56results about How to "Drug safety" patented technology

The invention discloses a paclitaxel ethosome gel and a preparation method of the paclitaxel ethosome gel. The paclitaxel ethosome gel contains ethosome and gel; the ethosome and the gel are uniformly mixed; the ethosome is particles containing paclitaxel, low-molecular-weight alcohols, phospholipid, cholesterol, a stabilizing agent and an antioxidant; the gel contains a gel matrix, a penetrationaccelerator, a humectant, a preservative, a pH conditioning agent and water; the ethosome and the gel are mixed according to a certain weight proportion, and the ethosome and the gel have specific compositions respectively. According to the paclitaxel ethosome gel provided by the invention, the action of stimulation to the skin can be reduced, and the percutaneous permeation effect is good.

The invention discloses a Tibetan medicine composition with whitening and freckle removing functions and application and a preparation method of the Tibetan medicine composition. Aiming at the defects that in the prior art a whitening and freckle removing product which takes Tibetan medicine materials as raw materials is high in price, the invention provides the Tibetan medicine composition with the whitening and freckle removing functions. The Tibetan medicine composition comprises the following raw material components: 2-4 parts of chishuluodi, 1-3 parts of iris ensata thumb, 1-3 parts of western Sichuan synotis wallichii, 1-3 parts of Chinese parsley fruit and 1-3 parts of swertia multicaulis. The composition is a Tibetan medicine composition which is prepared from components in appreciate ratio. The chemical analysis experiment and the human body testing show that the Tibetan medicine composition has the whitening and freckle removing functions. The Tibetan medicine composition can be used for preparing whitening and freckle removing products, and can be used for preparing whitening and freckle removing medicines and/or healthcare products. The invention further provides a preparation method of the Tibetan medicine composition.

The invention provides a nifedipine double-layer osmotic pump medicinal composition and a preparation technology thereof. The composition comprises a double-layer tablet core and a controlled release coating membrane thereof, wherein the double-layer tablet core is composed of pharmaceutically acceptable excipients and comprises one or more than one of a macromolecular suspending aid substance, an osmotic pressure active substance, a permeation enhancer, a dissolving aid substance, a colorant, a macromolecule swelling substance, a lubricant, a flow aid, an adhesive and a solvent; and the controlled release coating membrane is composed of one or more than one of a membrane forming material, a pore-forming agent and a plasticizer. The nifedipine double-layer osmotic pump medicinal composition prepared by the invention can effectively control a medicament to release in a specific time so that the medicament taking time can be decreased.

The invention provides a compound drop pill of Chinese yew for the auxiliary treatment of lung carcinoma, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, easy administration, low price, and causing no pollution during production. The drop pill is prepared from Chinese yew, red ginseng, licorice root and medicinal carrying agent as the base material.

The present invention provides a mastitis ointment for animals as well as a preparation method and medication thereof. The mastitis ointment is a compound preparation made from ten Chinese medicinal materials with the following weight proportion: 50 to 70g of dandelion, 50 to 70g of tokyo violet herb, 40 to 60g of cortex phellodendri amurensis, 40 to 60g of wild chrysanthemum, 40 to 60g of common selfheal, 40 to 60g of common bletilla, 30 to 50g of earthworm, 30 to 50g of mulberry branch, 30 to 50g of carbonized hair and 30 to 50g of pricklyash berry. The mastitis ointment has the efficacies of clearing toxic heat, promoting blood circulation for removing blood stasis, reducing swelling, discharging pus and removing obstruction in collaterals, which mainly cures earlier acute mastitis, red swelling and thermal pain, carbuncle-abscess and yellowish swelling; moreover, the mastitis ointment is suitable for curing breast diseases of cows, pigs and other livestock such as clinical and recessive mastitis, acromastitis and breast lump, as well as pyogenesis, empyema, breast red swelling and thermal pain, breast skin temperature increase and no latex caused by mechanical and sucking damages. The mastitis ointment based on the production technology of the traditional Chinese black plaster makes certain improvements, thus being more suitable for treatment of cow mastitis.

