Propofol-containing fat emulsion

A technology of fat emulsion and propofol, which is applied in the direction of non-active ingredients of oil/fat/wax, anesthetics, anti-inflammatory agents, etc., can solve problems that have not been developed yet, achieve excellent filter permeability, prevent fungal contamination, and reduce The effect of destruction

Inactive Publication Date: 2008-04-02
OTSUKA PHARM FAB INC
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Thus, a propofol-containing fat emulsion formulation that can maintain emulsion stability during its administration and can prevent and / or reduce the occurrence of vascular pain without the introduction of local anesthetics such as lidocaine has not yet been developed.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0079] A fat emulsion formulation (total volume 100 mL) of the present invention comprising the components given in Table 1 described below was prepared as follows. The values ​​in Table 1 represent the weight-to-volume (w / v%) percentage concentration of each component based on the total volume of the fat emulsion formulation obtained.

[0080] The following components were used.

[0081] (1) Propofol (manufactured by ALBEMARLE)

[0082] (2) Soybean oil (refined soybean oil; manufactured by Nisshin Oil Mills, Ltd.)

[0083] (3) Yolk lecithin (purified egg yolk lecithin; produced by Kewpie)

[0084] (4) MCT (C8-10 triglyceride, trade name "Myglyol", produced by SASOL)

[0085] First, propofol given in Table 1, soybean oil and MCT as an oily component were mixed. Add egg yolk lecithin to the resulting mixture. Then, a solution in which glycerol was dissolved in water for injection to obtain a final glycerol concentration of 2.21 w / v% was added thereto, using a Polytron high...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention provides a propofol-containing fat emulsion preparation and a method for preparing the same. The propofol-containing fat emulsion preparation comprises: 0.1-2w / v% propofol, 10-20w / v % oily component, and 2-5w / v% emulsifier, the weight of the oily component is about 5-about 200 times that of propofol, and the weight of the emulsifier is about 0.9-200 times that of propofol about 50 times, and the average particle size of the emulsion particles is 180nm or less. The propofol-containing fat emulsion formulation of the present invention can relieve vascular pain occurring during its administration without introducing a local anesthetic such as lidocaine or the like thereinto.

Description

technical field [0001] The present invention relates to fat emulsion formulations containing propofol for the substantial reduction of vascular pain when such formulations are administered by intravenous injection or infusion. Background technique [0002] Propofol (2,6-diisopropylphenol) is a lipophilic substance that induces a hypnotic state. Since propofol is practically insoluble in water, it is usually formulated as an oil-in-water fat emulsion formulation using an oily component and an emulsifier in such a way that propofol can be administered intravenously or infused Can be administered directly into the bloodstream. Propofol in the form of a fat emulsion formulation is widely used as a general anesthetic, sedative, etc. (eg US Pat. No. 5,714,520). For example, there is known a commercially available propofol-containing fat emulsion preparation (trade name: "1% Diprivan Injection", comprising 1 g of propofol, 10 g of soybean oil, and 1.2 g of egg yolk lecithin, Pro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K9/10A61K47/14A61K47/24A61K47/44A61P23/00A61P25/20
CPCA61K9/0019A61K31/05A61K9/1075A61K9/107A61P23/00A61P25/00A61P25/04A61P25/20A61P29/02A61K9/10A61K47/14
Inventor 武田光市松田宪治寺尾敏光井上忠昭今川昂倍味繁
Owner OTSUKA PHARM FAB INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap