71 results about "Glucobiogen" patented technology

The invention provides autologous platelet-containing plasma gel and a preparation method and application thereof, and relates to the technical field of biological medicine and tissue engineering.The preparation method comprises the following steps that peripheral venous blood of a patient is extracted and added into a centrifugal tube mixed with a sodium citrate anticoagulant; putting the centrifugal tube into a centrifugal machine for centrifuging, and taking upper-layer plasma; wherein the upper-layer plasma refers to plasma between the upper-layer liquid level and the lower-layer red blood cell layer by 1mm; the centrifugal speed ranges from 1300 r / min to 1700 r / min; the centrifugation time is 3-5 min; under a sterile condition, preparing a calcium gluconate / thrombin mixed solution; and dropping the calcium gluconate / thrombin mixed solution into the upper plasma, mixing, and solidifying to obtain the autologous platelet-containing plasma gel. After one-time centrifugation, upper-layer full-layer plasma is extracted, the volume of the prepared gel is far larger than that of a traditional method, the utilization rate of whole blood platelets and fibrinogen is close to 100%, and regeneration and repair of large-area tissue wounds can be met.

The invention relates to the technical field of preparation of cured beef, and discloses low-salt cured beef which comprises main materials and auxiliary materials in parts by mass as preparation raw materials, the main materials comprise fresh yellow cattle meat and compound salt, and the auxiliary materials comprise tea polyphenol, alanine, calcium gluconate and a kelp powder aqueous extract. The formula comprises 100 parts of fresh yellow cattle meat, 5 parts of compound salt, 0.1 part of tea polyphenol, 0.2 part of alanine, 0.5 part of calcium gluconate and 1 part of kelp powder aqueous extract. The method comprises the following steps: putting cleaned beef strips into a microwave oven, mixing 5% of compound salt with tea polyphenol, anthocyanin, rosemary extract, alanine and calcium gluconate in order to improve the pickling efficiency, adding 50 parts of clear water, and uniformly stirring to prepare a pickling solution; and cooling the fried cured beef to room temperature, packaging with a vacuum packaging bag, and carrying out ultrahigh pressure treatment (300MPa, 5 minutes) to replace irradiation, prolong the shelf life and retain the flavor, so that the method has the advantages of traditional flavor, prolonged shelf life, simple production process and the like.

The invention discloses a liquid chromatography method for measuring 5-hydroxymethylfurfural in a calcium gluconate and sodium chloride injection. The method comprises the following steps: measuring the calcium gluconate and sodium chloride injection as a test solution; weighing 5-hydroxymethylfurfural, and adding water to dilute the 5-hydroxymethylfurfural to form a reference solution; carrying out continuous sample introduction on the liquid chromatograph by using the reference substance solution to obtain a system applicability solution chromatogram; when the chromatogram of the applicable solution of the system meets the standard, measuring the test solution and the reference solution, respectively injecting the test solution and the reference solution into a liquid chromatograph, and recording the chromatograms; the content of 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection is obtained through a 5-hydroxymethylfurfural content calculation formula. The method has the advantages of strong specificity, high sensitivity, good precision, strong durability and the like, and can quantitatively detect 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection, so that the safety of clinical medication of the calcium gluconate and sodium chloride injection is improved.

The application discloses a crystallization equipment applied to an enzyme method for preparing calcium gluconate, belonging to the technical field of crystallization equipment, which comprises a tank body, a liquid adding opening is arranged on the side wall of the tank body, a cylinder body is arranged in the tank body, a cleaning rod is arranged between the cylinder body and the inner wall of the tank body, the cleaning rod is used for cleaning the inner wall of the tank body and the outer wall of the cylinder body, a plurality of plug-in plates are slidably connected to the inner bottom wall of the cylinder body, and the plurality of plug-in plates are arranged in the solution. The plug-in plates, the inner wall of the tank body and the outer wall of the cylinder body can reduce the nucleation barrier of the solution surface, the melt solution can form crystal nuclei at the locations with unevenness, and the solution can form nuclei locally at a very small cooling degree, so that the crystallization efficiency is accelerated, and the nucleation barrier condition is created for the solute to preferentially nucleate, thereby reducing the nucleation time of the solute.

