Nifedipine sustained release tablet and preparation method thereof

A technology of nifedipine and nifedipine is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of poor stability, strong hygroscopicity, and insufficient calcium hydrogen phosphate release. Good and other problems, to achieve the effect of good release, reduce toxic and side effects, and improve bioavailability

Active Publication Date: 2013-10-16
DEZHOU BOCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The Chinese patent with the notification number CN101229140B discloses a nifedipine sustained-release agent and a preparation method thereof. Sodium alginate is used as a sustained-release material. Although the toxic and side effects of the drug can be effectively reduced, the patent nifedipine sustained-release agent has hygroscopicity. Disadvantages of strong and poor stability
And the use of calcium hydrogen phosphate as a filler has the problem of insufficient release

Method used

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  • Nifedipine sustained release tablet and preparation method thereof
  • Nifedipine sustained release tablet and preparation method thereof
  • Nifedipine sustained release tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0071] Example 1 , Nifedipine sustained-release tablets, made of raw and auxiliary materials comprising the following weight ratio:

[0072] Nifedipine 20 parts

[0073] Sodium alginate 30 parts

[0074] Lactose 180 parts

[0075] PVPK30 ethanol solution 36.67 parts

[0076] 1.84 parts of magnesium stearate;

[0077] The preparation process is as follows:

[0078] (1) Ingredients: Take the raw and auxiliary materials of the prescription amount, nifedipine is crushed and passed through a 120-mesh stainless steel sieve; sodium alginate and lactose are passed through a 100-mesh stainless steel sieve;

[0079] (2) Adhesive preparation: put an appropriate amount of 95% ethanol in a clean ingredient barrel, add water to an appropriate amount, then add an appropriate amount of PVPK30 and stir to dissolve it completely, forming a 10% PVP-K30 75% ethanol solution;

[0080] (3) Granulation: Pour part of the raw materials: nifedipine, lactose, sodium alginate into the pot, start t...

Embodiment 2

[0086] Example 2 , Nifedipine sustained-release tablets, made of raw and auxiliary materials comprising the following weight ratio:

[0087] Nifedipine 20 parts

[0088] Sodium alginate 30 parts

[0089] Lactose 180 parts

[0090] Calcium gluconate 5 parts

[0091] PVPK30 ethanol solution 36 parts

[0092] Magnesium stearate 1.84 parts

[0093] The preparation process is the same as in Example 1.

[0094]

Embodiment 3

[0095] Example 3 , Nifedipine sustained-release tablets, made of raw and auxiliary materials comprising the following weight ratio:

[0096] Nifedipine 10 parts

[0097] Sodium alginate 30 parts

[0098] Lactose 150 parts

[0099] PVPK30 ethanol solution 30 parts

[0100] 1 part magnesium stearate

[0101] The preparation process is the same as in Example 1.

[0102]

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Abstract

The invention provides a nifedipine sustained release tablet and a preparation method thereof. The nifedipine sustained release tablet is prepared from nifedipine, sodium alginate, lactose, a PVP-K30 ethanol solution, magnesium stearate and calcium gluconate. The preparation method comprises the following steps: preparing raw materials, preparing the PVP-K30 ethanol solution, thoroughly mixing the raw materials according to the prescribed amount, then adding an appropriate amount of PVP-K30 ethanol solution, and performing mixed granulation; after drying, adding a right amount of magnesium stearate, mixing totally, and then performing tabletting and packaging. The nifedipine sustained release tablet provided by the invention has the advantages of good safety, dissolution curve and stability, low cost and the like.

Description

technical field [0001] The invention relates to a nifedipine sustained-release tablet and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Nifedipine is a kind of dihydropyridine calcium ion channel antagonist, which can selectively inhibit the transmembrane transport of calcium ions into cardiomyocytes and smooth muscle cells, and inhibit the release of calcium ions from the intracellular pool without changing plasma calcium ions concentration. Nifedipine has a strong expansion of coronary arteries and peripheral arteries, and can significantly inhibit vasospasm. It is the drug of choice for variant angina pectoris. It is clinically suitable for the prevention and treatment of coronary heart disease and angina pectoris, especially for variant angina and coronary artery spasm. Cause angina. It is suitable for various types of hypertension, and has a good effect on intractable and severe hypertension. [0003] Due to the short...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61K31/4422A61K47/32A61K47/26A61K47/12A61P31/04
Inventor 刘连鹏张瑞琛赵磊翟志武杨峰
Owner DEZHOU BOCHENG PHARMA
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