The invention provides a traditional Chinese medicinal medicament for treating gynaecological metrorrhagia and metrostaxis. The traditional Chinese medicinal medicament for treating gynaecological metrorrhagia and metrostaxis is used for treating metrorrhagia and metrostaxis, caused by yin deficiency and yang pulse, cold-evil in cells and continuous dripping, of women. The traditional Chinese medicinal medicament for treating gynaecological metrorrhagia and metrostaxis is mainly prepared from thirty-one Chinese herbal medicines such as lotus leaf, lotus, fried cypress leaves, uniflower swisscentaury root, szechuan lovage rhizome, soaked dried ginger, cattail pollen, codonopsis pilosula, cinnamon bark core, prepared rehmannia root, Chinese angelica, white paeony root, loranthus parasiticus, horsetail, plant soot, human hair, gardenia, akebiaquinata and prepared cat placenta; on the basis, twenty-five Chinese herbal medicines, namely field moxa, Chinese yam, cimicifugae foetidae, scutellaria baicalensis, prepared fleece flower root, rhizoma anemarrhenae and the like are supplemented for serious and long-treatment patients, and decoction or pills are prepared. The traditional Chinese medicinal medicament for treating gynaecological metrorrhagia and metrostaxis is rigorous and scientific in formula, short in treatment course, quick in effect, gentle in drug properties and safe. Curative ratio for menstrual blood dripping endless type patients is 96%, and effective rate is 99%; the curative ratio for violent menstrual blood type patients is 95%, and effective rate is 97%; the curative ratio for menstrual blood dripping endless and violent menstrual blood type patients is 93%, and effective rate is 95%.

A Chinese medicine for treating hepatitis B is prepared from 9 Chinese-medicinal materials including notoginseng, curcuma root, tribulus fruit, turmeric, etc. Its advantages are high curative effect and no toxic by-effect.

Provided are an Agathobaculum sp. strain having prophylactic or therapeutic effects on degenerative brain diseases, and use thereof. Since the intestinal microorganism Agathobaculum butyriciproducens SR79 strain of the present invention may have effects of inhibiting neuroinflammation and effects of improving movement regulation and cognitive and memory functions in animal models with degenerative brain diseases such as Parkinson's disease and Alzheimer's disease, the strain may be effectively used in foods, medicines, or feeds for preventing or treating brain diseases including Alzheimer's disease, Parkinson's disease, mild cognitive impairment, etc., and therefore, it is very useful in the relevant industries.

The invention relates to a preparation method and application of a nano delivery system for combined administration of adriamycin and methotrexate. The preparation method comprises the following steps: synthesizing 2-(pyridyl dithio)-ethylamine hydrochloride; grafting p-hydroxybenzaldehyde onto carboxyl in hyaluronic acid; then grafting 2-(pyridyl dithio)-ethylamine hydrochloride onto carboxyl ofthe hyaluronic acid; then performing reacting with amino of adriamycin to form an imine bond; dissolving the obtained substance in formamide together with methotrexate; dropwise adding the mixed solution into distilled water to wrap the methotrexate; and finally performing crosslinking under catalysis of dithiothreitol to obtain the nano delivery system for combined administration of adriamycin and methotrexate. The preparation process is relatively simple and is easy to control, combined administration of adriamycin and methotrexate is realized, and the nano delivery system has a pH/GSH double-sensitive characteristic, improves a passive targeting property of drugs, reduces toxic and side effects of drugs on normal tissues and cells, and has a wide application prospect in the field of controlled release of anti-tumor drugs.

The invention discloses an application of a rodgersia sambucifolia extract in preparation of a veterinary drug. The rodgersia sambucifolia extract is used for preparing a drug additive of the veterinary drug for enhancing the immune function of animal bodies, the rodgersia sambucifolia extract is a crude flavonoid extract extracted from a rodgersia sambucifolia plant, the crude flavonoid extract of rodgersia sambucifolia is applied to the drug additive of the veterinary drug, and the drug concentration in the veterinary drug is 1.25-5 mg/mL. The obtained crude flavonoid extract of rodgersia sambucifolia has good biological activity and can promote transformation of lymphocytes in swine lymphocyte transformation experiments, increase the content of WBCs (white blood cells), Gran (neutrophilicgranulocyte) and Lym (lymphocyte) in serum of rats with low immunogenicity and recover the physical condition of rats with immunosuppression. It is indicated that the crude flavonoid extract of rodgersia sambucifolia has the effect of significantly enhancing the immune function of animal bodies and can be used as a raw material of the veterinary drug for enhancing the immune function of animal bodies.