The present disclosure discloses a composition for hair growth comprising Larix europea wood extract, Camellia sinesis leaf extract, Pisum sativum sprout extract, Curcuma longa (Turmeric) callus conditioned media, Hamamelis virginiana (Witch Hazel), Rosmarinus officinalis Leaf Oil, Glycerin, Glycine, Zinc Chloride, Sodium Metabisulfite, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Tetrasodium ethylenediaminetetraacetic acid (EDTA), Saccharide Isomerate, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Propanediol, Biotinoyl Tripeptide- 1, Alpha Glucosyl Hesperidin, Caffeine, Hydrolyzed Pea Protein, Polyalkylene Glycol Mono Butyl Ether, Acrylates / C 10-30 Alkyl Acrylate Crosspolymer, Panthenol, Niacinamide, Arginine, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Phenoxyethanol, and water is added to the composition until the desired volume is achieved. A method for preparing the composition for hair growth is also provided.

The present application relates to the field of food processing technology, and more particularly to a modified frozen dough with oxidized konjac polysaccharide and a preparation method thereof. The frozen dough comprises the following raw materials in parts by weight: 850-950 parts of flour, 500-600 parts of water, 2.55-9.5 parts of oxidized konjac polysaccharide, 8.5-14.25 parts of calcium gluconate, 0.25-1 part of zinc gluconate, and 8-60 parts of a leavening agent. The leavening agent is yeast or baking powder. In the preparation, the oxidized konjac polysaccharide, calcium gluconate and zinc gluconate are uniformly dispersed in water, and then subjected to high-pressure homogenization and plasma treatment. All the raw materials are put into a dough mixer, mixed at low speed for 1-3 min, and then mixed at high speed for 3-5 min. After mixing, the dough is divided into small doughs, and rolled into small balls. The doughs are wrapped with plastic wrap and quickly frozen. The frozen dough has improved stability, and the deterioration of the specific volume of the food made from the frozen dough is improved.

The invention relates to a bagging-free quality-improving and efficiency-improving pesticide for reducing the insect fruit rate of pomes and a spraying method of the bagging-free quality-improving and efficiency-improving pesticide. The quality-improving and efficiency-improving pesticide comprises the following components: 1-100 g / L of pullulan; 0.5 g / L to 2 g / L of EDTA-2NaCa; the nutrient solution is prepared from 0.3 g / L to 5 g / L of L-calcium aspartate, 1 g / L to 3 g / L of D-calcium gluconate, 2 g / L to 4 g / L of sucrose fatty acid ester, 5 g / L to 15 g / L of tea polyphenol, 2 g / L to 6 g / L of gallic acid, 0.5 mg / L to 1.5 mg / L of brassinolide, 2 g / L to 4 g / L of fumed silica, 0.1 g / L to 0.3 g / L of xanthan gum, 1 g / L to 3 g / L of D-sorbitol, 0.1 g / L to 0.5 g / L of an anti-coagulant and water serving as a solvent. After the pesticide is sprayed, the pest prevention and control effect is equal to that of bagging, the cost is reduced by 68%, sunburn and bitter pox diseases are reduced, the chlorophyll SPAD value is increased by 22%, the photosynthetic rate is increased by 18%, and high yield is promoted.

The invention relates to the technical field of biochemical engineering, in particular to calcium gluconate with a spherocrystal structure as well as a preparation method and application of the calcium gluconate. The calcium gluconate product with the spherocrystal structure can be prepared by adding 1.1 wt%-5 wt% of calcium carbonate ethanol water suspension into 5 wt%-20 wt% of gluconic acid ethanol water solution. Due to the unique spherocrystal structure, the calcium gluconate product has the remarkable advantages that the crystal form is regular, and the core performance of high dissolution rate, high bioavailability and good stability is achieved. The successful construction of the advantageous spherocrystal structure is characterized in that the reaction temperature, the reaction raw material input proportion, the concentration, the solvent system (ethanol-water) and the rotating speed are cooperatively regulated and controlled, and the regulation and control mechanism provides reliable technical support for stable formation of the spherocrystal structure. In addition, the preparation process disclosed by the invention is simple to operate, and has the advantages of environmental protection and no generation of pollutants.

An oral care composition is disclosed comprising tetracalcium phosphate and a water-soluble calcium source; wherein the water-soluble calcium source comprises calcium chloride, calcium nitrate, calcium acetate, calcium lactate, calcium formate, calcium malate, calcium propionate, calcium butyrate, calcium bicarbonate, calcium glycerophosphate, calcium gluconate, calcium ascorbate, calcium glycinate or mixtures thereof; and wherein the composition is an aqueous composition and the water content is at least 5% by weight of the composition.

