be completely dissolved within 30 seconds under the concentration of 10g / L, is clear and transparent in solution, effectively solves the problems of slow dissolution, turbidity and precipitation of the traditional AMP calcium sodium salt during water sprinkling, and remarkably improves the biological utilization efficiency.

The invention discloses a method for detecting related substances of calcium gluconate. The detection method is a high performance liquid chromatography-electric fog type detection method. Chromatographic conditions are as follows: a chromatographic column takes cation exchange resin as a filler, the evaporation temperature is 50-60 DEG C, the collection frequency is 8-12 Hz, the filtration constant is 4.5-5.5 s, the power function value is 1.8-2.2, the column temperature is 45-55 DEG C, the mobile phase is 0.09-0.11% trifluoroacetic acid solution, and isocratic elution is performed. The method is used; d-glucuronic acid, isomaltohexanoic acid, maltose acid, fructose, D-glucuronic acid lactone, glucose, D-gluconic acid-gamma-lactone, glucaric dialdehyde, D-gluconic acid-delta-lactone, oxalic acid, maltotriose, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-hydroxymethyl-2- According to the method, impurities such as 3, 5-hydroxymethyl-2-furaldehyde and the like are well separated from calcium gluconate, and the impurities in the method are relatively good in sensitivity, relatively small in baseline interference, relatively good in specificity and the like, so that the defects in the prior art can be effectively overcome, and related substances in the calcium gluconate can be effectively controlled; the safety, the effectiveness and the quality controllability of various calcium supplements prepared by taking the calcium gluconate as the raw material medicine are ensured.

The application discloses a compound calcium gluconate oral solution and a preparation process thereof. The compound calcium gluconate oral solution comprises the following raw materials in mass fractions: 40-60 parts of calcium gluconate, 40-60 parts of calcium lactate, 5-5.5 parts of a stabilizer, 140-160 parts of sucrose, 30-40 parts of glucose, 0.1-0.3 parts of essence and the balance of purified water. The pH value of the obtained compound calcium gluconate oral solution is 4.0-5.0, and the stabilizer comprises lactic acid and modified inulin in a mass ratio of 1: (0-0.08). The calcium lactate has a high solubility in water and can also serve as a solubilizer of the calcium gluconate, thereby improving the solubility of the calcium gluconate in water. The lactic acid in the stabilizer can dissociate into lactate ions, further improving the solubility of calcium ions in the system. The modified inulin has a good effect of preventing crystallization, thereby reducing the occurrence of crystallization precipitation.

The utility model discloses a calcium zinc gluconate oral solution filling device which comprises a tank body, one side of the top of the tank body is fixedly connected with a supplementing hopper, the lower portions of the two sides of the outer wall of the tank body are fixedly connected with mounting plates, the bottom of the tank body is provided with a cleaning device, and the top of the tank body is fixedly connected with a controller. A distance sensor is fixedly connected to the side, close to the supplementing hopper, of the bottom of the tank body and electrically connected with the controller. The utility model relates to the technical field of glucose, the calcium zinc gluconate oral solution filling device can more conveniently adjust the injection amount through the matching of the tank body, the injection device and the cleaning device, and can automatically clean the residual glucose in the injection pipe after the operation is finished, so that the operation is more convenient, and the production efficiency is improved. Therefore, sticky glucose is prevented from being contaminated by dust after the glucose is air-dried, the subsequent medicine injection quality can be guaranteed, and the use of workers is facilitated.

The embodiment of the invention discloses a peptide calcium chelate as well as a preparation method and application thereof. The preparation method of the peptide calcium chelate comprises the following steps: mixing a calcium solution with a wolfberry glycopeptide liquid, adjusting the pH value of the system, carrying out a chelation reaction, cooling with ice water, adding ethanol, centrifuging, and freeze-drying the obtained precipitate to obtain the peptide calcium chelate. The peptide calcium chelate provided by the invention has remarkable calcium supplement advantage and biological activity, calcium extracted from bovine bones and wolfberry peptides are chelated to form a stable compound, the stability of calcium is remarkably improved, the peptide calcium chelate is more convenient to carry and take, and the solubility and absorptivity of calcium ions are increased. Meanwhile, limitation of traditional calcium ion absorption can be avoided through an intestinal peptide transfer channel (such as PepT1), and interference of antagonists in diet is reduced. Scanning electron microscope results prove that the fructus lycii peptide calcium is successfully prepared, and animal experiments show that the fructus lycii peptide calcium can effectively improve the serum calcium level, improve the bone microstructure, increase the bone mineral density and the number of bone trabecula and regulate bone metabolism indexes, and shows a calcium supplement effect and a bone protection effect superior to those of a traditional calcium agent (such as calcium gluconate); the calcium supplement is a novel calcium supplement with high bioavailability and a bone health promoting function.

The invention discloses a micron-sized liquid calcium composition for promoting calcium absorption and a preparation method of the micron-sized liquid calcium composition, and belongs to the technical field of calcium supplements. The composition comprises the following raw materials: calcium citrate, milk mineral salt, calcium gluconate, casein peptide, hydrolyzed yolk peptide, L-lysine, vitamin D microcapsule powder, natto powder, xanthan gum, L-malic acid, xylitol, fructo-oligosaccharide, concentrated fruit juice, edible essence and water. The preparation method comprises the following steps: weighing, premixing, pretreating, preparing liquid, suspending, homogenizing and emulsifying, fixing volume, filling and sealing, and sterilizing. Practice verifies that the technology is advanced, the scheme is systematic, the benefit is remarkable, the industrial pain points that a traditional calcium agent is difficult to dissolve, poor in absorption and poor in taste are thoroughly solved, the economic and social benefits are huge, and great significance is achieved for promoting the high-quality development of the nutrition and health industry in China.

The disclosure is directed to stabilized aqueous compositions containing calcium (in the form of calcium lactate and calcium gluconate), vitamin D3, and vitamin K2. In addition to calcium, vitamin D3, and vitamin K2, the compositions contain an emulsifier (such as e.g., a polysorbate), an antioxidant (such as e.g., ascorbic acid) and one or more of a sweetener (such as e.g., sucralose and sorbitol), a preservative, a flavoring agent, a pH adjuster, or a combination thereof. The disclosure also includes using the compositions to support bone health.