The invention relates to an active attapulgite medicine and a preparation method for the same. The active attapulgite is prepared by activating attapulgite powder with 325-400 meshes for 3-5 hours in a condition of 150-260 DEG C, and 20-100% in percentage by weight within the medicine; and the ratio of the diffraction peak height of christobalite in the active attapulgite to the characteristic peak height of attapulgite is less than 50.0%. The preparation method comprises the following steps of: pre-treating attapulgite clay to obtain an attapulgite crude material liquid, and ultrasonically dispersing to obtain a suspended emulsion; and separating the suspended emulsion to remove materials having a relative density of greater than 2.3 g/cm<3>, centrifugally separating, drying, crushing until the average grain diameter is not greater than 45 microns, and activating the prepared attapulgite powder at a high temperature, thus obtaining the active attapulgite powder. The active attapulgite powder is prepared into a powder without adding pharmaceutic adjuvants, or prepared into a powder, chewable tablets, dispersible tablets, and granules with adding a conventional amount of pharmaceutic adjuvants. The content of christobalite in the active attapulgite powder disclosed by the invention meets the national medicine standards; and christobalite is good in adsorbability and wide in application range.

The invention provides a pharmaceutical composition ethosome, which is prepared from the following components in percentage by weight: 0.1 to 0.2 percent of thymosin beta4, 0.5 to 1 percent of glucocorticoid, 30 to 50 percent of low-molecular-weight alcohol, 3.0 to 12.0 percent of phospholipid, 1.0 to 2.5 percent of cholesterol, 0.51 to 1.3 percent of auxiliaries and the balance of PBS (Phosphate Buffer Solution). The invention also provides a method for preparing the pharmaceutical composition ethosome for treating scars. According to the ethosome, the dosage of hormone can be reduced, side effects can be reduced, the treatment effect is more lasting, scars can be shrunk in the medication process, and after medication is stopped, the scars are not prone to relapse and reach 1 + 1gt; and 2, efficacy. The ethosome disclosed by the invention is strong in transdermal ability, high in encapsulation efficiency, large in drug loading capacity, good in stability and easy to store and use. In addition, the ethosome provided by the invention has toxic and side effects, and is convenient, safe and controllable in administration, good in compliance and higher in bioavailability.

The invention discloses radix tetrastigme spray liquid crystal gel for oral ulcer. The radix tetrastigme spray liquid crystal gel is prepared from the following raw materials in percentage by mass: 1-10% of a radix tetrastigme extract, 20-50% of phospholipid, 20-50% of natural fatty glyceride and/or tocopherol and 5-30% of a biocompatible solvent, compared with the prior art, the tetrastigma hemsleyanum spray liquid crystal gel is moderate in viscosity and good in flowability, can quickly form liquid crystal gel when encountering a small amount of water, can immediately form liquid crystal gel after being sprayed to an ulcer, is short in gel forming time, does not change along with the change of the body temperature of a human body, is stable in structure, and can stably form a layer of protective film on a wound surface; the gel has good mucous membrane adhesion and lubricity, can effectively resist external stimulation, avoid bacterial infection, moisten wound parts and accelerate the healing process, and is convenient and safe in administration.

The invention relates to the technical field of a delivery assisting drug, and particularly relates to a delivery assisting drink and a preparation method and an eating method thereof. The delivery assisting drink comprises the following components in parts by weight: Chinese angelica, rhizoma chuanxiong, tortoise plastron, carbonized hair, radix astragali seu hedysari, radix paeoniae alba, radix salviae miltiorrhizae and prepared liquorice root; and the delivery assisting drink can effectively shorten the parturition time of a pregnant woman, and relieve the parturition pain of the pregnant woman. The preparation method of the delivery assisting drink comprises the following steps of: pretreatment, preparation of concentrated solution, sterilization and packaging. The preparation method is simple in process and low in cost. An eating method of the delivery assisting drink comprises the steps of: taking the packaged liquid medicine, mixing with boiled water, taking 90 to 110ml of liquid medicine each time, and taking for 4 to 6 times. The delivery assisting drink can better play the medicine properties on the basis of not damaging the body.

A medicinal composition for preventing or treating secondary hyperparathyroidism under maintenance dialysis, said medicinal composition comprising 3-{[(2S)-2-amino-2-carboxyethyl]carmaboylamino}-5-chloro-4-methylbenzenesulfonic acid or a pharmaceutically acceptable salt thereof, or a solvate of the same which is to be administered by a predefined route in a predefined dosage. According to the present invention, it is possible to provide a prophylactic or therapeutic agent for secondary hyperparathyroidism under maintenance dialysis, said agent showing reduced side effects or no significant accumulation. This medicinal agent allows easy administration management and has a high safety compared with conventional products.