The utility model discloses a stock solution filtering device for preparing a calcium zinc gluconate oral solution, which comprises a stock solution storage tank and a filtering tank, the outer surface of the stock solution storage tank is fixedly communicated with an eduction pipe, the outer surface of the filtering tank is fixedly communicated with an ingress pipe, and a multi-layer processing mechanism is arranged between the eduction pipe and the ingress pipe. The multi-layer treatment mechanism is used for carrying out pre-filtration treatment on the stock solution and extracting impurities or particles in the stock solution after pre-filtration, and relates to the technical field of stock solution filtration for preparing the calcium and zinc gluconate oral solution. Furthermore, the collecting box with impurities is extracted from the interior of the treatment box, and the collecting box without impurities is put into the treatment box, so that the conveying of the stock solution does not need to be stopped when the collecting boxes are replaced, and the filtering efficiency of the stock solution is ensured.

The invention relates to the technical field of substance detection, and particularly discloses an HPLC-ELCD method for simultaneously detecting calcium gluconate, zinc gluconate and lysine hydrochloride and application. According to the HPLC-ELCD method for simultaneously detecting calcium gluconate, zinc gluconate and lysine hydrochloride, a cation exchange chromatographic column is adopted for isocratic elution of a sample to be detected, and a mobile phase is a methanesulfonic acid-oxalic acid solution; the mobile phase is a methanesulfonic acid-oxalic acid solution, the concentration of methanesulfonic acid is 0.002 mol / L to 0.004 mol / L, and the concentration of oxalic acid is 0.12 g / L to 0.18 g / L. The method disclosed by the invention is high in separation efficiency, good in selectivity, high in detection sensitivity and strong in operability.

The invention provides a method for preparing calcium-based nano particles by a reversed-phase microemulsion method, an organic calcium salt nano material and application of the organic calcium salt nano material as a nano drug, and belongs to the field of biomedical nano materials. The calcium-based nanoparticles can be formed by reacting calcium dodecyl benzene sulfonate with ammonium salt of corresponding ions or a hydroxyl-containing organic matter aqueous solution; the preparation method of the calcium-based nanoparticles has certain universality, and nano-material drugs including calcium succinate, calcium hypophosphite, calcium gluconate, calcium formate, calcium citrate and the like are successfully synthesized. The synthesis method is simple, mild in reaction condition, environment-friendly, high in repeatability, capable of realizing batch preparation and low in raw material cost. When the calcium salt nano-drug such as calcium succinate enters tumor cells through endocytosis, a large number of ions are brought into the cells, and suddenly excessive ions can cause osmotic pressure and homeostasis imbalance in the cells, activate a pyroptosis pathway of the cells and induce death of immunogenic cells.

The invention discloses a compound microorganism feed additive for promoting the growth of livestock and poultry. The compound microorganism feed additive comprises microorganism strains, natural plant components and auxiliary materials, the microbial strains comprise 8 to 12 parts of candida utilis, 5 to 9 parts of bacillus licheniformis, 2 to 4 parts of bacillus subtilis, 8 to 12 parts of aspergillus niger, 8 to 12 parts of lactobacillus delbrueckii, 8 to 12 parts of lactobacillus acidophilus, 8 to 12 parts of bifidobacterium and 3 to 7 parts of lactobacillus salivarius; the natural plant components comprise 0.5 to 2 parts of moringa seed powder; the auxiliary materials comprise 20 to 30 parts of cane sugar, 10 to 15 parts of fish meal, 2 to 3 parts of grease, 10 to 20 parts of soybean meal, 5 to 10 parts of pupa powder, 10 to 15 parts of zinc lactate, 1 to 2 parts of calcium gluconate, 3 to 5 parts of calcium carbonate and 2 to 4 parts of paeonol. Microbial strains in the compound microbial feed additive can generate various growth regulatory factors such as vitamins, amino acids and organic acids, so that the growth and development of livestock and poultry are stimulated, and the growth speed is increased.

The invention discloses a composite hydrogel grouting material and a preparation method and application thereof, and belongs to the technical field of hydrogel grouting materials, the composite hydrogel grouting material is a two-component system, and the two-component system comprises a component A and a component B; the component A and the component B are mixed to form an ionic covalent bi-crosslinking system, that is, calcium lactate / calcium gluconate in the component B and sodium alginate in the component A are rapidly subjected to ionic crosslinking, initial setting within 15-38 seconds is achieved, and it is ensured that slurry is rapidly formed after being injected into a flowing water channel and cannot be washed away by water flow; meanwhile, acrylamide and N, N '-methylene bisacrylamide form covalent crosslinking under the action of an initiator-accelerant, so that the structural stability of the gel is improved. The contradiction that the existing single cross-linked hydrogel is fast in gelation and low in strength and high in strength and slow in gelation is broken, and efficient leaking stoppage can be realized in a flowing water environment with the flow velocity of 0.1-1.0 m / s.

