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Calcium gluconate zinc gluconate particulate agent preparation method

A technology of calcium zinc gluconate and calcium gluconate, which is applied in the field of preparation method of calcium zinc gluconate granules, can solve the problems of lowering the quality of medicines, turning yellow or turbid, and low solution stability, and achieves good solubility and improved Taste, the effect of ensuring drug safety

Inactive Publication Date: 2013-12-04
黄华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently on the market, the calcium zinc gluconate oral solution produced by Aonuo Pharmaceutical Co., Ltd. has a formula of calcium gluconate, zinc gluconate, and lysine hydrochloride. The calcium zinc gluconate oral solution is a supersaturated solution. , During storage, white flocculent or granular precipitates will often be precipitated, and there may also be phenomena such as yellowing or turbidity. The stability of the solution is not high, which reduces the quality of the drug

Method used

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  • Calcium gluconate zinc gluconate particulate agent preparation method
  • Calcium gluconate zinc gluconate particulate agent preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A calcium-zinc gluconate granule, its sugar-containing type contains the following ingredients:

[0026] Calcium gluconate 60 parts

[0027] Zinc gluconate 3 parts

[0028] Lysine hydrochloride 10 parts

[0029] 90 parts of sucrose

[0030] Mannitol 28 parts

[0031] 2 parts citric acid

[0032] Sucralose 0.8 parts

[0033] Peach essence 0.2 parts

[0034] Povidone K30 0.3 parts

[0035] The preparation method is as follows: mixing the raw and auxiliary materials evenly, adding purified water to granulate, drying at 60°C, sizing the granules with a 24-mesh sieve, and packing them into composite film bags.

[0036] The calcium zinc gluconate granule preparation of the present invention has a pH value of 4.2.

Embodiment 2

[0038] A calcium-zinc gluconate granule, its sugar-containing type has the following ingredients:

[0039] Calcium gluconate 60 parts

[0040] Zinc gluconate 3 parts

[0041] Lysine hydrochloride 10 parts

[0042] Lactose 40 parts

[0043] Maltose 20 parts

[0044] Mannitol 28 parts

[0045] starch 3 parts

[0046] 4 parts citric acid

[0047] Sodium citrate 2 parts

[0048] Acesulfame K 0.2 parts

[0049] AK sugar 0.2 parts

[0050] Peach essence 0.2 parts

[0051] Sweet orange essence 0.1 parts

[0052] Povidone K30 0.3 parts

[0053] The preparation method is as follows: mixing the raw and auxiliary materials evenly, adding purified water to granulate, drying at 60°C, sizing the granules with a 24-mesh sieve, and packing them into composite film bags.

[0054] The pH value of the calcium zinc gluconate granule preparation of the present invention is 3.9.

Embodiment 3

[0056] A calcium zinc gluconate granule, its sugar-free type has the following ingredients:

[0057] Calcium gluconate 60 parts

[0058] Zinc gluconate 3 parts

[0059] Lysine hydrochloride 10 parts

[0060] Mannitol 70 parts

[0061] Starch 30 parts

[0062] Dextrin 25 parts

[0063] Lactic acid 6 parts

[0064] Stevioside 2 parts

[0065] Peach essence 0.2 parts

[0066] Sweet orange essence 0.1 parts

[0067] Povidone K30 0.3 parts

[0068] The preparation method is as follows: mixing the raw and auxiliary materials evenly, adding purified water to granulate, drying at 60°C, sizing the granules with a 24-mesh sieve, and packing them into composite film bags.

[0069] The calcium zinc gluconate granule preparation of the present invention has a pH value of 4.1.

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Abstract

The invention discloses a calcium gluconate zinc gluconate particulate agent preparation method. The preparation comprises calcium gluconate, zinc gluconate and lysine hydrochloride of effective doses a pH regulator, an excipient, a sweetener, an adhesive, and a fragrance. The particulate agent provided by the invention has stable quality, good taste, and good administration compliance.

Description

technical field [0001] The invention relates to a preparation method of calcium-zinc gluconate granule, which uses calcium gluconate, zinc gluconate and lysine hydrochloride as raw materials to prepare a novel calcium-zinc gluconate preparation, which is used in the field of calcium supplementation for human body and promotion of body development . Background technique [0002] Calcium deficiency can easily cause rickets, osteoporosis and other symptoms. Zinc deficiency can cause growth and mental retardation in children. As a calcium and zinc supplement preparation, this product is mainly used to treat diseases caused by calcium deficiency and zinc, including osteoporosis. Tetany, bone hypoplasia, rickets, supplement for pregnant women, lactating women, menopausal women, growth retardation in children, anorexia, anorexia, recurrent oral ulcers and acne, etc. Lysine hydrochloride has the effect of promoting human growth and development. [0003] Currently on the market, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/315A61P3/02A61P19/10A61P19/08A61P1/02A61P17/10A61P1/14A61K31/28A61K31/198
Inventor 黄华涂涛黄飞
Owner 黄华
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