1 results about "Nifedipine" patented technology

The present application relates to a preparation process of nifedipine preparation, and belongs to the technical field of drug synthesis. In the present application, PEG4000 and PEG1500 are compounded and used as a solid dispersion carrier, and the main components are distributed in the carrier in a molecular state; sodium carboxymethyl starch and corn starch are selected as filling adjuvants, which can significantly improve the dissolution effect of the raw drug, reduce the adsorption of nifedipine, cooperate with the solid dispersion carrier, further eliminate the adsorption of the raw drug molecules, improve the dissolution degree of the drug, and the dissolution speed is fast. The present application further improves the dissolution degree and dissolution rate of the prepared nifedipine preparation, and more than 90% of the nifedipine preparation can be dissolved in 30 minutes, and finally the dissolution effect close to 100% is realized, and the bioavailability of the drug is significantly improved.