The application provides a kind of calcium gluconate co-catalytic production equipment and method, it is related to gluconate production equipment technical field.The device reaction chamber, reaction rotating cylinder, air pump, circulating flow guide pipe, injection pipe, driving device and circulating pump;Reaction rotating cylinder is set in reaction chamber, and reaction rotating cylinder is rotatably connected with driving device;Reaction rotating cylinder is rotatably connected with the top of reaction chamber;The top of reaction chamber is provided with suction port;Air pump is communicated with suction port;Circulating flow guide pipe's flow guide inlet is communicated with reaction chamber;The flow inlet of circulating flow guide pipe is connected with circulating pump;Injection pipe's injection inlet is connected with the flow outlet of circulating pump;Injection pipe's injection outlet corresponds with liquid inlet;Gas inlet is formed in the side wall of reaction chamber.The device can efficiently improve the contact effect of oxygen and solution, and effectively utilize the oxygen generated by reaction to achieve the effect of improving oxygen utilization rate.

The invention discloses a method for detecting oxalate in calcium gluconate and sodium chloride injection, and relates to the technical field of drug analysis and detection. The detection method comprises the following steps: S1, preparing a test solution and a reference solution; s2, adding hydrochloric acid and high-purity zinc into the test solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the test solution, heating until boiling, immediately cooling, and adding hydrochloric acid and a potassium ferricyanide solution to obtain a first mixed solution; adding hydrochloric acid and high-purity zinc into the reference substance solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the reference substance solution, heating until boiling, immediately cooling, and adding a hydrochloric acid solution serving as a potassium ferricyanide solution to obtain a second mixed solution; and judging whether the content of oxalate in the test solution exceeds the standard or not by comparing the color depth of the first mixed solution and the color depth of the second mixed solution. Oxalates in the calcium gluconate and sodium chloride injection can be visually and rapidly detected through colorimetry, specificity and durability are good, and operation is easy and convenient.

1. The name of this design product: packaging box (calcium zinc gluconate). 2. Application of this design product: used for medicine packaging boxes. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

To provide a composition for oral cavity containing an enzyme, excellent in stability of the enzyme, and capable of improving harsh taste.SOLUTION: The composition for the oral cavity comprises (A) sodium fluoride, (B) one or more kinds selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate and calcium pantothenate, (C) one or more kinds selected from the group consisting of condensed phosphoric acids and their alkali metal salts and (D) an enzyme.SELECTED DRAWING: None

The invention discloses a method for detecting glucuronic acid in a calcium gluconate bulk drug. The method has high system applicability, has incomparable advantages in specificity, quantitation limit, detection limit, linear range, repeatability and durability, and has high precision.

Provided is an oral composition having good fluorine ion retention properties and good low-temperature storage stability. An oral composition containing: (A) sodium fluoride; (B) one or more substances selected from the group consisting of calcium lactate, calcium gluconate, calcium chloride, and calcium pantothenate; (C) one or more substances selected from condensed phosphoric acid and alkali metal salts thereof; and (D) isopropyl methyl phenol.

This invention discloses a method for preparing D-allose, relating to the field of biotransformation technology. Using D-allulose as a substrate, whole cells containing recombinant ribose-5-phosphate isomerase are added to a phosphate buffer system for biotransformation, yielding a transformation solution containing D-allose. The transformation solution is then filtered, and the supernatant is collected. Glucose isomerase and glucose oxidase are added to the supernatant, along with calcium carbonate, to convert unconverted D-allulose into calcium gluconate. The resulting mixture is then purified to obtain D-allose and calcium gluconate, respectively. This process is simple, achieves simultaneous high-value separation of the main product and byproduct, and improves the economic benefits of the product.

The invention provides a trace element formula suitable for industrial recirculating aquaculture of penaeus vannamei under an artificial seawater condition and a use method of the trace element formula, and relates to the field of industrial recirculating aquaculture. The trace element formula comprises potassium bromide, boric acid, strontium chloride, sodium silicate, zinc sulfate, ferrous sulfate, copper sulfate, manganese chloride, sodium selenite, ammonium molybdate, calcium gluconate and lysine, and the trace elements are added into a common feed to feed penaeus vannamei boone. The defects in the prior art are overcome, the growth efficiency of the penaeus vannamei boone is effectively improved by supplementing related trace elements in the feed, and the economic benefits of culture are increased.

The invention discloses a nutrient solution for nourishing stomach and promoting digestion and a preparation method thereof, and belongs to the technical field of nutrient solutions. Comprising the following steps: mixing hawthorn, mint, erythritol, caulis perllae, rhizoma cyperi, pericarpium citri reticulatae, citron, fructus aurantii, pinellia ternate, white hyacinth bean and semen coicis, adding water, and decocting to obtain a nutritional additive; the preparation method comprises the following steps: mixing glucose, sodium chloride, potassium chloride, vitamin B6, vitamin C, sodium alginate, calcium gluconate, a nutritional additive and deionized water, and uniformly stirring to obtain a material A; mixing soybean protein, lecithin, sodium alginate, high-acyl gellan gum, sucrose fatty acid ester and calcium citrate, and uniformly stirring at 60 DEG C to obtain a material B; and mixing the material A and the material B, and homogenizing to obtain the nutrient solution for nourishing the stomach and promoting digestion. The nutrient solution can be quickly changed into a semi-solid or viscous state when entering the stomach, so that reflux and quick excretion are prevented.

1. Name of the product of this design: Packaging box (Calcium Gluconate Zinc Oral Solution). 2. Purpose of this design product: This design product is used to package oral solution. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention relates to the field of calcium gluconate evaporation crystallization equipment, in particular to a crystallization tank for calcium gluconate crystallization production and a use method thereof, comprising an evaporation crystallization tank, wherein the evaporation crystallization tank comprises a tank body, an inner side of the tank body is provided with a stirring and evenly heating component, one side of the stirring and evenly heating component is installed with an adaptability adjustment component, and the middle part of the tank body is provided with a crystal transfer component; the stirring and evenly heating component is used to stir the solution to be crystallized in the tank body so that the heat is evenly distributed; the adaptability adjustment component is used to adaptively adjust the stirring and evenly heating component according to the evaporation progress; the crystal transfer component is used to transfer and protect precipitated crystals. The present invention can prevent the situation in which crystals continue to accumulate at the bottom of the tank body and become high in the later stage, which is likely to affect the stirring work, and can also effectively reduce the situation in which crystals easily collide with a stirring component as the solution flows, resulting in crystal breakage.

This invention discloses the application of gluconate compounds in the preparation of drugs for the prevention and treatment of ovarian cancer. The gluconate compounds include at least one of sodium gluconate, potassium gluconate, calcium gluconate, and zinc gluconate. The invention also discloses the application of gluconate compounds in the preparation of inhibitors of the interaction between TMEM87A protein and CHP1 protein. This invention is the first to discover and demonstrate that gluconate compounds possess significant anti-ovarian cancer activity, effectively inhibiting the proliferation and metastasis of ovarian cancer cells. It also reveals for the first time a novel anti-cancer mechanism by which sodium gluconate directly binds to TMEM87A protein and disrupts the functional complex formed between TMEM87A and CHP1 protein. This invention overcomes the technical prejudice commonly held by those skilled in the art that gluconates are merely nutritional supplements or chelating agents, providing a novel, safe, and widely available class of candidate drugs for the treatment of ovarian cancer.

The utility model discloses a calcium zinc gluconate solution storage device, which belongs to the technical field of medicine storage and comprises a storage box, a plurality of accommodating grooves are arranged on the storage box, four clamping plates are arranged in the accommodating grooves, and one side of each clamping plate is fixedly connected with two telescopic rods. According to the calcium and zinc gluconate solution storage device, clamping plates, springs, a containing groove and a medicament bottle are arranged, when the medicament bottle needs to be stored, the medicament bottle is firstly placed among the four clamping plates and pressed downwards, due to the fact that the clamping plates are designed to be arc faces, when the medicament bottle is pressed downwards, the medicament bottle can push the clamping plates by a certain distance, and the clamping plates compress the springs; when the medicine bottles are pressed down to the bottoms of the containing grooves, the springs can apply reverse thrust to the clamping plates at the moment, so that the medicine bottles are clamped through the four clamping plates, due to the mobility of the clamping plates, the device can store the medicine bottles of different specifications, and the use range of the device is widened.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

The invention relates to a preparation method for producing calculus bovis by a chemical fermentation technology, which is characterized in that animal bile such as cattle (pigs, sheep and poultry) is used as a raw material, and the calculus bovis is produced by a modern process technology. The composition is prepared from the following components in parts by weight: 8 to 15 parts of taurine, 13 to 26 parts of ox gall powder, 1 to 12 parts of cholic acid, 1 to 17 parts of zinc sulfate, 1 to 15 parts of bilirubin, 20 to 40 parts of calcium gluconate, 20 to 38 parts of deoxycholic acid, 1 to 16 parts of cholesterol, 0.1 to 4.5 parts of fatty acid, 0.05 to 0.95 part of amylase and 0.05 to 2.22 parts of honeysuckle flower extract.